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Difference between revisions of "Follicular dendritic cell sarcoma"
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Follicular dendritic cell sarcoma (view source)
Revision as of 15:50, 10 September 2018
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Follicular dendritic cell sarcoma - alt -- very high mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = [[Micrograph]] showing a follicular dendritic cell sarcoma. The (benign) interspersed lymphocytes are a characteristic finding. [[H&E stain]]. | ||
| Synonyms = follicular dendritic cell tumour, follicular dendritic cell neoplasm | | Synonyms = follicular dendritic cell tumour, follicular dendritic cell neoplasm | ||
| Micro = oval or spindle-shaped cellular & nuclear morphology, variable architecture (sheets, fascicles, whorles, storiform pattern), nuclei with small nucleoli and clear or dispersed chromatin, multinucleated cells, interspersed small lymphocytes, +/-necrosis, +/-marked nuclear atypia, +/-abundant mitoses. | | Micro = oval or spindle-shaped cellular & nuclear morphology, variable architecture (sheets, fascicles, whorles, storiform pattern), nuclei with small nucleoli and clear or dispersed chromatin, multinucleated cells, interspersed small lymphocytes, +/-necrosis, +/-marked nuclear atypia, +/-abundant mitoses. | ||
| Line 9: | Line 9: | ||
| LMDDx = [[histiocytic sarcoma]], [[thymoma]], other [[spindle cell lesions]] | | LMDDx = [[histiocytic sarcoma]], [[thymoma]], other [[spindle cell lesions]] | ||
| Stains = | | Stains = | ||
| IHC = CD21 +ve, CD35 +ve, Ki-M4p +ve, Ki-FDRC1p +ve, vimentin +ve | | IHC = CD21 +ve, CD23 +ve, CD35 +ve, Ki-M4p +ve, Ki-FDRC1p +ve, vimentin +ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
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*Follicular dendritic cell sarcoma/tumour. | *Follicular dendritic cell sarcoma/tumour. | ||
*Dendritic cell sarcoma, not specified otherwise. | *Dendritic cell sarcoma, not specified otherwise. | ||
==Gross== | |||
Features: | |||
*Often a head and neck lesion.{{fact}} | |||
==Microscopic== | ==Microscopic== | ||
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*[[Histiocytic sarcoma]].<ref name=pmid17324277>{{Cite journal | last1 = Alexiev | first1 = BA. | last2 = Sailey | first2 = CJ. | last3 = McClure | first3 = SA. | last4 = Ord | first4 = RA. | last5 = Zhao | first5 = XF. | last6 = Papadimitriou | first6 = JC. | title = Primary histiocytic sarcoma arising in the head and neck with predominant spindle cell component. | journal = Diagn Pathol | volume = 2 | issue = | pages = 7 | month = | year = 2007 | doi = 10.1186/1746-1596-2-7 | PMID = 17324277 | url = http://www.diagnosticpathology.org/content/2/1/7 }}</ref> | *[[Histiocytic sarcoma]].<ref name=pmid17324277>{{Cite journal | last1 = Alexiev | first1 = BA. | last2 = Sailey | first2 = CJ. | last3 = McClure | first3 = SA. | last4 = Ord | first4 = RA. | last5 = Zhao | first5 = XF. | last6 = Papadimitriou | first6 = JC. | title = Primary histiocytic sarcoma arising in the head and neck with predominant spindle cell component. | journal = Diagn Pathol | volume = 2 | issue = | pages = 7 | month = | year = 2007 | doi = 10.1186/1746-1596-2-7 | PMID = 17324277 | url = http://www.diagnosticpathology.org/content/2/1/7 }}</ref> | ||
*[[Thymoma]]. | *[[Thymoma]]. | ||
*[[Spindle cell lesions]]. | *[[Spindle cell lesions]] such as [[sarcomatoid carcinoma]]. | ||
*[[Meningioma]].{{fact}} | |||
===Images=== | ===Images=== | ||
==Related images== | |||
<gallery> | |||
Image: Follicular dendritic cell sarcoma -- very low mag.jpg | FDCS - very low mag. (WC) | |||
Image: Follicular dendritic cell sarcoma -- low mag.jpg | FDCS - low mag. (WC) | |||
Image: Follicular dendritic cell sarcoma - alt -- low mag.jpg | FDCS - low mag. (WC) | |||
Image: Follicular dendritic cell sarcoma -- intermed mag.jpg | FDCS - intermed. mag. (WC) | |||
Image: Follicular dendritic cell sarcoma -- high mag.jpg | FDCS - high mag. (WC) | |||
Image: Follicular dendritic cell sarcoma -- very high mag.jpg | FDCS - very high mag. (WC) | |||
Image: Follicular dendritic cell sarcoma - alt -- very high mag.jpg | FDCS - very high mag. (WC) | |||
</gallery> | |||
====www==== | |||
*[http://www.ajronline.org/doi/full/10.2214/AJR.04.1530 FDCS (ajronline.org)].<ref name=pmid17515347/> | *[http://www.ajronline.org/doi/full/10.2214/AJR.04.1530 FDCS (ajronline.org)].<ref name=pmid17515347/> | ||
*[http://www.npplweb.com/manuscripts/2MXAJX4VWD/0/imgfolder/WJSMRO_2_1_Fig2.jpg FDCS (npplweb.com)].<ref>URL: [http://www.npplweb.com/wjsmro/fulltext/2/1 http://www.npplweb.com/wjsmro/fulltext/2/1]. Accessed on: September 13, 2014.</ref> | *[http://www.npplweb.com/manuscripts/2MXAJX4VWD/0/imgfolder/WJSMRO_2_1_Fig2.jpg FDCS (npplweb.com)].<ref>URL: [http://www.npplweb.com/wjsmro/fulltext/2/1 http://www.npplweb.com/wjsmro/fulltext/2/1]. Accessed on: September 13, 2014.</ref> | ||
*[http://path.upmc.edu/cases/case55/dx.html FDCT - several crappy images (upmc.edu)]. | *[http://path.upmc.edu/cases/case55/dx.html FDCT - several crappy images (upmc.edu)]. | ||
| Line 89: | Line 105: | ||
Note: | Note: | ||
*The interspersed lymphocytes | *The interspersed lymphocytes are B cells.<ref name=pmid21835430>{{Cite journal | last1 = Lorenzi | first1 = L. | last2 = Lonardi | first2 = S. | last3 = Petrilli | first3 = G. | last4 = Tanda | first4 = F. | last5 = Bella | first5 = M. | last6 = Laurino | first6 = L. | last7 = Rossi | first7 = G. | last8 = Facchetti | first8 = F. | title = Folliculocentric B-cell-rich follicular dendritic cells sarcoma: a hitherto unreported morphological variant mimicking lymphoproliferative disorders. | journal = Hum Pathol | volume = 43 | issue = 2 | pages = 209-15 | month = Feb | year = 2012 | doi = 10.1016/j.humpath.2011.02.029 | PMID = 21835430 }}</ref> | ||
===Images=== | |||
<gallery> | |||
Image: Follicular dendritic cell sarcoma - CD23 -- high mag.jpg | FDCS - CD23 - high mag. (WC) | |||
Image: Follicular dendritic cell sarcoma - CD23 -- very high mag.jpg | FDCS - CD23 - very high mag. (WC) | |||
Image: Follicular dendritic cell sarcoma - CD21 -- high mag.jpg | FDCS - CD21 - high mag. (WC) | |||
Image: Follicular dendritic cell sarcoma - CD21 -- very high mag.jpg | FDCS - CD21 - very high mag. (WC) | |||
</gallery> | |||
==See also== | ==See also== | ||