Difference between revisions of "Germ cell tumours"

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Germ cell tumours (view source)

Revision as of 01:13, 20 May 2013

369 bytes removed ,  01:13, 20 May 2013
+images
(+images)
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| CD117
| CD117
| appearance similar to seminoma
| appearance similar to seminoma
| [http://commons.wikimedia.org/wiki/File:Intratubular_germ_cell_neoplasia_high_mag.jpg], [http://commons.wikimedia.org/wiki/File:Intratubular_germ_cell_neoplasia_high_mag_cropped.jpg]
| [[Image:Intratubular_germ_cell_neoplasia_high_mag_cropped.jpg|thumb|center|150px|ITGCN (WC/Nephron)]]
|-  
|-  
| Germinoma / Seminoma / Dysgerminoma
| Germinoma / Seminoma / Dysgerminoma
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| D2-40
| D2-40
| seminoma = male version of this tumour; dysgerminoma = female version of this tumour
| seminoma = male version of this tumour; dysgerminoma = female version of this tumour
| [http://commons.wikimedia.org/wiki/File:Seminoma_high_mag.jpg], [http://commons.wikimedia.org/wiki/File:Seminoma_intermed_mag.jpg]
| [[Image:Seminoma_intermed_mag.jpg|thumb|center|150px|Seminoma (WC/Nephron)]]
|-  
|-  
| [[Yolk sac tumour]] (endodermal sinus tumour)
| [[Yolk sac tumour]] (endodermal sinus tumour)
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| AFP
| AFP
| patterns: microcystic, solid, hepatoid
| patterns: microcystic, solid, hepatoid
| [http://webpathology.com/image.asp?case=34&n=6 hepatoid YST]
| [[Image:Mixed_germ_cell_tumour_-_very_high_mag.jpg|thumb|center|150px|Yolk sac tumour (WC)]]
|-  
|-  
| [[Embryonal carcinoma]]
| [[Embryonal carcinoma]]
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| CD30
| CD30
| usu. part of a mixed GCT  
| usu. part of a mixed GCT  
| [http://commons.wikimedia.org/wiki/File:Embryonal_carcinoma_intermed_mag.jpg], [http://www.webpathology.com/image.asp?case=33&n=1], [http://www.webpathology.com/image.asp?n=4&Case=37]
| [[Image:Embryonal_carcinoma_high_mag.jpg|thumb|center|150px|Embryonal carcinoma (WC/Nephron)]]
|-  
|-  
| [[Choriocarcinoma]]
| [[Choriocarcinoma]]
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| beta-hCG
| beta-hCG
| may be preceded by a [[complete mole|complete hydatidiform mole]]
| may be preceded by a [[complete mole|complete hydatidiform mole]]
| [http://www.webpathology.com/image.asp?case=36&n=1], [http://www.webpathology.com/image.asp?n=2&Case=36]
| [[Image:Choriocarcinoma_-2-_very_high_mag.jpg|thumb|center|150px|Choriocarcinoma. (WC/Nephron)]]
|-  
|-  
| [[Teratoma]], immature
| [[Teratoma]], immature
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| None
| None
| teratoma are always malignant in males
| teratoma are always malignant in males
| [http://commons.wikimedia.org/wiki/File:Primitive_neuroepithelium_intermed_mag.jpg]
| [[Image:Primitive_neuroepithelium_intermed_mag.jpg|thumb|center|150px|Primitive neuroepithelium (WC/Nephron)]]
|-  
|-  
| [[Mixed germ cell tumour]]
| [[Mixed germ cell tumour]]
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| NA
| NA
| -
| -
| [http://commons.wikimedia.org/wiki/File:Mixed_germ_cell_tumour_-_intermed_mag.jpg]
| [[Image:Mixed_germ_cell_tumour_-_intermed_mag.jpg|thumb|center|150px|Mixed GCT (WC/Nephron)]]
|-  
|-  
| [[Gonadoblastoma]]
| [[Gonadoblastoma]]
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| ?
| ?
| often abnormal karyotype; usu. Y chromosome present
| often abnormal karyotype; usu. Y chromosome present
| [http://commons.wikimedia.org/wiki/File:Gonadoblastoma_-_intermed_mag.jpg]
| [[Image:Gonadoblastoma_-_intermed_mag.jpg|thumb|center|150px|Gonadoblastoma (WC/Nephron)]
|}
|}


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*[[Embryonal carcinoma]].
*[[Embryonal carcinoma]].


Images:
====Images====
<gallery>
Image:Mixed_germ_cell_tumour_-_very_high_mag.jpg|Yolk sac tumour. (WC/Nephron)
</gallery>
www:
*[http://webpathology.com/image.asp?case=34&n=6 Hepatoid Pattern (webpathology.com)].
*[http://webpathology.com/image.asp?case=34&n=6 Hepatoid Pattern (webpathology.com)].
*[http://www.webpathology.com/image.asp?case=34&n=5 Schiller-Duval body (webpathology.com)].
*[http://www.webpathology.com/image.asp?case=34&n=5 Schiller-Duval body (webpathology.com)].
Line 219: Line 223:
*[[Yolk sac tumour]].
*[[Yolk sac tumour]].


Images:
====Images====
*Set 1:
<gallery>
**[http://commons.wikimedia.org/wiki/File:Embryonal_carcinoma_-_very_high_mag_-_cropped.jpg Embryonal carcinoma - very high mag. - cropped (WC)].
Image:Embryonal_carcinoma_-_very_high_mag_-_cropped.jpg | Embryonal carcinoma - very high mag. - cropped (WC/Nephron)
**[http://commons.wikimedia.org/wiki/File:Embryonal_carcinoma_-_high_mag.jpg Embryonal carcinoma - high mag. (WC)].
Image:Embryonal_carcinoma_-_high_mag.jpg | Embryonal carcinoma - high mag. (WC/Nephron)
*Set 2:
</gallery>
**[http://commons.wikimedia.org/wiki/File:Embryonal_carcinoma_high_mag.jpg Embryonal carcinoma - high mag. (WC)].
<gallery>
**[http://commons.wikimedia.org/wiki/File:Embryonal_carcinoma_intermed_mag.jpg Embryonal carcinoma - intermed. mag. (WC)].
Image:Embryonal_carcinoma_high_mag.jpg | Embryonal carcinoma - high mag. (WC/Nephron)
**[http://commons.wikimedia.org/wiki/File:Embryonal_carcinoma_low_mag.jpg Embryonal carcinoma - low mag. (WC)].
Image:Embryonal_carcinoma_intermed_mag.jpg | Embryonal carcinoma - intermed. mag. (WC/Nephron)
 
Image:Embryonal_carcinoma_low_mag.jpg | Embryonal carcinoma - low mag. (WC/Nephron)
</gallery>
===IHC===
===IHC===
*AE1/AE3 +ve.
*AE1/AE3 +ve.
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*[[Placental site trophoblastic tumour]] (PSTT).
*[[Placental site trophoblastic tumour]] (PSTT).


Images:
====Images====
*www:
www:
**[http://www.webpathology.com/image.asp?n=5&Case=36 Choriocarcinoma - low mag. (webpathology.com)].
*[http://www.webpathology.com/image.asp?n=5&Case=36 Choriocarcinoma - low mag. (webpathology.com)].
**[http://www.webpathology.com/image.asp?case=36&n=1 Choriocarcinoma (webpathology.com)].
*[http://www.webpathology.com/image.asp?case=36&n=1 Choriocarcinoma (webpathology.com)].
**[http://www.webpathology.com/image.asp?n=4&Case=36 Choriocarcinoma (webpathology.com)].
*[http://www.webpathology.com/image.asp?n=4&Case=36 Choriocarcinoma (webpathology.com)].
**[http://chestjournal.chestpubs.org/content/138/1/220.full Choriocarcinoma (chestjournal.chestpubs.org)].<ref>{{Cite journal  | last1 = Venkatram | first1 = S. | last2 = Muppuri | first2 = S. | last3 = Niazi | first3 = M. | last4 = Fuentes | first4 = GD. | title = A 24-year-old pregnant patient with diffuse alveolar hemorrhage. | journal = Chest | volume = 138 | issue = 1 | pages = 220-3 | month = Jul | year = 2010 | doi = 10.1378/chest.09-2688 | PMID = 20605823 }}</ref>
*[http://chestjournal.chestpubs.org/content/138/1/220.full Choriocarcinoma (chestjournal.chestpubs.org)].<ref>{{Cite journal  | last1 = Venkatram | first1 = S. | last2 = Muppuri | first2 = S. | last3 = Niazi | first3 = M. | last4 = Fuentes | first4 = GD. | title = A 24-year-old pregnant patient with diffuse alveolar hemorrhage. | journal = Chest | volume = 138 | issue = 1 | pages = 220-3 | month = Jul | year = 2010 | doi = 10.1378/chest.09-2688 | PMID = 20605823 }}</ref>
**[http://oac.med.jhmi.edu/Pathology/Repro/Placenta/279B_Full.html Choriocarcinoma - uterus (med.jhmi.edu)].
*[http://oac.med.jhmi.edu/Pathology/Repro/Placenta/279B_Full.html Choriocarcinoma - uterus (med.jhmi.edu)].
*[[WC]]:
<gallery>
**[http://commons.wikimedia.org/wiki/File:Choriocarcinoma_-2-_high_mag.jpg Choriocarcinoma - high mag. (WC)].
Image:Choriocarcinoma_-2-_high_mag.jpg | Choriocarcinoma - high mag. (WC/Nephron)
**[http://commons.wikimedia.org/wiki/File:Choriocarcinoma_-2-_very_high_mag.jpg Choriocarcinoma - very high mag. (WC)].
Image:Choriocarcinoma_-2-_very_high_mag.jpg | Choriocarcinoma - very high mag. (WC/Nephron)
 
</gallery>
===IHC===
===IHC===
*Beta-hCG +ve.
*Beta-hCG +ve.
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*May consist of skin only - in which case it is commonly called a ''dermoid''.
*May consist of skin only - in which case it is commonly called a ''dermoid''.


Images:
=====Images=====
*[http://commons.wikimedia.org/wiki/File:Teratoma_2_low_mag.jpg Mature teratoma - low mag. (WC)].
<gallery>
*[http://commons.wikimedia.org/wiki/File:Teratoma_2_high_mag.jpg Mature teratoma - high mag. (WC)].
Image:Teratoma_2_low_mag.jpg | Mature teratoma - low mag. (WC/Nephron)
Image:Teratoma_2_high_mag.jpg | Mature teratoma - high mag. (WC/Nephron)
</gallery>


====Fetus in fetu====
====Fetus in fetu====
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*[[Retina]].
*[[Retina]].


Images:
=====Images=====
*[http://commons.wikimedia.org/wiki/File:Immature_teratoma_high_mag.jpg Primitive neuroepithelium - high mag. (WC)].
<gallery>
*[http://commons.wikimedia.org/wiki/File:Primitive_neuroepithelium_intermed_mag.jpg Primitive neuroepithelium - intermed mag. (WC)]
Image:Immature_teratoma_high_mag.jpg | Primitive neuroepithelium - high mag. (WC/Nephron)
*[http://commons.wikimedia.org/wiki/File:Teratoma_intermed_mag.jpg Teratoma - mature components (WC)].
Image:Primitive_neuroepithelium_intermed_mag.jpg | Primitive neuroepithelium - intermed mag. (WC/Nephron)
Image:Teratoma_intermed_mag.jpg | Teratoma - mature components (WC/Nephron)
</gallery>


Other images:
Other images:
Line 386: Line 395:
**May develop pathologies seen in the [[thyroid gland]], e.g. [[papillary thyroid carcinoma]].
**May develop pathologies seen in the [[thyroid gland]], e.g. [[papillary thyroid carcinoma]].


Images:
=====Images=====
*[http://commons.wikimedia.org/wiki/File:Struma_ovarii_-_low_mag.jpg Struma ovarii - low mag. (WC)].
<gallery>
*[http://commons.wikimedia.org/wiki/File:Struma_ovarii_-_high_mag.jpg Struma ovarii - high mag. (WC)].
Image:Struma_ovarii_-_low_mag.jpg | Struma ovarii - low mag. (WC/Nephron)
 
Image:Struma_ovarii_-_high_mag.jpg | Struma ovarii - high mag. (WC/Nephron)
</gallery>
====Strumal carcinoid====
====Strumal carcinoid====
Features:<ref name=pmid18509188>{{Cite journal  | last1 = Gorin | first1 = I. | last2 = Sastre-Garau | first2 = X. | title = Strumal carcinoid tumor of the ovary. | journal = J Clin Oncol | volume = 26 | issue = 16 | pages = 2780-1 | month = Jun | year = 2008 | doi = 10.1200/JCO.2008.16.1620 | PMID = 18509188 }}</ref><ref>{{Cite journal  | last1 = Tamsen | first1 = A. | last2 = Mazur | first2 = MT. | title = Ovarian strumal carcinoid in association with multiple endocrine neoplasia, type IIA. | journal = Arch Pathol Lab Med | volume = 116 | issue = 2 | pages = 200-3 | month = Feb | year = 1992 | doi =  | PMID = 1346363 }}</ref>
Features:<ref name=pmid18509188>{{Cite journal  | last1 = Gorin | first1 = I. | last2 = Sastre-Garau | first2 = X. | title = Strumal carcinoid tumor of the ovary. | journal = J Clin Oncol | volume = 26 | issue = 16 | pages = 2780-1 | month = Jun | year = 2008 | doi = 10.1200/JCO.2008.16.1620 | PMID = 18509188 }}</ref><ref>{{Cite journal  | last1 = Tamsen | first1 = A. | last2 = Mazur | first2 = MT. | title = Ovarian strumal carcinoid in association with multiple endocrine neoplasia, type IIA. | journal = Arch Pathol Lab Med | volume = 116 | issue = 2 | pages = 200-3 | month = Feb | year = 1992 | doi =  | PMID = 1346363 }}</ref>
Line 397: Line 407:
*#[[Thyroid]] - cystic spaces/follicular-like structures.
*#[[Thyroid]] - cystic spaces/follicular-like structures.


Images:
=====Images=====
*[http://commons.wikimedia.org/wiki/File:Strumal_carcinoid_-_intermed_mag.jpg Strumal carcinoid - intermed. mag. (WC)].
<gallery>
*[http://commons.wikimedia.org/wiki/File:Strumal_carcinoid_-_high_mag.jpg Strumal carcinoid - high mag. (WC)].
Image:Strumal_carcinoid_-_intermed_mag.jpg | Strumal carcinoid - intermed. mag. (WC/Nephron)
 
Image:Strumal_carcinoid_-_high_mag.jpg | Strumal carcinoid - high mag. (WC/Nephron)
</gallery>
==Gonadoblastoma==
==Gonadoblastoma==
===General===
===General===
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*+/-Eosinophilic basement membrane material between the (primitive) germ cells and support cells.<ref>URL: [http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/ http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/]. Accessed on: 11 September 2011.</ref>
*+/-Eosinophilic basement membrane material between the (primitive) germ cells and support cells.<ref>URL: [http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/ http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/]. Accessed on: 11 September 2011.</ref>


Images:
====Images====
*www:
www:
**[http://www.webpathology.com/image.asp?n=40&Case=532 Gonadoblastoma - low mag. (webpathology.com)].
*[http://www.webpathology.com/image.asp?n=40&Case=532 Gonadoblastoma - low mag. (webpathology.com)].
**[http://www.webpathology.com/image.asp?case=532&n=42 Gonadoblastoma - high mag. (webpathology.com)].
*[http://www.webpathology.com/image.asp?case=532&n=42 Gonadoblastoma - high mag. (webpathology.com)].
**[http://www.webpathology.com/image.asp?case=532&n=44 Gonadoblastoma - high mag. (webpathology.com)].
*[http://www.webpathology.com/image.asp?case=532&n=44 Gonadoblastoma - high mag. (webpathology.com)].
**[http://www.flickr.com/photos/ckrishnan/3972431774/in/photostream/ Gonadoblastoma - low mag. (flickr.com)].
*[http://www.flickr.com/photos/ckrishnan/3972431774/in/photostream/ Gonadoblastoma - low mag. (flickr.com)].
**[http://www.flickr.com/photos/ckrishnan/3972432404/in/photostream/ Gonadoblastoma - intermed. mag. (flickr.com)].
*[http://www.flickr.com/photos/ckrishnan/3972432404/in/photostream/ Gonadoblastoma - intermed. mag. (flickr.com)].
**[http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/ Gonadoblastoma - high mag. (flickr.com)].
*[http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/ Gonadoblastoma - high mag. (flickr.com)].
**[http://path.upmc.edu/cases/case356.html Gonadoblastoma - several cases (upmc.edu)].
*[http://path.upmc.edu/cases/case356.html Gonadoblastoma - several cases (upmc.edu)].
*[[WC]]:
<gallery>
**[http://commons.wikimedia.org/wiki/File:Gonadoblastoma_-_intermed_mag.jpg Gonadoblastoma - intermed. mag. (WC)].
Image:Gonadoblastoma_-_intermed_mag.jpg | Gonadoblastoma - intermed. mag. (WC/Nephron)
**[http://commons.wikimedia.org/wiki/File:Gonadoblastoma_-_b_-_high_mag.jpg Gonadoblastoma - high mag. (WC)].
Image:Gonadoblastoma_-_b_-_high_mag.jpg | Gonadoblastoma - high mag. (WC/Nephron)
 
</gallery>
==Polyembryoma==
==Polyembryoma==
===General===
===General===
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*If one cannot identify the component... it is probably yolk sac as this has so many different patterns.
*If one cannot identify the component... it is probably yolk sac as this has so many different patterns.


Images:
====Images====
*[[WC]]:
<gallery>
**[http://commons.wikimedia.org/wiki/File:Mixed_germ_cell_tumour_-_intermed_mag.jpg Mixed germ cell tumour - intermed mag. (WC)].
Image:Mixed_germ_cell_tumour_-_intermed_mag.jpg | Mixed germ cell tumour - intermed mag. (WC/Nephron)
*www:
</gallery>
**[http://path.upmc.edu/cases/case192/micro.html Mixed germ cell tumour - several images (upmc.edu)].
www:
**[http://path.upmc.edu/cases/case356.html Mixed germ cell tumour - several cases (upmc.edu)].
*[http://path.upmc.edu/cases/case192/micro.html Mixed germ cell tumour - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case356.html Mixed germ cell tumour - several cases (upmc.edu)].


===IHC===
===IHC===
Michael
48,466

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