Difference between revisions of "Gene fusion"
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* duplication. | * duplication. | ||
* inversion. | * inversion. | ||
First fusion was described as BCR-ABL1 fusion in [[CML]]. Subsequently [[Imatinib]] was the first inhibitor targeting CML with BCR-ABL1 fusion. | |||
Revision as of 08:13, 4 October 2018
Gene fusion is a common event in cancer and a re-occuring theme in molecular pathology. It is hybrid of two coding or regulatory DNA sequences.
General
Caused by genomic rearrangements such as:
- translocation.
- deletion.
- duplication.
- inversion.
First fusion was described as BCR-ABL1 fusion in CML. Subsequently Imatinib was the first inhibitor targeting CML with BCR-ABL1 fusion.