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Difference between revisions of "Follicular lymphoma"
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Follicular lymphoma -- low mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Follicular lymphoma. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = Lymph node | | Micro = Lymph node: abundant abnormally-shaped lymphoid follicles with some of the following: non-polarized mantle zone, non-polarized germinal center, loss of tingible body macrophages, sinuses effaced (lost) | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[diffuse large B-cell lymphoma]], other [[small cell lymphomas]], reactive follicular hyperplasia | | LMDDx = [[diffuse large B-cell lymphoma]], other [[small cell lymphomas]], reactive follicular hyperplasia | ||
| Line 11: | Line 11: | ||
| IHC = CD20 +ve, CD10 +ve, BCL-6 +ve, BCL-2 +ve | | IHC = CD20 +ve, CD10 +ve, BCL-6 +ve, BCL-2 +ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = t(14;18)(q32;q21) / IGH-BCL2 | ||
| IF = | | IF = | ||
| Gross = white lesions +/-subtle fine nodularity (fish flesh-like appearance) | | Gross = white lesions +/-subtle fine nodularity (fish flesh-like appearance) | ||
| Line 68: | Line 68: | ||
===Images=== | ===Images=== | ||
<gallery> | |||
Image: Follicular lymphoma -- very low mag.jpg | FL - very low mag. | |||
Image: Follicular lymphoma -- low mag.jpg | FL - low mag. | |||
Image: Follicular lymphoma -- intermed mag.jpg | FL - intermed. mag. | |||
Image: Follicular lymphoma -- high mag.jpg | FL - high mag. | |||
Image: Follicular lymphoma -- very high mag.jpg | FL - very high mag. | |||
</gallery> | |||
<gallery> | <gallery> | ||
Image:Follicular_Lymphoma,_Paratrabecular_Involvement_of_Bone_Marrow_(5691578596).jpg | FL - bone marrow. (WC/euthman) | Image:Follicular_Lymphoma,_Paratrabecular_Involvement_of_Bone_Marrow_(5691578596).jpg | FL - bone marrow. (WC/euthman) | ||
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==IHC== | ==IHC== | ||
Features:<ref name=pmid18359244/> | Features:<ref name=pmid18359244/> | ||
*CD10 +ve. | *[[CD10]] +ve. | ||
*BCL6 +ve. | *BCL6 +ve. | ||
| Line 106: | Line 113: | ||
*CD21 -ve in tumour cells; highlights follicular dendritic cells. | *CD21 -ve in tumour cells; highlights follicular dendritic cells. | ||
*BCL2 +ve<ref name=pmid18359244>{{cite journal |author=Vitolo U, Ferreri AJ, Montoto S |title=Follicular lymphomas |journal=Crit. Rev. Oncol. Hematol. |volume=66 |issue=3 |pages=248–61 |year=2008 |month=June |pmid=18359244 |doi=10.1016/j.critrevonc.2008.01.014 |url=}}</ref> - like many other small cell lymphomas. | *BCL2 +ve<ref name=pmid18359244>{{cite journal |author=Vitolo U, Ferreri AJ, Montoto S |title=Follicular lymphomas |journal=Crit. Rev. Oncol. Hematol. |volume=66 |issue=3 |pages=248–61 |year=2008 |month=June |pmid=18359244 |doi=10.1016/j.critrevonc.2008.01.014 |url=}}</ref> - like many other small cell lymphomas. | ||
**Usually negative in germinal centres | **Usually negative in benign germinal centres. | ||
A panel to work-up: | A panel to work-up: | ||
*BCL2, BCL6, CD3, CD5, CD10, CD20, CD23, cyclin D1. | *BCL2, BCL6, CD3, CD5, CD10, CD20, CD23, cyclin D1. | ||
===Images=== | |||
<gallery> | |||
Image: Follicluar lymphoma - bcl2 -- low mag.jpg | FL - BCL2 - low mag. | |||
Image: Follicular lymphoma - control bcl2 -- low mag.jpg | FL - BCL2 control - low mag. | |||
</gallery> | |||
www: | |||
*[http://www.pathpedia.com/education/eatlas/histopathology/lymph_node/follicular_lymphoma/follicular-lymphoma-%5B16-ln021_cd21%5D.jpeg Follicular lymphoma - CD21 (pathpedia.com)]. | |||
==Molecular== | ==Molecular== | ||