Difference between revisions of "GATA3"

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GATA3 (view source)

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{{ Infobox immunostain
| Name      = {{PAGENAME}}
| Image      = Benign urothelium - GATA3 -- high mag.jpg
| Width      =
| Caption    = GATA3 staining in benign [[urothelium]].
| Abbrev    =
| Synonyms  =
| Similar    = [[thrombomodulin]]
| Clones    =     
| Use        = bladder versus prostate, bladder versus SCC
| Subspecial = [[Genitourinary pathology]], [[Breast pathology]]
| Pattern    = nuclear
| Positive  = [[urothelial carcinoma]], [[invasive ductal carcinoma of the breast]], [[lobular breast carcinoma]]
| Negative  = [[prostatic carcinoma]], [[squamous cell carcinoma of the lung]]
| Other      =
}}
'''GATA3''' an [[immunostain]] that is increasingly used in [[genitourinary pathology]].  
'''GATA3''' an [[immunostain]] that is increasingly used in [[genitourinary pathology]].  


Positive:
==Positive==
*[[Urothelial carcinoma]].<ref name=pmid22982890>{{cite journal |author=Chang A, Amin A, Gabrielson E, ''et al.'' |title=Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung |journal=Am. J. Surg. Pathol. |volume=36 |issue=10 |pages=1472–6 |year=2012 |month=October |pmid=22982890 |pmc=3444740 |doi=10.1097/PAS.0b013e318260cde7 |url=}}</ref>
*[[Urothelial carcinoma]].<ref name=pmid22982890>{{cite journal |author=Chang A, Amin A, Gabrielson E, ''et al.'' |title=Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung |journal=Am. J. Surg. Pathol. |volume=36 |issue=10 |pages=1472–6 |year=2012 |month=October |pmid=22982890 |pmc=3444740 |doi=10.1097/PAS.0b013e318260cde7 |url=}}</ref>
*[[Invasive breast cancer|Breast carcinoma]] - more sensitive than [[GCDFP-15]].<ref name=pmid24145643>{{Cite journal  | last1 = Miettinen | first1 = M. | last2 = McCue | first2 = PA. | last3 = Sarlomo-Rikala | first3 = M. | last4 = Rys | first4 = J. | last5 = Czapiewski | first5 = P. | last6 = Wazny | first6 = K. | last7 = Langfort | first7 = R. | last8 = Waloszczyk | first8 = P. | last9 = Biernat | first9 = W. | title = GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors. | journal = Am J Surg Pathol | volume = 38 | issue = 1 | pages = 13-22 | month = Jan | year = 2014 | doi = 10.1097/PAS.0b013e3182a0218f | PMID = 24145643 }}</ref>
**[[Lobular breast carcinoma]].<ref name=pmid24061521>{{Cite journal  | last1 = Ellis | first1 = CL. | last2 = Chang | first2 = AG. | last3 = Cimino-Mathews | first3 = A. | last4 = Argani | first4 = P. | last5 = Youssef | first5 = RF. | last6 = Kapur | first6 = P. | last7 = Montgomery | first7 = EA. | last8 = Epstein | first8 = JI. | title = GATA-3 immunohistochemistry in the differential diagnosis of adenocarcinoma of the urinary bladder. | journal = Am J Surg Pathol | volume = 37 | issue = 11 | pages = 1756-60 | month = Nov | year = 2013 | doi = 10.1097/PAS.0b013e31829cdba7 | PMID = 24061521 }}</ref>
*[[Chromophobe renal cell carcinoma]] ~50% of cases.<ref name=pmid24145643/>
*[[Trophoblastic tumours]] +ve.<ref>{{Cite journal  | last1 = Mirkovic | first1 = J. | last2 = Elias | first2 = K. | last3 = Drapkin | first3 = R. | last4 = Barletta | first4 = JA. | last5 = Quade | first5 = B. | last6 = Hirsch | first6 = MS. | title = GATA3 expression in gestational trophoblastic tissues and tumours. | journal = Histopathology | volume = 67 | issue = 5 | pages = 636-44 | month = Nov | year = 2015 | doi = 10.1111/his.12681 | PMID = 25753145 }}</ref> including [[choriocarcinoma]].<ref>{{Cite journal  | last1 = Osman | first1 = H. | last2 = Cheng | first2 = L. | last3 = Ulbright | first3 = TM. | last4 = Idrees | first4 = MT. | title = The utility of CDX2, GATA3, and DOG1 in the diagnosis of testicular neoplasms: an immunohistochemical study of 109 cases. | journal = Hum Pathol | volume = 48 | issue =  | pages = 18-24 | month = Feb | year = 2016 | doi = 10.1016/j.humpath.2015.09.028 | PMID = 26772394 }}</ref>
*Parathyroid - [[parathyroid hyperplasia]], [[parathyroid adenoma]], [[parathyroid carcinoma]].<ref name=pmid25046229>{{Cite journal  | last1 = Ordóñez | first1 = NG. | title = Value of GATA3 immunostaining in the diagnosis of parathyroid tumors. | journal = Appl Immunohistochem Mol Morphol | volume = 22 | issue = 10 | pages = 756-61 | month =  | year =  | doi = 10.1097/PAI.0000000000000007 | PMID = 25046229 }}</ref>
*Salivary gland tumours <ref name=pmid23604756>{{Cite journal  | last1 = Schwartz | first1 = LE. | last2 = Begum | first2 = S. | last3 = Westra | first3 = WH. | last4 = Bishop | first4 = JA. | title = GATA3 immunohistochemical expression in salivary gland neoplasms. | journal = Head Neck Pathol | volume = 7 | issue = 4 | pages = 311-5 | month = Dec | year = 2013 | doi = 10.1007/s12105-013-0442-3 | PMID = 23604756 }}</ref>
*Pheochromocytoma (~70%) vs adrenocortical carcinoma (<10%)<ref name=pmid2837449>{{Cite journal  | last1 = Perrino | first1 = CM. | last2 = Ho | first2 = A. | last3 = Dall | first3 = CP. | last4 = Zynger | first4 = DL. | title = Utility of GATA3 in the differential diagnosis of pheochromocytoma. | journal = Histopathology | volume = 71 | issue = 3 | pages = 475-479 | month = Sep | year = 2017 | doi = 10.1111/his.13229 | PMID = 28374498 }}</ref>
*[[Brenner tumour]]s and [[Walthard cell rest]]s.<ref name=pmid25281026>{{Cite journal  | last1 = Roma | first1 = AA. | last2 = Masand | first2 = RP. | title = Ovarian Brenner tumors and Walthard nests: a histologic and immunohistochemical study. | journal = Hum Pathol | volume = 45 | issue = 12 | pages = 2417-22 | month = Dec | year = 2014 | doi = 10.1016/j.humpath.2014.08.003 | PMID = 25281026 }}</ref>


Negative:
===Images===
*[[Prostate carcinoma]].
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444740/figure/F1/ GATA3 nuclear staining - urothelial carcinoma (nih.gov)].<ref name=pmid22982890/>
*[[Squamous cell carcinoma of the lung]].<ref name=pmid22982890>{{Cite journal  | last1 = Chang | first1 = A. | last2 = Amin | first2 = A. | last3 = Gabrielson | first3 = E. | last4 = Illei | first4 = P. | last5 = Roden | first5 = RB. | last6 = Sharma | first6 = R. | last7 = Epstein | first7 = JI. | title = Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung. | journal = Am J Surg Pathol | volume = 36 | issue = 10 | pages = 1472-6 | month = Oct | year = 2012 | doi = 10.1097/PAS.0b013e318260cde7 | PMID = 22982890 }}</ref>


===Images===
==Negative==
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444740/figure/F1/ GATA3 nuclear staining - urothelial carcinoma (nih.gov)].<ref name=pmid22982890>{{Cite journal  | last1 = Chang | first1 = A. | last2 = Amin | first2 = A. | last3 = Gabrielson | first3 = E. | last4 = Illei | first4 = P. | last5 = Roden | first5 = RB. | last6 = Sharma | first6 = R. | last7 = Epstein | first7 = JI. | title = Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung. | journal = Am J Surg Pathol | volume = 36 | issue = 10 | pages = 1472-6 | month = Oct | year = 2012 | doi = 10.1097/PAS.0b013e318260cde7 | PMID = 22982890 }}</ref>
*[[Prostate carcinoma]] (but beware positivity in benign prostate glands treated with radiotherapy<!--PMID 28316088-->)
*[[Squamous cell carcinoma of the lung]].<ref name=pmid22982890/>


==See also==
==See also==
Mark
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