Follicular thyroid adenoma

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Follicular thyroid adenoma, abbreviated FTA, is a benign lesion of the thyroid gland.

General

  • Most common neoplasm of thyroid.[1]
  • Encapusled lesion (surrounded by fibrous capsule).

Gross

  • Thick capsule.

Notes:

  • The entire capsule should be submitted.[2]
    • A good start for most thyroid specimens with a thick capsule is 10 blocks.

Images

Microsopic

Features:

  • Cellular.
  • Thick capsule - key feature.

Negatives.

DDx:

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Left Hemithyroid, Hemithyroidectomy:
- Follicular adenoma.
- Parathyroid gland.
- Five benign lymph nodes (0/5).
- NEGATIVE for evidence of malignancy.

Block letters

LEFT THYROID, SUPERIOR POLE, EXCISION:
- FOLLICULAR ADENOMA, MAXIMAL DIMENSION 5 MM.
- LYMPHOCYTIC THYROIDITIS.
- NODULAR HYPERPLASIA.
- NEGATIVE FOR MALIGNANCY.

Micro

The section shows a well-circumscribed lesion encapsulated by a thick fibrous capsule (~0.4 mm thick).

The lesions consists of microfollicles with a dense appearing colloid. The nuclei have round regular nuclear membranes. Small indistinct nucleoli are seen at high power.

Focally, the lesional cells overlap. However, the chromatin is not cleared. Nuclear grooves are not readily apparent and nuclear pseudoinclusions are not readily identified.

See also

References

  1. Thompson, Lester D. R. (2006). Endocrine Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 51. ISBN 978-0443066856.
  2. SR. 17 January 2011.