Difference between revisions of "Gallbladder adenoma"
Jump to navigation
Jump to search
| Line 23: | Line 23: | ||
*Low grade dysplasia should prompt targeted sampling and review.<ref name=uscap2017_akki/> | *Low grade dysplasia should prompt targeted sampling and review.<ref name=uscap2017_akki/> | ||
*Gallbladders with high grade dysplasia should be [[submitted in total]] to exclude [[gallbladder adenocarcinoma]].<ref name=uscap2017_akki>Akki ''et al.'' (2017) "Detecting Incidental Gallbladder Adenocarcinoma: When to Submit the Entire Gallbladder". Available at: [http://www.abstracts2view.com/uscap17/view.php?nu=USCAP17L_2016 http://www.abstracts2view.com/uscap17/view.php?nu=USCAP17L_2016]. United States and Canadian Academy of Pathology Annual Meeting. Accessed on: April 9, 2017.</ref> | *Gallbladders with high grade dysplasia should be [[submitted in total]] to exclude [[gallbladder adenocarcinoma]].<ref name=uscap2017_akki>Akki ''et al.'' (2017) "Detecting Incidental Gallbladder Adenocarcinoma: When to Submit the Entire Gallbladder". Available at: [http://www.abstracts2view.com/uscap17/view.php?nu=USCAP17L_2016 http://www.abstracts2view.com/uscap17/view.php?nu=USCAP17L_2016]. United States and Canadian Academy of Pathology Annual Meeting. Accessed on: April 9, 2017.</ref> | ||
Grading:<ref name=pmid33629395>{{cite journal |vauthors=Roa JC, Basturk O, Adsay V |title=Dysplasia and carcinoma of the gallbladder: pathological evaluation, sampling, differential diagnosis and clinical implications |journal=Histopathology |volume=79 |issue=1 |pages=2–19 |date=July 2021 |pmid=33629395 |doi=10.1111/his.14360 |url=}}</ref> | |||
*Low-grade. | |||
*High-grade. | |||
DDx: | DDx: | ||
Revision as of 20:41, 1 October 2021
Gallbladder adenoma is a pre-malignant lesion of the gallbladder.
Gallbladder dysplasia redirects here.
General
- Premalignant lesion.
- May be associated with familial adenomatous polyposis or Peutz-Jeghers syndrome.[1]
Microscopic
Features:
- Gallbladder epithelium with:
- Nuclear atypia - key feature.
- Nuclear hyperchromasia.
- Nuclear crowding (pseudostratification) or round enlarged nuclei.
- +/-Goblet cells.
- Nuclear atypia - key feature.
Architectural subclassification:[2]
- Papillary ~ 45%.
- Tubulopapillary ~ 30%.
- Tubular ~ 25%.
Notes:
- Low grade dysplasia should prompt targeted sampling and review.[3]
- Gallbladders with high grade dysplasia should be submitted in total to exclude gallbladder adenocarcinoma.[3]
Grading:[4]
- Low-grade.
- High-grade.
DDx:
- Gallbladder adenocarcinoma.
- Reactive changes.
Images
- Tubular adenoma, biliary type (rsna.org).[1]
- Gallbladder with high-grade dysplasia (flickr.com/lunar caustic).
Sign out
GALLBLADDER, CHOLECYSTECTOMY: - BILIARY TYPE TUBULAR ADENOMA WITH HIGH GRADE DYSPLASIA. - MARGINS CLEAR OF ADENOMA (NEAREST MARGIN 1.0 CM).
See also
References
- ↑ 1.0 1.1 Levy, AD.; Murakata, LA.; Abbott, RM.; Rohrmann, CA.. "From the archives of the AFIP. Benign tumors and tumorlike lesions of the gallbladder and extrahepatic bile ducts: radiologic-pathologic correlation. Armed Forces Institute of Pathology.". Radiographics 22 (2): 387-413. PMID 11896229. http://radiographics.rsna.org/content/22/2/387.full.
- ↑ Adsay, V.; Jang, KT.; Roa, JC.; Dursun, N.; Ohike, N.; Bagci, P.; Basturk, O.; Bandyopadhyay, S. et al. (Sep 2012). "Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.". Am J Surg Pathol 36 (9): 1279-301. doi:10.1097/PAS.0b013e318262787c. PMID 22895264.
- ↑ 3.0 3.1 Akki et al. (2017) "Detecting Incidental Gallbladder Adenocarcinoma: When to Submit the Entire Gallbladder". Available at: http://www.abstracts2view.com/uscap17/view.php?nu=USCAP17L_2016. United States and Canadian Academy of Pathology Annual Meeting. Accessed on: April 9, 2017.
- ↑ "Dysplasia and carcinoma of the gallbladder: pathological evaluation, sampling, differential diagnosis and clinical implications". Histopathology 79 (1): 2–19. July 2021. doi:10.1111/his.14360. PMID 33629395.