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Hürthle cell neoplasm (view source)
Revision as of 14:04, 17 February 2016
, 14:04, 17 February 2016→Adenoma versus carcinoma
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'''Hürthle cell neoplasm''' is a rare tumour of the [[thyroid gland]] that can have a benign or malignant behaviour. | [[Image:Hurthle cell carcinoma -- very high mag.jpg|thumb|right|300px|Micrograph showing a (metastatic) Hürthle cell carcinoma. [[H&E stain]].]] | ||
'''Hürthle cell neoplasm''' is a rare tumour of the [[thyroid gland]] that can have a benign or malignant behaviour. They are generally considered a subset of [[follicular neoplasm]],<ref name=pmid26530486>{{Cite journal | last1 = Wei | first1 = S. | last2 = LiVolsi | first2 = VA. | last3 = Montone | first3 = KT. | last4 = Morrissette | first4 = JJ. | last5 = Baloch | first5 = ZW. | title = PTEN and TP53 Mutations in Oncocytic Follicular Carcinoma. | journal = Endocr Pathol | volume = 26 | issue = 4 | pages = 365-9 | month = Dec | year = 2015 | doi = 10.1007/s12022-015-9403-6 | PMID = 26530486 }}</ref><ref name=pmid24753500>{{Cite journal | last1 = Ustun | first1 = B. | last2 = Chhieng | first2 = D. | last3 = Van Dyke | first3 = A. | last4 = Carling | first4 = T. | last5 = Holt | first5 = E. | last6 = Udelsman | first6 = R. | last7 = Adeniran | first7 = AJ. | title = Risk stratification in follicular neoplasm: a cytological assessment using the modified Bethesda classification. | journal = Cancer Cytopathol | volume = 122 | issue = 7 | pages = 536-45 | month = Jul | year = 2014 | doi = 10.1002/cncy.21425 | PMID = 24753500 }}</ref> which includes [[follicular thyroid carcinoma]] and [[follicular thyroid adenoma]]. | |||
It may be referred to as ''[[oncocytic neoplasm]]''. | It may be referred to as ''[[oncocytic neoplasm]]''. | ||
'''Hürthle cell carcinoma''' and '''Hürthle cell adenoma''' redirect to here. | '''Hürthle cell carcinoma''' and '''Hürthle cell adenoma''' redirect to here. | ||
==General== | ==General== | ||
*Incidence: uncommon. | *Incidence: uncommon. | ||
| Line 17: | Line 19: | ||
Suggestive for carcinoma:<ref name=pmid9697901/> | Suggestive for carcinoma:<ref name=pmid9697901/> | ||
*Male. | *Male. | ||
*>4 cm | *>4 cm. | ||
**Adenomas usu. <3 cm. | **Adenomas usu. <3 cm. | ||
Definite for carcinoma:<ref name=pmid9697901/> | Definite for carcinoma:<ref name=pmid9697901/> | ||
*Lymphovascular invasion. | *[[Lymphovascular invasion]]. | ||
*Capsular invasion. | *Capsular invasion. | ||
===Gross | ====Risk of malignancy by tumour size==== | ||
Risk of malignancy by size - based on a series of 57 cases:<ref name=pmid9563543>{{Cite journal | last1 = Chen | first1 = H. | last2 = Nicol | first2 = TL. | last3 = Zeiger | first3 = MA. | last4 = Dooley | first4 = WC. | last5 = Ladenson | first5 = PW. | last6 = Cooper | first6 = DS. | last7 = Ringel | first7 = M. | last8 = Parkerson | first8 = S. | last9 = Allo | first9 = M. | title = Hürthle cell neoplasms of the thyroid: are there factors predictive of malignancy? | journal = Ann Surg | volume = 227 | issue = 4 | pages = 542-6 | month = Apr | year = 1998 | doi = | PMID = 9563543 }}</ref> | |||
{| class="wikitable sortable" | |||
!Size | |||
!Percentage<br>malignant | |||
|- | |||
| <=1 cm | |||
| 17% | |||
|- | |||
|- | |||
| 1-4 cm | |||
| 23% | |||
|- | |||
| >4 cm | |||
| 65% | |||
|} | |||
==Gross== | |||
*Yellow. | *Yellow. | ||
*Encapsulated. | *Encapsulated. | ||
| Line 42: | Line 61: | ||
*Medullary thyroid carcinoma oncocytic variant. | *Medullary thyroid carcinoma oncocytic variant. | ||
*Others. | *Others. | ||
===Images=== | |||
<gallery> | |||
Image: Hurthle cell carcinoma -- intermed mag.jpg | HCC - intermed. mag. (WC) | |||
Image: Hurthle cell carcinoma -- high mag.jpg | HCC - high mag. (WC) | |||
Image: Hurthle cell carcinoma -- very high mag.jpg | HCC - very high mag. (WC) | |||
Image: Hurthle cell carcinoma - atl -- very high mag.jpg | HCC - very high mag. (WC) | |||
</gallery> | |||
==IHC== | ==IHC== | ||
| Line 55: | Line 82: | ||
*[[Thyroid gland]]. | *[[Thyroid gland]]. | ||
*[[Oncocytoma]]. | *[[Oncocytoma]]. | ||
*[[Follicular neoplasm]]. | |||
==References== | ==References== | ||