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Difference between revisions of "Hepatic adenoma"
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| Caption = Hepatic adenoma. [[H&E stain]]. | | Caption = Hepatic adenoma. [[H&E stain]]. | ||
| Synonyms = hepatocellular adenoma | | Synonyms = hepatocellular adenoma | ||
| Micro = | | Micro = sheets or cords of cells with mild variation of cell and nuclear size; cords of cells up to 3 cells thick, vascular (large arteries, dilated thin-walled veins), +/-cytoplasmic clearing/pale (due to glycogen); negatives: no bile ducts, no portal tracts, no [[cirrhosis]] | ||
| Subtypes = inflammatory hepatic adenoma ([[AKA]] ''telangiectatic adenoma''), hepatocyte nuclear factor 1 alpha-mutated hepatic adenoma, beta-catenin-mutated hepatic adenoma, unclassified hepatic adenoma | | Subtypes = inflammatory hepatic adenoma ([[AKA]] ''telangiectatic adenoma''), hepatocyte nuclear factor 1 alpha-mutated hepatic adenoma, beta-catenin-mutated hepatic adenoma, unclassified hepatic adenoma | ||
| LMDDx = [[hepatocellular carcinoma]] (well-differentiated), [[focal nodular hyperplasia]] | | LMDDx = [[hepatocellular carcinoma]] (well-differentiated), [[focal nodular hyperplasia]] | ||
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Features: | Features: | ||
*Sheets or cords of cells with mild variation of cell and nuclear size.<ref name=Ref_PBoD923>{{Ref PBoD|923}}</ref> | *Sheets or cords of cells with mild variation of cell and nuclear size.<ref name=Ref_PBoD923>{{Ref PBoD|923}}</ref> | ||
*Cords of cells | *Cords of cells up to 3 cells thick.<ref>STC S.19, 19 Jan 2009.</ref> | ||
*Cells may have cytoplasmic clearing due to glycogen or be pale - '''obvious if seen'''. | *Cells may have cytoplasmic clearing due to glycogen or be pale - '''obvious if seen'''. | ||
*Vascular - large arteries, dilated thin-walled veins. | *Vascular - large arteries, dilated thin-walled veins. | ||
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*No bile ducts. | *No bile ducts. | ||
*No portal tracts. | *No portal tracts. | ||
*No cirrhosis! If cirrhosis is present it isn't a hepatic adenoma - '''important'''. | *No [[cirrhosis]]! If cirrhosis is present it isn't a hepatic adenoma - '''important'''. | ||
DDx: | DDx: | ||
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==IHC== | ==IHC== | ||
*AFP -ve. (???) | *[[AFP]] -ve. (???) | ||
*HNF1alpha +ve/-ve. | *HNF1alpha +ve/-ve. | ||
*Beta-catenin +ve/-ve. | *Beta-catenin +ve/-ve. | ||