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Difference between revisions of "Hereditary breast cancer"
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Hereditary breast cancer (view source)
Revision as of 16:32, 27 October 2014
, 16:32, 27 October 2014→Syndromes associated with breast cancer
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! Gene | ! Gene | ||
! Syndrome | ! Syndrome | ||
! | ! Cancers | ||
! Notes | ! Notes | ||
|- | |- | ||
| BRCA1 | | BRCA1 | ||
| Familial breast and ovarian cancer<ref name=omim113705>{{OMIM|113705}}</ref> | | Familial breast and ovarian cancer<ref name=omim113705>{{OMIM|113705}}</ref> | ||
| male breast, ovarian, prostate, pancreas, fallopian tube | | breast, male breast, ovarian, prostate, pancreas, fallopian tube | ||
| younger individuals vis-à-vis BRCA2 | | younger individuals vis-à-vis BRCA2 | ||
|- | |- | ||
| BRCA2 | | BRCA2 | ||
| Familial breast and ovarian cancer 2<ref name=omim600185>{{OMIM|600185}}</ref> | | Familial breast and ovarian cancer 2<ref name=omim600185>{{OMIM|600185}}</ref> | ||
| male breast, ovarian, prostate, pancreas, stomach, melanoma, gallbladder, bile duct, pharynx | | breast, male breast, ovarian, prostate, pancreas, stomach, melanoma, gallbladder, bile duct, pharynx | ||
| older individuals vis-à-vis BRCA1 | | older individuals vis-à-vis BRCA1 | ||
|- | |- | ||
| TP53 (p53) | | TP53 (p53) | ||
| [[Li-Fraumeni syndrome]] ([[AKA]] ''SBLA syndrome'') | | [[Li-Fraumeni syndrome]] ([[AKA]] ''SBLA syndrome'') | ||
| [[sarcoma]]s, brain | | [[sarcoma]]s, brain, larynx, lung, leukemia, [[adrenal cortical carcinoma|adrenal]], breast | ||
| often present in childhood | | often present in childhood | ||
|- | |- | ||
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| STK11 | | STK11 | ||
| [[Peutz-Jeghers syndrome]] | | [[Peutz-Jeghers syndrome]] | ||
| breast | | breast, gastrointestinal, [[Sertoli cell tumour]], [[granulosa cell tumour]], [[SCTAT]] | ||
| characteristic GI [[hamartoma]]s, mucocutaneous pigmentation | | characteristic GI [[hamartoma]]s, mucocutaneous pigmentation | ||
|- | |- | ||
| PTEN | | PTEN | ||
| [[Cowden syndrome]] | | [[Cowden syndrome]] | ||
| breast, thyroid (PTC), endometrial, renal, colorectal | | breast, thyroid ([[papillary thyroid carcinoma|PTC]]), endometrial, renal, colorectal | ||
| - | | - | ||
|- | |- | ||