Difference between revisions of "Graves' disease"
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'''Graves' disease''', also '''Graves disease''', is an | '''Graves' disease''', also '''Graves disease''', is an autoimmune disease that leads to hyperthyroidism. | ||
It is often misspelled "Grave's disease". | |||
==General== | ==General== | ||
*Autoimmune disease leading to hyperthyroidism. | *Autoimmune disease leading to hyperthyroidism. | ||
*Eye problems not resolved with thyroid removal.{{fact}} | *Eye problems not resolved with thyroid removal.{{fact}} | ||
| Line 28: | Line 29: | ||
Notes: | Notes: | ||
*Usually has an unimpressive appearance... as it is treated, i.e. history is important. | *Usually has an unimpressive appearance... as it is treated, i.e. history is important. | ||
*Nuclear clearing and papillae are usu. diffuse in Graves disease - unlike in papillary thyroid carcinoma. | *Nuclear clearing and papillae are usu. diffuse in Graves' disease - unlike in papillary thyroid carcinoma. | ||
===Images=== | ===Images=== | ||
www: | www: | ||
*[http://library.med.utah.edu/WebPath/jpeg4/ENDO022.jpg Graves disease (med.utah.edu)].<ref>URL: [http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/enfrm.html http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/enfrm.html]. Accessed on: 4 December 2011.</ref> | *[http://library.med.utah.edu/WebPath/jpeg4/ENDO022.jpg Graves' disease (med.utah.edu)].<ref>URL: [http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/enfrm.html http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/enfrm.html]. Accessed on: 4 December 2011.</ref> | ||
*[http://medcell.med.yale.edu/histology/endocrine_systems_lab/graves_disease.php Graves disease & normal thyroid (yale.edu)]. | *[http://medcell.med.yale.edu/histology/endocrine_systems_lab/graves_disease.php Graves' disease & normal thyroid (yale.edu)]. | ||
==See also== | ==See also== | ||
Revision as of 20:55, 24 October 2015
Graves' disease, also Graves disease, is an autoimmune disease that leads to hyperthyroidism.
It is often misspelled "Grave's disease".
General
- Autoimmune disease leading to hyperthyroidism.
- Eye problems not resolved with thyroid removal.[citation needed]
- Higher risk of papillary thyroid carcinoma.
Clinical:
- TSH-receptor antibody +ve.[1]
Gross
Features:[2]
- Enlarged 50-150 g.
- "Beefy-red" appearance, looks like raw beef.
Microscopic
Features:
- Classic:
- Hypercellular
- Patchy lymphocytes.
- Little colloid.
- Scalloping of colloid; colloid has undulating border.
- Non-specific finding.
- +/-Nuclear clearing.
- +/-Papillae (may mimic papillary thyroid carcinoma in this respect).
Notes:
- Usually has an unimpressive appearance... as it is treated, i.e. history is important.
- Nuclear clearing and papillae are usu. diffuse in Graves' disease - unlike in papillary thyroid carcinoma.
Images
www:
See also
References
- ↑ Massart, C.; Gibassier, J.; d'Herbomez, M. (Sep 2009). "Clinical value of M22-based assays for TSH-receptor antibody (TRAb) in the follow-up of antithyroid drug treated Graves' disease: comparison with the second generation human TRAb assay.". Clin Chim Acta 407 (1-2): 62-6. doi:10.1016/j.cca.2009.06.033. PMID 19576193.
- ↑ Thompson, Lester D. R. (2006). Endocrine Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 30. ISBN 978-0443066856.
- ↑ URL: http://library.med.utah.edu/WebPath/EXAM/IMGQUIZ/enfrm.html. Accessed on: 4 December 2011.