48,460
edits
(2 intermediate revisions by 2 users not shown) | |||
Line 1: | Line 1: | ||
[[Image:18S00822 axillary metastasis Masson Fontana x40.jpg|thumb|Masson-Fontana staining of metastatic melanoma.]] | |||
'''Fontana-Masson stain''' is a special stain that marks the pigment melanin. It is a type of silver stain.{{fact}} | '''Fontana-Masson stain''' is a special stain that marks the pigment melanin. It is a type of silver stain.{{fact}} | ||
Line 11: | Line 12: | ||
*Stain for melanin. | *Stain for melanin. | ||
**Displays melanin - whether it be in melanocytes, keratinocytes or melanophages. | **Displays melanin - whether it be in melanocytes, keratinocytes or melanophages. | ||
**[[IHC | **[[IHC stains]], i.e. ''Melan A, SOX10 or [[MITF]]'' are preferable for displaying ''melanocytes''. | ||
**Used to differentiate brown pigments (lipofuscin, hemosiderin, melanin).<ref>URL: [http://education.vetmed.vt.edu/curriculum/VM8054/labs/Lab2/Examples/exfontana.htm http://education.vetmed.vt.edu/curriculum/VM8054/labs/Lab2/Examples/exfontana.htm]. Accessed on: 5 May 2010.</ref> | **Used to differentiate brown pigments (lipofuscin, hemosiderin, melanin).<ref>URL: [http://education.vetmed.vt.edu/curriculum/VM8054/labs/Lab2/Examples/exfontana.htm http://education.vetmed.vt.edu/curriculum/VM8054/labs/Lab2/Examples/exfontana.htm]. Accessed on: 5 May 2010.</ref> | ||
**Used to document Minocycline type II drug induced pigment deposition | **Used to document Minocycline type II drug induced pigment deposition | ||
Line 18: | Line 19: | ||
***Idiopathic hypomelanosis will demonstrate ONLY loss of melanin with the Fontana-Masson stain - melanocytes will not be absent with the Melan A stain. | ***Idiopathic hypomelanosis will demonstrate ONLY loss of melanin with the Fontana-Masson stain - melanocytes will not be absent with the Melan A stain. | ||
***Vitiligo will show loss of melanin AND loss of melanocytes with a Melan A stain. | ***Vitiligo will show loss of melanin AND loss of melanocytes with a Melan A stain. | ||
Image: | <!--Image: | ||
*[http://education.vetmed.vt.edu/curriculum/VM8054/labs/Lab2/Examples/exfontana.htm Fontana-Masson stain (vetmed.vt.edu)]. | *[http://education.vetmed.vt.edu/curriculum/VM8054/labs/Lab2/Examples/exfontana.htm Fontana-Masson stain (vetmed.vt.edu)]. | ||
--> | |||
==See also== | ==See also== | ||
*[[Stains]]. | *[[Stains]]. |
edits