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Florid epithelial hyperplasia (view source)
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'''Florid epithelial hyperplasia''' is a common benign [[breast pathology]] finding that is associated with a mild increased risk of [[breast cancer]]. | |||
It is also known as '''florid epithelial hyperplasia of the usual type''' (abbreviated '''FEHUT''') and '''usual ductal hyperplasia''' (abbreviated '''UDH'''). | |||
Confusingly, it may be referred to as ''epithelial hyperplasia'', term that is best avoided, as it could lead to confusion with ''[[mild epithelial hyperplasia]]''. | |||
==General== | |||
*Mild increased risk of malignancy ~ 1.5-2x.<ref>{{Ref PCPBoD8|542}}</ref> | |||
*Has to be separated from ''[[mild epithelial hyperplasia]]''. | |||
Note: | |||
*''Moderate epithelial hyperplasia'' redirects to this section. | |||
**It is generally not separated from FEH, as the prognosis is thought to be the same. | |||
==Microscopic== | |||
Features:<ref>{{Ref BP|159-160}}</ref> | |||
*Breast glands with ''more than'' four cell layers above the basement membrane - '''key feature'''. | |||
*Irregular cell spacing; streaming. | |||
*Slit-like lumina, esp. at the periphery of the duct. | |||
*No [[DCIS]]-like architecture (not cribriform, not papillary, not micropapillary, not solid). | |||
*No nuclear atypia - usually no [[nucleoli]]. | |||
Memory device ''CLEAN'': | |||
*'''C'''ell spacing is irregular, '''L'''umina are slit-like, '''E'''xtent is less than 2 mm or 2 ducts, '''A'''rchitecture ''not'' DCIS-like, '''N'''uclear atypia ''not'' present. | |||
DDx: | |||
*[[Mild epithelial hyperplasia]]. | |||
*[[Atypical ductal hyperplasia]]. | |||
*Cribriform [[ductal carcinoma in situ]] | |||
==Sign out== | |||
<pre> | |||
A. Right Breast (570 grams), Reduction Mammoplasty: | |||
- Benign breast tissue with proliferative fibrocystic changes. | |||
- Benign skin. | |||
B. Left Breast (580 grams), Reduction Mammoplasty: | |||
- Breast tissue and skin within normal limits. | |||
</pre> | |||
Note: | |||
*"Proliferative fibrocystic changes" = UDH + [[fibrocystic changes]]. | |||
==See also== | |||
*[[Breast pathology]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Breast pathology]] | |||