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Difference between revisions of "Granular cell tumour"
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| Caption = Granular cell tumour. [[H&E stain]]. | | Caption = Granular cell tumour. [[H&E stain]]. | ||
| Micro = cells with abundant eosinophilic granular cytoplasm (granules ~ 1-3 micrometers, poorly demarcated on LM), +/-[[pseudoepitheliomatous hyperplasia]] | | Micro = cells (usually epithelioid) with (usually abundant) eosinophilic granular cytoplasm (granules ~ 1-3 micrometers, poorly demarcated on LM), +/-[[pseudoepitheliomatous hyperplasia]] | ||
| Subtypes = benign (common), malignant (uncommon) | | Subtypes = benign (common), malignant (uncommon) | ||
| LMDDx = [[squamous cell carcinoma]], [[oncocytoma]], adjacent ulcer, [[xanthoma]], [[melanocytic nevus]] with neurotization | | LMDDx = [[squamous cell carcinoma]], [[oncocytoma]], adjacent ulcer, [[xanthoma]], [[melanocytic nevus]] with neurotization | ||
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*Granular cell tumour. | *Granular cell tumour. | ||
*[[Lipoma]]. | *[[Lipoma]]. | ||
*Xanthoma. | *[[Xanthoma]]. | ||
==Microscopic== | ==Microscopic== | ||
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***Size: 1-3 micrometers. | ***Size: 1-3 micrometers. | ||
***Poorly demarcated (on light microscopy). | ***Poorly demarcated (on light microscopy). | ||
*Nested architecture. | **Poorly defined cellular borders. | ||
*Nested architecture or syncytial growth pattern. | |||
*+/-Pustulo-ovoid bodies (focal eosinophilic granules surrounded by a clear halo).<ref name=pmid22760808>{{Cite journal | last1 = Fernandes | first1 = BF. | last2 = Belfort Neto | first2 = R. | last3 = Odashiro | first3 = AN. | last4 = Pereira | first4 = PR. | last5 = Burnier | first5 = MN. | title = Clinical and histopathological features of orbital granular cell tumor: case report. | journal = Arq Bras Oftalmol | volume = 75 | issue = 2 | pages = 137-9 | month = | year = | doi = | PMID = 22760808 }}</ref> | |||
*+/-Pseudoepitheliomatous hyperplasia. | *+/-Pseudoepitheliomatous hyperplasia. | ||
**May mimic [[SCC]]. | **May mimic [[SCC]]. | ||
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==Special stains== | ==Special stains== | ||
*PAS +ve. | *PAS +ve. | ||
*PASD +ve (pustulo-ovoid bodies). | |||
==IHC== | ==IHC== | ||