Difference between revisions of "Goblet cell adenocarcinoma"

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Goblet cell adenocarcinoma (view source)

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| Image      = Goblet_cell_carcinoid_-2-_very_high_mag.jpg
| Image      = Goblet_cell_carcinoid_-2-_very_high_mag.jpg
| Width      =
| Width      =
| Caption    = Crypt cell carcinoma. [[H&E stain]].
| Caption    = Goblet cell adenocarcinoma. [[H&E stain]].
| Synonyms  = goblet cell carcinoid (obsolete term), crypt cell carcinoma
| Micro      = small clusters of cells with stippled chromatin and a goblet cell-like appearance
| Micro      = small clusters of cells with stippled chromatin and a goblet cell-like appearance
| Subtypes  =
| Subtypes  =
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| ClinDDx    = [[acute appendicitis]], other appendiceal tumours, other abdominal pathology
| ClinDDx    = [[acute appendicitis]], other appendiceal tumours, other abdominal pathology
}}
}}
'''Crypt cell carcinoma''', also known as '''goblet cell carcinoid'''<ref name=pmid18042066>{{cite journal |author=van Eeden S, Offerhaus GJ, Hart AA, ''et al.'' |title=Goblet cell carcinoid of the appendix: a specific type of carcinoma |journal=Histopathology |volume=51 |issue=6 |pages=763–73 |year=2007 |month=December |pmid=18042066 |doi=10.1111/j.1365-2559.2007.02883.x |url=}}</ref><ref name=pmid15967038>{{Cite journal  | last1 = Pahlavan | first1 = PS. | last2 = Kanthan | first2 = R. | title = Goblet cell carcinoid of the appendix. | journal = World J Surg Oncol | volume = 3 | issue =  | pages = 36 | month = Jun | year = 2005 | doi = 10.1186/1477-7819-3-36 | PMID = 15967038 }}</ref>  
'''Goblet cell adenocarcinoma''' is a rare malignant tumour that is typically seen in the [[vermiform appendix]].<ref>{{cite journal |authors=Kiyosawa N, Koyama M, Miyagawa Y, Kitazawa M, Tokumaru S, Soejima Y |title=Goblet cell adenocarcinoma of the appendix: A case report of three cases |journal=Int J Surg Case Rep |volume=106 |issue= |pages=108229 |date=April 2023 |pmid=37084554 |doi=10.1016/j.ijscr.2023.108229 |url=}}</ref>
and '''[[neuroendocrine tumour]] with goblet cell differentiation''', is a rare malignant tumour that is typically seen in the [[vermiform appendix]].
 
It has gone by a number of different names in the past: '''crypt cell carcinoma''',<ref>{{cite journal |authors=Limaiem F, Omrani S, Hajri M |title=Goblet cell adenocarcinoma of the ascending colon: An underrecognized diagnostic pitfall |journal=Clin Case Rep |volume=11 |issue=1 |pages=e6822 |date=January 2023 |pmid=36654693 |pmc=9834544 |doi=10.1002/ccr3.6822 |url=}}</ref> '''goblet cell carcinoid'''<ref>{{cite journal |authors=Sigley K, Franklin M, Welch S |title=Appendiceal Goblet Cell Adenocarcinoma Case Report and Review of the Literature |journal=Cureus |volume=13 |issue=2 |pages=e13511 |date=February 2021 |pmid=33786220 |pmc=7992912 |doi=10.7759/cureus.13511 |url=}}</ref><ref name=pmid18042066>{{cite journal |author=van Eeden S, Offerhaus GJ, Hart AA, ''et al.'' |title=Goblet cell carcinoid of the appendix: a specific type of carcinoma |journal=Histopathology |volume=51 |issue=6 |pages=763–73 |year=2007 |month=December |pmid=18042066 |doi=10.1111/j.1365-2559.2007.02883.x |url=}}</ref><ref name=pmid15967038>{{Cite journal  | last1 = Pahlavan | first1 = PS. | last2 = Kanthan | first2 = R. | title = Goblet cell carcinoid of the appendix. | journal = World J Surg Oncol | volume = 3 | issue =  | pages = 36 | month = Jun | year = 2005 | doi = 10.1186/1477-7819-3-36 | PMID = 15967038 }}</ref>  
and '''[[neuroendocrine tumour]] with goblet cell differentiation'''.


==General==
==General==
*Rare appendiceal tumour that typically has an aggressive course vis-a-vis other appendiceal carcinoids.<ref name=pmid18042066>{{cite journal |author=van Eeden S, Offerhaus GJ, Hart AA, ''et al.'' |title=Goblet cell carcinoid of the appendix: a specific type of carcinoma |journal=Histopathology |volume=51 |issue=6 |pages=763–73 |year=2007 |month=December |pmid=18042066 |doi=10.1111/j.1365-2559.2007.02883.x |url=}}</ref>
*Rare appendiceal tumour that typically has an aggressive course vis-à-vis [[appendiceal carcinoid]]s.<ref name=pmid18042066>{{cite journal |author=van Eeden S, Offerhaus GJ, Hart AA, ''et al.'' |title=Goblet cell carcinoid of the appendix: a specific type of carcinoma |journal=Histopathology |volume=51 |issue=6 |pages=763–73 |year=2007 |month=December |pmid=18042066 |doi=10.1111/j.1365-2559.2007.02883.x |url=}}</ref>
*Mixed (biphasic) tumour with endocrine and exocrine features.
*Mixed (biphasic) tumour with endocrine and exocrine features.
*Usually presents as [[acute appendicitis]].<ref name=pmid15967038/>
*Usually presents as [[acute appendicitis]].<ref name=pmid15967038/>
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==Gross==
==Gross==
*Typically no mass is apparent at gross.<ref name=pmid15967038/>
*Typically no mass is apparent at gross.<ref name=pmid15967038/>
Note:
*Should be [[submitted in total]].


==Microscopic==
==Microscopic==
Features:<ref name=pmid15967038>{{cite journal |author=Pahlavan PS, Kanthan R |title=Goblet cell carcinoid of the appendix |journal=World J Surg Oncol |volume=3 |issue= |pages=36 |year=2005 |month=June |pmid=15967038 |pmc=1182398 |doi=10.1186/1477-7819-3-36 |url=http://wjso.com/content/3/1/36}}</ref>
Features:<ref name=pmid15967038/>
*Mixed neuroendocrine-nonneuroendocrine tumour;<ref name=pmid17684764>{{cite journal |author=Volante M, Righi L, Asioli S, Bussolati G, Papotti M |title=Goblet cell carcinoids and other mixed neuroendocrine/nonneuroendocrine neoplasms |journal=Virchows Arch. |volume=451 Suppl 1 |issue= |pages=S61–9 |year=2007 |month=August |pmid=17684764 |doi=10.1007/s00428-007-0447-y |url=}}</ref> features of both ''carcinoid'' and ''adenocarcinoma.<ref name=pmid15967038/>
*Mixed neuroendocrine-nonneuroendocrine tumour;<ref name=pmid17684764>{{cite journal |author=Volante M, Righi L, Asioli S, Bussolati G, Papotti M |title=Goblet cell carcinoids and other mixed neuroendocrine/nonneuroendocrine neoplasms |journal=Virchows Arch. |volume=451 Suppl 1 |issue= |pages=S61–9 |year=2007 |month=August |pmid=17684764 |doi=10.1007/s00428-007-0447-y |url=}}</ref> features of both ''carcinoid'' and ''adenocarcinoma.<ref name=pmid15967038/>
**Archictecture: cells arranged in nests or clusters without a lumen.
**Archictecture: cells arranged in nests or clusters without a lumen.
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===Images===
===Images===
====Case 1====
<gallery>
<gallery>
Image:Goblet cell carcinoid - low mag.jpg| CCC - low mag. (WC/Nephron)
Image:Goblet cell carcinoid - low mag.jpg| CCC - low mag. (WC/Nephron)
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Image:Goblet cell carcinoid -2- high mag.jpg| CCC - high mag. (WC/Nephron)
Image:Goblet cell carcinoid -2- high mag.jpg| CCC - high mag. (WC/Nephron)
Image:Goblet cell carcinoid -2- very high mag.jpg| CCC - very high mag. (WC/Nephron)
Image:Goblet cell carcinoid -2- very high mag.jpg| CCC - very high mag. (WC/Nephron)
</gallery>
====Case 2====
<gallery>
Image:Appendix Carcinoid GobletCell HP PA.JPG|Goblet cell carcinoid - high power (SKB)
Image:Appendix Carcinoid GobletCell HP PA.JPG|Goblet cell carcinoid - high power (SKB)
Image:Appendix Carcinoid GobletCell HP (5) PA.JPG|Appendix - Goblet cell carcinoid - high power (SKB)
Image:Appendix Carcinoid GobletCell HP (5) PA.JPG|Appendix - Goblet cell carcinoid - high power (SKB)
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**Synaptophysin +ve.
**Synaptophysin +ve.
**Chromogranin +ve.
**Chromogranin +ve.
*S-100 +ve.
*[[S-100]] +ve.
*NSE +ve.
*NSE +ve.
*Serotonin +ve.
*Serotonin +ve.


Keratins:
Keratins:
*Usually CK20 +ve > CK7 +ve.
*Usually [[CK20]] +ve > [[CK7]] +ve.


*CEA +ve (membrane).
*CEA +ve (membrane).


Notes:
Notes:
*Nice review of stains in Pahlavan and Kanthan.<ref name=pmid15967038>{{cite journal |author=Pahlavan PS, Kanthan R |title=Goblet cell carcinoid of the appendix |journal=World J Surg Oncol |volume=3 |issue= |pages=36 |year=2005 |month=June |pmid=15967038 |pmc=1182398 |doi=10.1186/1477-7819-3-36 |url=http://wjso.com/content/3/1/36}}</ref>
*Review of stains in Pahlavan and Kanthan.<ref name=pmid15967038/>


==See also==
==See also==
Michael
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