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Difference between revisions of "Goblet cell adenocarcinoma"
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| Caption = Goblet cell adenocarcinoma. [[H&E stain]]. | | Caption = Goblet cell adenocarcinoma. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = goblet cell carcinoid (obsolete term), crypt cell carcinoma | ||
| Micro = small clusters of cells with stippled chromatin and a goblet cell-like appearance | | Micro = small clusters of cells with stippled chromatin and a goblet cell-like appearance | ||
| Subtypes = | | Subtypes = | ||
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'''Goblet cell adenocarcinoma''' is a rare malignant tumour that is typically seen in the [[vermiform appendix]].<ref>{{cite journal |authors=Kiyosawa N, Koyama M, Miyagawa Y, Kitazawa M, Tokumaru S, Soejima Y |title=Goblet cell adenocarcinoma of the appendix: A case report of three cases |journal=Int J Surg Case Rep |volume=106 |issue= |pages=108229 |date=April 2023 |pmid=37084554 |doi=10.1016/j.ijscr.2023.108229 |url=}}</ref> | '''Goblet cell adenocarcinoma''' is a rare malignant tumour that is typically seen in the [[vermiform appendix]].<ref>{{cite journal |authors=Kiyosawa N, Koyama M, Miyagawa Y, Kitazawa M, Tokumaru S, Soejima Y |title=Goblet cell adenocarcinoma of the appendix: A case report of three cases |journal=Int J Surg Case Rep |volume=106 |issue= |pages=108229 |date=April 2023 |pmid=37084554 |doi=10.1016/j.ijscr.2023.108229 |url=}}</ref> | ||
It has gone by a number of different names in the past: '''crypt cell carcinoma''', '''goblet cell carcinoid'''<ref name=pmid18042066>{{cite journal |author=van Eeden S, Offerhaus GJ, Hart AA, ''et al.'' |title=Goblet cell carcinoid of the appendix: a specific type of carcinoma |journal=Histopathology |volume=51 |issue=6 |pages=763–73 |year=2007 |month=December |pmid=18042066 |doi=10.1111/j.1365-2559.2007.02883.x |url=}}</ref><ref name=pmid15967038>{{Cite journal | last1 = Pahlavan | first1 = PS. | last2 = Kanthan | first2 = R. | title = Goblet cell carcinoid of the appendix. | journal = World J Surg Oncol | volume = 3 | issue = | pages = 36 | month = Jun | year = 2005 | doi = 10.1186/1477-7819-3-36 | PMID = 15967038 }}</ref> | It has gone by a number of different names in the past: '''crypt cell carcinoma''',<ref>{{cite journal |authors=Limaiem F, Omrani S, Hajri M |title=Goblet cell adenocarcinoma of the ascending colon: An underrecognized diagnostic pitfall |journal=Clin Case Rep |volume=11 |issue=1 |pages=e6822 |date=January 2023 |pmid=36654693 |pmc=9834544 |doi=10.1002/ccr3.6822 |url=}}</ref> '''goblet cell carcinoid'''<ref>{{cite journal |authors=Sigley K, Franklin M, Welch S |title=Appendiceal Goblet Cell Adenocarcinoma Case Report and Review of the Literature |journal=Cureus |volume=13 |issue=2 |pages=e13511 |date=February 2021 |pmid=33786220 |pmc=7992912 |doi=10.7759/cureus.13511 |url=}}</ref><ref name=pmid18042066>{{cite journal |author=van Eeden S, Offerhaus GJ, Hart AA, ''et al.'' |title=Goblet cell carcinoid of the appendix: a specific type of carcinoma |journal=Histopathology |volume=51 |issue=6 |pages=763–73 |year=2007 |month=December |pmid=18042066 |doi=10.1111/j.1365-2559.2007.02883.x |url=}}</ref><ref name=pmid15967038>{{Cite journal | last1 = Pahlavan | first1 = PS. | last2 = Kanthan | first2 = R. | title = Goblet cell carcinoid of the appendix. | journal = World J Surg Oncol | volume = 3 | issue = | pages = 36 | month = Jun | year = 2005 | doi = 10.1186/1477-7819-3-36 | PMID = 15967038 }}</ref> | ||
and '''[[neuroendocrine tumour]] with goblet cell differentiation'''. | and '''[[neuroendocrine tumour]] with goblet cell differentiation'''. | ||
==General== | ==General== | ||
*Rare appendiceal tumour that typically has an aggressive course vis- | *Rare appendiceal tumour that typically has an aggressive course vis-à-vis [[appendiceal carcinoid]]s.<ref name=pmid18042066>{{cite journal |author=van Eeden S, Offerhaus GJ, Hart AA, ''et al.'' |title=Goblet cell carcinoid of the appendix: a specific type of carcinoma |journal=Histopathology |volume=51 |issue=6 |pages=763–73 |year=2007 |month=December |pmid=18042066 |doi=10.1111/j.1365-2559.2007.02883.x |url=}}</ref> | ||
*Mixed (biphasic) tumour with endocrine and exocrine features. | *Mixed (biphasic) tumour with endocrine and exocrine features. | ||
*Usually presents as [[acute appendicitis]].<ref name=pmid15967038/> | *Usually presents as [[acute appendicitis]].<ref name=pmid15967038/> | ||