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Difference between revisions of "Glomus tumour"
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It should not be confused with ''[[paraganglioma]]'', which were once called glomus tumour. | It should not be confused with ''[[paraganglioma]]'', which were once called glomus tumour. | ||
==General== | |||
*Tumour derived from smooth muscle cell.<ref name=pmid18788860>{{cite journal |author=Gombos Z, Zhang PJ |title=Glomus tumor |journal=Arch. Pathol. Lab. Med. |volume=132 |issue=9 |pages=1448–52 |year=2008 |month=September |pmid=18788860 |doi=10.1043/1543-2165(2008)132[1448:GT]2.0.CO;2 |url=}}</ref> | |||
*Usually benign. | |||
**Malignant variant exists - extremely rare. | |||
Clinical: | |||
*[[Painful skin lesion]]. | |||
==Microscopic== | ==Microscopic== | ||
Features:<ref name=ouhsc>URL: [http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/Z0B003-PQ01-M.htm http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/Z0B003-PQ01-M.htm]. Accessed on: 19 October 2010.</ref> | Features:<ref name=ouhsc>URL: [http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/Z0B003-PQ01-M.htm http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/Z0B003-PQ01-M.htm]. Accessed on: 19 October 2010.</ref> | ||
*Sheets of polygonal epithelioid cells with | *Sheets of equally-spaced polygonal epithelioid cells. | ||
**The regular spacing is called "cookie cutter" appearance. It looks like the cells were created with a cookie cutter; the spacing is equal and they all look very similar. | |||
*Thin-walled blood vessels. | |||
*No significant nuclear atypia. | *No significant nuclear atypia. | ||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:Glomus_tumour_-_intermed_mag.jpg Glomus tumour - intermed. mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Glomus_tumour_-_2_-_very_high_mag.jpg Glomus tumour - very high mag. (WC)]. | |||
*[http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/Z0B003-PQ01-M.htm Glomus tumour (ouhsc.edu)]. | *[http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/Z0B003-PQ01-M.htm Glomus tumour (ouhsc.edu)]. | ||
===IHC=== | |||
Features:<ref name=pmid9362106>{{cite journal |author=Hatori M, Aiba S, Kato M, Kamiya N, Kokubun S |title=Expression of CD34 in glomus tumors |journal=Tohoku J. Exp. Med. |volume=182 |issue=3 |pages=241–7 |year=1997 |month=July |pmid=9362106 |doi= |url=}}</ref> | |||
*SMA +ve ~ 100%. | |||
*Desmin usu. -ve. | |||
*CD34 -ve. | |||
**Rarely +ve. | |||
Others: | |||
*S100 -ve. | |||
===Other diagnoses... === | ===Other diagnoses... === | ||
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*[[Angiosarcoma]] - has nuclear atypia. | *[[Angiosarcoma]] - has nuclear atypia. | ||
*[[Dermatofibroma]] - spindle cell lesion. | *[[Dermatofibroma]] - spindle cell lesion. | ||
*Capillary hemangioma - no epithelioid cells, more blood vessels. | *[[Capillary hemangioma]] - no epithelioid cells, more blood vessels. | ||
==See also== | ==See also== | ||