Granular cell tumour
The granular cell tumour is a rare beast.
General
- Rare.
- Usually benign.
- May mimic (well-differentiated) squamous cell carcinoma - histopathologically.
- There is a well-described phenomenon called pseudoepitheliomatous hyperplasia.[1]
Aside:
- Pseudoepitheliomatous hyperplasia is seen in:
- Fungal infections.
- Inflammatory papillary hyperplasia.
- Granular cell tumour.
- Adjacent to an ulcer.
Gross
- Yellow nodule.
Note:
- DDx of yellow nodule: granular cell tumour, lipoma, xanthoma.
Microscopic
Features:
- Cells with abundant eosinophilic granular cytoplasm - key feature.
- Granules:
- Size: 1-3 micrometers.
- Poorly demarcated.
- Granules:
- Nested architecture.
- +/-Pseudoepitheliomatous hyperplasia.
- May mimic SCC.
DDx:
Special stains
- PAS +ve.
IHC
Features:[2]
- S100 +ve.
- CD68 +ve (cytoplasmic).
- Vimentin +ve (membranous).
- Calretinin +ve (90-95%).[3]
Images:
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See also
References
- ↑ Abu-Eid R, Landini G (March 2006). "Morphometrical differences between pseudoepitheliomatous hyperplasia in granular cell tumours and squamous cell carcinomas". Histopathology 48 (4): 407–16. doi:10.1111/j.1365-2559.2006.02350.x. PMID 16487362.
- ↑ Rekhi, B.; Jambhekar, NA. (Jun 2010). "Morphologic spectrum, immunohistochemical analysis, and clinical features of a series of granular cell tumors of soft tissues: a study from a tertiary referral cancer center.". Ann Diagn Pathol 14 (3): 162-7. doi:10.1016/j.anndiagpath.2010.01.005. PMID 20471560.
- ↑ Fine, SW.; Li, M. (Feb 2003). "Expression of calretinin and the alpha-subunit of inhibin in granular cell tumors.". Am J Clin Pathol 119 (2): 259-64. doi:10.1309/GRH4-JWX6-J9J7-QQTA. PMID 12579997.