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Difference between revisions of "Haematopathology"
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**B lymphocytes. | **B lymphocytes. | ||
**Plasma cells. | **Plasma cells. | ||
=Haematologic neoplasia= | |||
Historically, haematologic neoplasias were split into leukemia (disease of the bone marrow & blood) and lymphoma (disease in discrete masses -- usually lymph nodes). In the modern day, this distinction has blurred. | |||
==Myelodysplastic syndrome== | |||
{{Main|Myelodysplastic syndrome}} | |||
At first approximation, these can be thought of as "pre-leukemia/lymphoma". | |||
==Leukemia== | |||
{{Main|Leukemia}} | |||
These predominantly have blood/bone marrow involvement. | |||
==Lymphoma== | |||
{{main|Lymphoma}} | |||
These form masses. They typically arise from lymph nodes or aggregates of lymphocytes. | |||
==Plasma cell lesions== | |||
{{Main|Plasma cell neoplasms}} | |||
==Myeloproliferative neoplasms== | |||
{{main|Myeloproliferative neoplasms}} | |||
This subset of haematopathology includes, among others, polycythemia vera. Historically, these were not classified as neoplasias. | |||
=Specific diagnoses= | =Specific diagnoses= | ||
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Notes: | Notes: | ||
*Microvascular occlusion is also seen in [[thrombotic microangiopathies]]. | *Microvascular occlusion is also seen in [[thrombotic microangiopathies]]. | ||
=Cytometry - population cell marker quantification= | =Cytometry - population cell marker quantification= | ||
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===Common markers=== | ===Common markers=== | ||
*CD3, CD4, CD8, CD5, CD7. | *CD3, CD4, CD8, [[CD5]], CD7. | ||
*CD19, CD20, FMC7. | *CD19, [[CD20]], FMC7. | ||
*Kappa, lambda. | *Kappa, lambda. | ||
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===Abnormal=== | ===Abnormal=== | ||
See ''[[cytometry]]''. | See ''[[cytometry]]''. | ||
=Abnormal sign out= | |||
<pre> | |||
Lymph Node, Right Posterior Triangle of Neck, Excision: | |||
- Lymphoid tissue with abnormal architecture, predominantly small cells. | |||
- Case will be sent to hematopathology for opinion. | |||
</pre> | |||
=See also= | =See also= | ||