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Difference between revisions of "GATA3"
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gata3 in Pca
(gata3 in Pca) |
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| Abbrev = | | Abbrev = | ||
| Synonyms = | | Synonyms = | ||
| Similar = [[thrombomodulin]], | | Similar = [[thrombomodulin]], mammaglobin | ||
| Clones = | | Clones = | ||
| Use = bladder versus prostate, bladder versus SCC, breast versus other, parathyroid versus thyroid | | Use = bladder versus prostate, bladder versus SCC, breast versus other, parathyroid versus thyroid | ||
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*Most [[T-lymphocytes]].<ref name=pmid19151747>{{cite journal |authors=Ho IC, Tai TS, Pai SY |title=GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation |journal=Nat. Rev. Immunol. |volume=9 |issue=2 |pages=125–35 |date=February 2009 |pmid=19151747 |pmc=2998182 |doi=10.1038/nri2476 |url=}}</ref> Used as part of a wider panel of IHC to sub-type peripheral T-cell lymphoma, NOS.<ref name=pmid31562134>{{cite journal |authors=Amador C, Greiner TC, Heavican TB, Smith LM, Galvis KT, Lone W, Bouska A, D'Amore F, Pedersen MB, Pileri S, Agostinelli C, Feldman AL, Rosenwald A, Ott G, Mottok A, Savage KJ, de Leval L, Gaulard P, Lim ST, Ong CK, Ondrejka SL, Song J, Campo E, Jaffe ES, Staudt LM, Rimsza LM, Vose J, Weisenburger DD, Chan WC, Iqbal J |title=Reproducing the molecular subclassification of peripheral T-cell lymphoma-NOS by immunohistochemistry |journal=Blood |volume=134 |issue=24 |pages=2159–2170 |date=December 2019 |pmid=31562134 |doi=10.1182/blood.2019000779 |url=}}</ref> | *Most [[T-lymphocytes]].<ref name=pmid19151747>{{cite journal |authors=Ho IC, Tai TS, Pai SY |title=GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation |journal=Nat. Rev. Immunol. |volume=9 |issue=2 |pages=125–35 |date=February 2009 |pmid=19151747 |pmc=2998182 |doi=10.1038/nri2476 |url=}}</ref> Used as part of a wider panel of IHC to sub-type peripheral T-cell lymphoma, NOS.<ref name=pmid31562134>{{cite journal |authors=Amador C, Greiner TC, Heavican TB, Smith LM, Galvis KT, Lone W, Bouska A, D'Amore F, Pedersen MB, Pileri S, Agostinelli C, Feldman AL, Rosenwald A, Ott G, Mottok A, Savage KJ, de Leval L, Gaulard P, Lim ST, Ong CK, Ondrejka SL, Song J, Campo E, Jaffe ES, Staudt LM, Rimsza LM, Vose J, Weisenburger DD, Chan WC, Iqbal J |title=Reproducing the molecular subclassification of peripheral T-cell lymphoma-NOS by immunohistochemistry |journal=Blood |volume=134 |issue=24 |pages=2159–2170 |date=December 2019 |pmid=31562134 |doi=10.1182/blood.2019000779 |url=}}</ref> | ||
*[[Skin squamous cell carcinoma]].<ref name=pmid26595821>{{cite journal |authors=Mertens RB, de Peralta-Venturina MN, Balzer BL, Frishberg DP |title=GATA3 Expression in Normal Skin and in Benign and Malignant Epidermal and Cutaneous Adnexal Neoplasms |journal=Am J Dermatopathol |volume=37 |issue=12 |pages=885–91 |date=December 2015 |pmid=26595821 |pmc=4894790 |doi=10.1097/DAD.0000000000000306 |url=}}</ref> | *[[Skin squamous cell carcinoma]].<ref name=pmid26595821>{{cite journal |authors=Mertens RB, de Peralta-Venturina MN, Balzer BL, Frishberg DP |title=GATA3 Expression in Normal Skin and in Benign and Malignant Epidermal and Cutaneous Adnexal Neoplasms |journal=Am J Dermatopathol |volume=37 |issue=12 |pages=885–91 |date=December 2015 |pmid=26595821 |pmc=4894790 |doi=10.1097/DAD.0000000000000306 |url=}}</ref> | ||
*[[Clear cell tubulopapillary renal cell carcinoma]].<ref name=pmid28705707>{{cite journal |authors=Mantilla JG, Antic T, Tretiakova M |title=GATA3 as a valuable marker to distinguish clear cell papillary renal cell carcinomas from morphologic mimics |journal=Hum Pathol |volume=66 |issue= |pages=152–158 |date=August 2017 |pmid=28705707 |doi=10.1016/j.humpath.2017.06.016 |url=}}</ref> | |||
===Images=== | ===Images=== | ||
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*[[Prostate carcinoma]]. | *[[Prostate carcinoma]]. | ||
**Positive in benign prostate glands with radiation atypia.<ref name=pmid28316088>{{cite journal |authors=Tian W, Dorn D, Wei S, Sanders RD, Matoso A, Shah RB, Gordetsky J |title=GATA3 expression in benign prostate glands with radiation atypia: a diagnostic pitfall |journal=Histopathology |volume=71 |issue=1 |pages=150–155 |date=July 2017 |pmid=28316088 |doi=10.1111/his.13214 |url=}}</ref> | **Positive in benign prostate glands with radiation atypia.<ref name=pmid28316088>{{cite journal |authors=Tian W, Dorn D, Wei S, Sanders RD, Matoso A, Shah RB, Gordetsky J |title=GATA3 expression in benign prostate glands with radiation atypia: a diagnostic pitfall |journal=Histopathology |volume=71 |issue=1 |pages=150–155 |date=July 2017 |pmid=28316088 |doi=10.1111/his.13214 |url=}}</ref> | ||
**Positive staining may be seen in prostatic adenocarcinoma.<ref name=pmid32769430>{{cite journal |vauthors=McDonald TM, Epstein JI |title=Aberrant GATA3 Staining in Prostatic Adenocarcinoma: A Potential Diagnostic Pitfall |journal=Am J Surg Pathol |volume=45 |issue=3 |pages=341–346 |date=March 2021 |pmid=32769430 |doi=10.1097/PAS.0000000000001557 |url=}}</ref> | |||
*[[Squamous cell carcinoma of the lung]].<ref name=pmid22982890/> | *[[Squamous cell carcinoma of the lung]].<ref name=pmid22982890/> | ||