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Difference between revisions of "Fibromatoses"
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'''Fibromatoses''' are a group of benign stromal lesions that | [[Image:Palmar fibromatosis - alt -- high mag.jpg|thumb|right|Micrograph showing a [[palmar fibromatosis]]. [[H&E stain]].]] | ||
'''Fibromatoses''' are a group of benign stromal lesions that may or may not be associated with [[syndromes]]. | |||
==Syndromes associated with fibromatoses== | ==Syndromes associated with fibromatoses== | ||
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Features: | Features: | ||
*Bland spindle cells - typically in fascicles. | *Bland spindle cells - typically in fascicles. | ||
**Pale eosinophilic cytoplasm.<ref>URL: [http://www.histopathology-india.net/Fibromatosis.htm http://www.histopathology-india.net/Fibromatosis.htm]. Accessed on: 18 September 2012.</ref> | |||
**Nucleus may be ovoid.<ref name=pmid19926768/> | |||
*Small thin blood vessels that are parallel to one another. | *Small thin blood vessels that are parallel to one another. | ||
**Nuclei of [[blood vessel]]s are typically darker staining than those of the lesion. | **Nuclei of [[blood vessel]]s are typically darker staining than those of the lesion. | ||
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*[[Dermatofibroma]]. | *[[Dermatofibroma]]. | ||
*[[GIST]]. | *[[GIST]]. | ||
*[[Desmoplastic fibroblastoma]] - esp. shoulder region. | |||
Images: | |||
*[http://www.sarcomaimages.com/index.php?v=Plantar-Fibromatosis Plantar fibromatosis (sarcomaimages.com)]. | *[http://www.sarcomaimages.com/index.php?v=Plantar-Fibromatosis Plantar fibromatosis (sarcomaimages.com)]. | ||
*[http://www.flickr.com/photos/lunarcaustic/5333412517/in/photostream/ Mesenteric fibromatosis (flickr.com)]. | *[http://www.flickr.com/photos/lunarcaustic/5333412517/in/photostream/ Mesenteric fibromatosis (flickr.com)]. | ||
*[http://radiographics.rsna.org/content/29/7/2143/F12.expansion.html Plantar fibromatosis (rsna.org)].<ref name=pmid19926768/> | |||
*[http://radiographics.rsna.org/content/29/7/2143/F17.expansion.html Plantar fibromatosis (rsna.org)].<ref name=pmid19926768>{{Cite journal | last1 = Murphey | first1 = MD. | last2 = Ruble | first2 = CM. | last3 = Tyszko | first3 = SM. | last4 = Zbojniewicz | first4 = AM. | last5 = Potter | first5 = BK. | last6 = Miettinen | first6 = M. | title = From the archives of the AFIP: musculoskeletal fibromatoses: radiologic-pathologic correlation. | journal = Radiographics | volume = 29 | issue = 7 | pages = 2143-73 | month = Nov | year = 2009 | doi = 10.1148/rg.297095138 | PMID = 19926768 }}</ref> | |||
==IHC== | ==IHC== | ||
*Beta-catenin +ve. | *Beta-catenin +ve -- nuclear stain. | ||
*CD117 -ve. | *CD117 -ve. | ||
*CD34 -ve.<ref name=pmid25349618>{{Cite journal | last1 = Li Destri | first1 = G. | last2 = Ferraro | first2 = MJ. | last3 = Calabrini | first3 = M. | last4 = Pennisi | first4 = M. | last5 = Magro | first5 = G. | title = Desmoid-type fibromatosis of the mesentery: report of a sporadic case with emphasis on differential diagnostic problems. | journal = Case Rep Med | volume = 2014 | issue = | pages = 850180 | month = | year = 2014 | doi = 10.1155/2014/850180 | PMID = 25349618 }}</ref> | |||
Image: | |||
*[http://pathinfo.wikia.com/wiki/File:Beta-catenin.fibromatosis.1.jpg Fibromatosis (wikia.com)]. | |||
==Sign out== | |||
<pre> | |||
SOFT TISSUE LESION, LEFT SHOULDER, CORE BIOPSY: | |||
- FIBROMATOSIS, SEE COMMENT. | |||
COMMENT: | |||
The lesion was evaluated with immunostains: | |||
Positive: vimentin, SMA (rare), beta-catenin. | |||
Negative: pankeratin, S-100, desmin, CD34 (stains vessels). | |||
</pre> | |||
===Micro=== | |||
The sections show a lesion with bland spindle cells. There is no apparent nuclear atypia. Mitotic figures are not identified. No myxoid areas are apparent. No necrosis is identified. | |||
==See also== | ==See also== | ||
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[[Category:Weird stuff]] | [[Category:Weird stuff]] | ||
[[Category:Soft tissue pathology]] | |||