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| Synonyms = | | Synonyms = | ||
| Micro = macrophages containing erythrocytes (red blood cells), leukocytes, platelets | | Micro = macrophages containing erythrocytes (red blood cells), leukocytes, platelets | ||
| Subtypes = | | Subtypes = primary, secondary | ||
| LMDDx = overlapping cells, [[emperipolesis]] | | LMDDx = overlapping cells, [[emperipolesis]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = FHL1 mutation or FHL2 mutation in primary form | ||
| IF = | | IF = | ||
| Gross = | | Gross = | ||
| Grossing = | | Grossing = | ||
| Site = | | Site = [[lymph nodes]], [[liver]], [[spleen]], [[bone marrow]], others | ||
| Assdx = | | Assdx = only in ''secondary'' form (EBV infection, malignancy, rheumatologic disease) | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = | | Clinicalhx = +/-consanguinity for ''primary'' form (autosomal recessive) | ||
| Signs = | | Signs = fever, [[splenomegaly]], jaundice | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = rare | | Prevalence = rare | ||
| Bloodwork = | | Bloodwork = +/-EBV serology (secondary form), +/-HIV serology (secondary form) | ||
| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = dependent on underlying cause | | Prognosis = dependent on underlying cause | ||
| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = malignancy | ||
| Tx = | | Tx = dependent on underlying cause | ||
}} | }} | ||
'''Hemophagocytic syndrome''', also known as '''hemophagocytic lymphohistiocytosis''', is a rare condition often associated with viral infections. | '''Hemophagocytic syndrome''', also known as '''hemophagocytic lymphohistiocytosis''', is a rare condition often associated with viral infections. | ||
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DDx: | DDx: | ||
*Overlapping cells (red blood cells overlapping macrophages). | *Overlapping cells (red blood cells overlapping macrophages). | ||
*[[Emperipolesis]]. | *[[Emperipolesis]] in the context of other pathology. | ||
===Images=== | ===Images=== |
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