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Difference between revisions of "Giant cell cystitis"
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'''Giant cell cystitis''' is term used for a benign change of | [[Image:Bladder with benign large mesenchymal cells -- high mag.jpg|thumb|right|300px|Urinary bladder with benign large mesenchymal cells - so-called "giant cell cystitis". [[H&E stain]].]] | ||
'''Giant cell cystitis''' is term used for a benign change of mesenchymal cells in the [[urinary bladder]] lamina propria. | |||
''Giant cell cystitis'' is considered a misnomer as may be seen in an otherwise normal bladder.<ref name=pmid20196670>{{Cite journal | last1 = Hameed | first1 = O. | last2 = Humphrey | first2 = PA. | title = Pseudoneoplastic mimics of prostate and bladder carcinomas. | journal = Arch Pathol Lab Med | volume = 134 | issue = 3 | pages = 427-43 | month = Mar | year = 2010 | doi = 10.1043/1543-2165-134.3.427 | PMID = 20196670 }}</ref> | ''Giant cell cystitis'' is considered a misnomer as it may be seen in an otherwise normal bladder that lacks significant inflammation.<ref name=pmid20196670>{{Cite journal | last1 = Hameed | first1 = O. | last2 = Humphrey | first2 = PA. | title = Pseudoneoplastic mimics of prostate and bladder carcinomas. | journal = Arch Pathol Lab Med | volume = 134 | issue = 3 | pages = 427-43 | month = Mar | year = 2010 | doi = 10.1043/1543-2165-134.3.427 | PMID = 20196670 }}</ref> | ||
==General== | ==General== | ||
*Considered a common benign finding; ''not'' a clinical entity.<ref name=Ref_Amin2_6>{{Ref Amin|2:6}}</ref> | *Considered a common benign finding; ''not'' a clinical entity.<ref name=Ref_Amin2_6>{{Ref Amin|2:6}}</ref> | ||
*Reported in up to 1/3 of bladders at [[autopsy]].<ref>{{Cite journal | last1 = Wells | first1 = HG | last2 = | first2 = | title = Giant cells in cystitis | journal = Arch Pathol | volume = 26 | issue = | pages = 32-43 | month = | year = 1938 | doi = | PMID = | PMC = | url = }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
Features:<ref name=Ref_Uropath305>{{Ref Uropath|305}}</ref> | Features:<ref name=Ref_Uropath305>{{Ref Uropath|305}}</ref> | ||
*Scattered atypical mesenchymal cells - mononuclear or multinucleated. | *Scattered atypical mesenchymal cells - mononuclear or multinucleated - '''key feature'''. | ||
*+/-Nuclear hyperchromasia and/or lobulation. | *+/-Nuclear hyperchromasia and/or lobulation. | ||
* | *Minimal/absence of mitotic activity. | ||
Note: | |||
*Inflammation may be present or absent; "giant cell cystitis" is a misnomer. | |||
DDx: | DDx: | ||
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*[[Sarcoma]] of the bladder or metastatic sarcoma - typically more cellular.<ref name=Ref_Amin2_6/> | *[[Sarcoma]] of the bladder or metastatic sarcoma - typically more cellular.<ref name=Ref_Amin2_6/> | ||
*Sarcomatoid change in [[urothelial carcinoma]]. | *Sarcomatoid change in [[urothelial carcinoma]]. | ||
===Images=== | |||
<gallery> | |||
Image: Bladder with benign large mesenchymal cells -- very low mag.jpg | GCC - very low mag. (WC) | |||
Image: Bladder with benign large mesenchymal cells -- low mag.jpg | GCC - low mag. (WC) | |||
Image: Bladder with benign large mesenchymal cells -- intermed mag.jpg | GCC - intermed. mag. (WC) | |||
Image: Bladder with benign large mesenchymal cells -- high mag.jpg | GCC - high mag. (WC) | |||
Image: Bladder with benign large mesenchymal cells - alt -- intermed mag.jpg | GCC - intermed. mag. (WC) | |||
Image: Bladder with benign large mesenchymal cells - alt -- high mag.jpg | GCC - high mag. (WC) | |||
Image: Bladder with benign large mesenchymal cells - alt -- very high mag.jpg | GCC - very high mag. (WC) | |||
Image: Bladder with benign large mesenchymal cells -- very high mag.jpg | GCC - very high mag. (WC) | |||
</gallery> | |||
==Sign out== | ==Sign out== | ||
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- NEGATIVE for significant proliferative activity and NEGATIVE for significant inflammation. | - NEGATIVE for significant proliferative activity and NEGATIVE for significant inflammation. | ||
- NEGATIVE for dysplasia and NEGATIVE for malignancy. | - NEGATIVE for dysplasia and NEGATIVE for malignancy. | ||
</pre> | </pre> | ||
==See also== | ==See also== | ||
*[[Radiation cystitis]]. | *[[Radiation cystitis]]. | ||
*[[Giant cells]]. | |||
==References== | ==References== | ||