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Difference between revisions of "Fontana-Masson stain"
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[[Image:18S00822 axillary metastasis Masson Fontana x40.jpg|thumb|Masson-Fontana staining of metastatic melanoma.]] | |||
'''Fontana-Masson stain''' is a special stain that marks the pigment melanin. It is a type of silver stain.{{fact}} | '''Fontana-Masson stain''' is a special stain that marks the pigment melanin. It is a type of silver stain.{{fact}} | ||
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*Stain for melanin. | *Stain for melanin. | ||
**Displays melanin - whether it be in melanocytes, keratinocytes or melanophages. | **Displays melanin - whether it be in melanocytes, keratinocytes or melanophages. | ||
**IHC stains, i.e. ''Melan A, SOX10 or MITF'' are preferable for displaying ''melanocytes''. | **[[IHC stains]], i.e. ''Melan A, SOX10 or [[MITF]]'' are preferable for displaying ''melanocytes''. | ||
**Used to differentiate brown pigments (lipofuscin, hemosiderin, melanin).<ref>URL: [http://education.vetmed.vt.edu/curriculum/VM8054/labs/Lab2/Examples/exfontana.htm http://education.vetmed.vt.edu/curriculum/VM8054/labs/Lab2/Examples/exfontana.htm]. Accessed on: 5 May 2010.</ref> | **Used to differentiate brown pigments (lipofuscin, hemosiderin, melanin).<ref>URL: [http://education.vetmed.vt.edu/curriculum/VM8054/labs/Lab2/Examples/exfontana.htm http://education.vetmed.vt.edu/curriculum/VM8054/labs/Lab2/Examples/exfontana.htm]. Accessed on: 5 May 2010.</ref> | ||
**Used to document Minocycline type II drug induced pigment deposition | **Used to document Minocycline type II drug induced pigment deposition | ||
***Minocycline pigment, Type II will stain with both the Fontana-Masson stain AND the Perls iron stain.<ref name=pmid19595269>{{cite journal |author=Geria AN, Tajirian AL, Kihiczak G, Schwartz RA |title=Minocycline-induced skin pigmentation: an update |journal=Acta Dermatovenerol Croat |volume=17 |issue=2 |pages=123–6 |year=2009 |pmid=19595269 |doi= |url=}}</ref> | ***Minocycline pigment, Type II will stain with both the Fontana-Masson stain AND the [[Iron stain|Perls iron stain]].<ref name=pmid19595269>{{cite journal |author=Geria AN, Tajirian AL, Kihiczak G, Schwartz RA |title=Minocycline-induced skin pigmentation: an update |journal=Acta Dermatovenerol Croat |volume=17 |issue=2 |pages=123–6 |year=2009 |pmid=19595269 |doi= |url=}}</ref> | ||
**Used in the differential diagnosis of hypomelanosis | **Used in the differential diagnosis of hypomelanosis | ||
***Idiopathic hypomelanosis will demonstrate ONLY loss of melanin with the Fontana-Masson stain - melanocytes will not be absent with the Melan A stain. | ***Idiopathic hypomelanosis will demonstrate ONLY loss of melanin with the Fontana-Masson stain - melanocytes will not be absent with the Melan A stain. | ||
***Vitiligo will show loss of melanin AND loss of melanocytes with a Melan A stain. | ***Vitiligo will show loss of melanin AND loss of melanocytes with a Melan A stain. | ||
Image: | <!--Image: | ||
*[http://education.vetmed.vt.edu/curriculum/VM8054/labs/Lab2/Examples/exfontana.htm Fontana-Masson stain (vetmed.vt.edu)]. | *[http://education.vetmed.vt.edu/curriculum/VM8054/labs/Lab2/Examples/exfontana.htm Fontana-Masson stain (vetmed.vt.edu)]. | ||
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==See also== | ==See also== | ||
*[[Stains]]. | *[[Stains]]. | ||
*[[Minocycline associated thyroid pigmentation]]. | |||
==References== | ==References== | ||