Difference between revisions of "Granulocytic sarcoma"
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'''Granulocytic sarcoma''' is an uncommon [[malignant]] [[soft tissue lesion]] that is really represents a hematologic malignancy; it is a soft tissue manifestation of [[acute myeloid leukemia]]. It is ''not'' a [[sarcoma]]. | |||
Numerous other terms refer to this including '''extramedullary leukemia''',<ref name=pmid21795742>{{Cite journal | last1 = Bakst | first1 = RL. | last2 = Tallman | first2 = MS. | last3 = Douer | first3 = D. | last4 = Yahalom | first4 = J. | title = How I treat extramedullary acute myeloid leukemia. | journal = Blood | volume = 118 | issue = 14 | pages = 3785-93 | month = Oct | year = 2011 | doi = 10.1182/blood-2011-04-347229 | PMID = 21795742 }}</ref> '''myeloid sarcoma''' and '''chloroma'''. | |||
Less common terms include:<ref name=pmid21556238>{{Cite journal | last1 = Eom | first1 = KS. | last2 = Kim | first2 = TY. | title = Intraparenchymal myeloid sarcoma and subsequent spinal myeloid sarcoma for acute myeloblastic leukemia. | journal = J Korean Neurosurg Soc | volume = 49 | issue = 3 | pages = 171-4 | month = Mar | year = 2011 | doi = 10.3340/jkns.2011.49.3.171 | PMID = 21556238 | PMC = 3085814 | url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085814/ }}</ref> '''myeloblastoma''', '''chloromyeloma''', '''chloromyelosarcoma''', '''granulocytic leukosarcoma''', and '''myelosarcoma'''. | |||
==General== | |||
*Soft tissue manifestation of [[acute myeloid leukemia]].<ref name=pmid21556238/> | |||
==Microscopic== | |||
Features: | |||
*Cluster of atypical small blue cells in [[soft tissue lesions|soft tissue]]. | |||
Note: | |||
*May mimic [[small cell carcinoma]], large cell lymphomas ([[DLBCL]], [[ALCL]]), [[small round cell tumour]]s. | |||
===Images=== | |||
<gallery> | |||
Image:Chloroma - intermed mag.jpg | Chloroma - intermed. mag. (WC) | |||
Image:Chloroma_-_high_mag.jpg | Chloroma - high mag. (WC) | |||
Image:Chloroma_-_very_high_mag.jpg | Chloroma - very high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://path.upmc.edu/cases/case306/micro.html Granulocytic sarcoma - several crappy images (upmc.edu)]. | |||
*[http://path.upmc.edu/cases/case379.html Myeloid sarcoma - several images (upmc.edu)]. | |||
==Sign out== | |||
*It is prudent to mention ''acute myeloid leukemia'' somewhere in the report to ensure the appropriate referral is made. | |||
==See also== | |||
*[[Soft tissue lesions]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Soft tissue lesions]] | |||
Revision as of 21:01, 5 April 2014
Granulocytic sarcoma is an uncommon malignant soft tissue lesion that is really represents a hematologic malignancy; it is a soft tissue manifestation of acute myeloid leukemia. It is not a sarcoma.
Numerous other terms refer to this including extramedullary leukemia,[1] myeloid sarcoma and chloroma.
Less common terms include:[2] myeloblastoma, chloromyeloma, chloromyelosarcoma, granulocytic leukosarcoma, and myelosarcoma.
General
- Soft tissue manifestation of acute myeloid leukemia.[2]
Microscopic
Features:
- Cluster of atypical small blue cells in soft tissue.
Note:
- May mimic small cell carcinoma, large cell lymphomas (DLBCL, ALCL), small round cell tumours.
Images
Chloroma - intermed. mag. (WC)
Chloroma - high mag. (WC)
Chloroma - very high mag. (WC)
www:
- Granulocytic sarcoma - several crappy images (upmc.edu).
- Myeloid sarcoma - several images (upmc.edu).
Sign out
- It is prudent to mention acute myeloid leukemia somewhere in the report to ensure the appropriate referral is made.
See also
References
- ↑ Bakst, RL.; Tallman, MS.; Douer, D.; Yahalom, J. (Oct 2011). "How I treat extramedullary acute myeloid leukemia.". Blood 118 (14): 3785-93. doi:10.1182/blood-2011-04-347229. PMID 21795742.
- ↑ 2.0 2.1 Eom, KS.; Kim, TY. (Mar 2011). "Intraparenchymal myeloid sarcoma and subsequent spinal myeloid sarcoma for acute myeloblastic leukemia.". J Korean Neurosurg Soc 49 (3): 171-4. doi:10.3340/jkns.2011.49.3.171. PMC 3085814. PMID 21556238. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085814/.