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Difference between revisions of "Heart transplant pathology"
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Heart transplant pathology (view source)
Revision as of 20:56, 7 January 2011
, 20:56, 7 January 2011mimics
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==Overview - table== | ==Overview - table== | ||
Types of rejection:<ref>{{Ref WMSP|136}}</ref> | ===Types of rejection:<ref name=Ref_WMSP136-7>{{Ref WMSP|136-7}}</ref>=== | ||
{| class="wikitable" | {| class="wikitable" | ||
| Type (grade) | | Type (grade) | ||
| Line 17: | Line 17: | ||
| edema, dilated small vessels | | edema, dilated small vessels | ||
| scant inflammation | | scant inflammation | ||
| [http://www.pathconsultddx.com/pathCon/largeImage?pii=S1559-8675%2806%2970592-7&figureId=fig4] | | [http://www.pathconsultddx.com/pathCon/largeImage?pii=S1559-8675%2806%2970592-7&figureId=fig4 acute] | ||
|- | |- | ||
| cellular (0R) | | cellular (0R) | ||
| Line 27: | Line 27: | ||
| infiltrate, myocyte damage | | infiltrate, myocyte damage | ||
| scant interstitial infiltrate (lymphoplasmic), scant damage | | scant interstitial infiltrate (lymphoplasmic), scant damage | ||
| [http://www.pathconsultddx.com/pathCon/largeImage?pii=S1559-8675%2806%2970592-7&figureId=fig1 mild] | | [http://www.pathconsultddx.com/pathCon/largeImage?pii=S1559-8675%2806%2970592-7&figureId=fig1 mild cellular] | ||
|- | |- | ||
| cellular (2R) | | cellular (2R) | ||
| space-occupying lesion | | space-occupying lesion | ||
| diffuse interstitial infiltrate displaces parenchyma (lymphoplasmic), obvious damage | | diffuse interstitial infiltrate displaces parenchyma (lymphoplasmic), obvious damage | ||
| [http://www.pathconsultddx.com/pathCon/largeImage?pii=S1559-8675%2806%2970592-7&figureId=fig2 mod.], [http://www.pathconsultddx.com/pathCon/largeImage?pii=S1559-8675%2806%2970592-7&figureId=fig3 mod. resolving] | | [http://www.pathconsultddx.com/pathCon/largeImage?pii=S1559-8675%2806%2970592-7&figureId=fig2 mod. cellular], [http://www.pathconsultddx.com/pathCon/largeImage?pii=S1559-8675%2806%2970592-7&figureId=fig3 mod. cellular resolving] | ||
|- | |- | ||
| cellular (3R) | | cellular (3R) | ||
| Line 42: | Line 42: | ||
| concentric intimal thicking | | concentric intimal thicking | ||
| internal elastic lamina preserved (unlike atherosclerosis) | | internal elastic lamina preserved (unlike atherosclerosis) | ||
| [http://newsroom.ucla.edu/portal/ucla/srp-view.aspx?id=118724], [http://www.pathconsultddx.com/pathCon/largeImage?pii=S1559-8675%2806%2970592-7&figureId=fig5] | | [http://newsroom.ucla.edu/portal/ucla/srp-view.aspx?id=118724 chronic], [http://www.pathconsultddx.com/pathCon/largeImage?pii=S1559-8675%2806%2970592-7&figureId=fig5 chronic] | ||
|} | |||
===Pitfalls:<ref name=Ref_WMSP136-7>{{Ref WMSP|136-7}}</ref>=== | |||
{| class="wikitable" | |||
| Name | |||
| Description | |||
| Details | |||
| Image | |||
|- | |||
| Quilty A | |||
| endocardial/subendocardial B-lymphocytes (in clusters) | |||
| benign behaviour clinically | |||
| [http://medeponyms.com/entry/7/ Quilty effect], [http://www.e-heart.org/Pages/08_Heart_Transplant/08_Heart_Transplant_ELI%20_001.htm Quilty effect] | |||
|- | |||
| Quilty B | |||
| B-lymphocytes (in clusters) | |||
| +/-myocyte damage; benign behaviour clinically | |||
| [http://medeponyms.com/entry/7/ Quilty effect], [http://www.e-heart.org/Pages/08_Heart_Transplant/08_Heart_Transplant_ELI%20_001.htm Quilty effect] | |||
|- | |||
| Old biopsy site | |||
| hemosiderin-laden macrophages | |||
| fibrosis/myocyte replacement | |||
| [http://www.pathconsultddx.com/pathCon/largeImage?pii=S1559-8675%2806%2970592-7&figureId=fig6 old Bx site] | |||
|} | |} | ||
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==Cellular rejection== | ==Cellular rejection== | ||
Grading scheme 2004/1990:<ref>{{Ref WMSP|136}}</ref> | Grading scheme 2004/1990:<ref name=Ref_WMSP136>{{Ref WMSP|136}}</ref> | ||
{| class="wikitable" | {| class="wikitable" | ||
| Grade 2004 | | Grade 2004 | ||
| Line 141: | Line 164: | ||
==References== | ==References== | ||
{{Reflist| | {{Reflist|2}} | ||
==External links== | ==External links== | ||