Fibromatoses

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Micrograph showing a palmar fibromatosis. H&E stain.

Fibromatoses are a group of benign stromal lesions that may or may not be associated with syndromes.

Plantar fibromatosis redirects here.

Syndromes associated with fibromatoses

Types

Superficial

Deep

Gross

  • Firm.
  • Infiltrative borders.

Image:

Microscopic

Features:

  • Bland spindle cells - typically in fascicles.
    • Pale eosinophilic cytoplasm.[3]
    • Nucleus may be ovoid.[4]
  • Small thin blood vessels that are parallel to one another.
    • Nuclei of blood vessels are typically darker staining than those of the lesion.

DDx:

Images:

IHC

  • Beta-catenin +ve -- nuclear stain.
  • CD117 -ve.
  • CD34 -ve.[5]

Image:

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Deep

SOFT TISSUE LESION, LEFT SHOULDER, CORE BIOPSY:
- FIBROMATOSIS, SEE COMMENT.

COMMENT:
The lesion was evaluated with immunostains:
Positive: vimentin, SMA (rare), beta-catenin.
Negative: pankeratin, S-100, desmin, CD34 (stains vessels).

Plantar

Left Foot, Plantar Fascia, Fasciectomy:
	- Plantar fibromatosis.

Micro

The sections show a lesion with bland spindle cells. There is no apparent nuclear atypia. Mitotic figures are not identified. No myxoid areas are apparent. No necrosis is identified.

See also

References

  1. Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1092. ISBN 978-1416031215.
  2. Mozena JD, Hansen EK, Jones PC (March 2022). "Radiotherapy for Plantar Fibromas (Ledderhose Disease)". J Am Podiatr Med Assoc 112 (1). doi:10.7547/19-008. PMID 35324461.
  3. URL: http://www.histopathology-india.net/Fibromatosis.htm. Accessed on: 18 September 2012.
  4. 4.0 4.1 4.2 Murphey, MD.; Ruble, CM.; Tyszko, SM.; Zbojniewicz, AM.; Potter, BK.; Miettinen, M. (Nov 2009). "From the archives of the AFIP: musculoskeletal fibromatoses: radiologic-pathologic correlation.". Radiographics 29 (7): 2143-73. doi:10.1148/rg.297095138. PMID 19926768.
  5. Li Destri, G.; Ferraro, MJ.; Calabrini, M.; Pennisi, M.; Magro, G. (2014). "Desmoid-type fibromatosis of the mesentery: report of a sporadic case with emphasis on differential diagnostic problems.". Case Rep Med 2014: 850180. doi:10.1155/2014/850180. PMID 25349618.

External links