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Difference between revisions of "Fibroblastic/myofibroblastic tumours"
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Fibroblastic/myofibroblastic tumours (view source)
Revision as of 21:08, 30 January 2013
, 21:08, 30 January 2013→Desmoplastic fibroblastoma
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===Microscopic=== | ===Microscopic=== | ||
Features:<ref | Features:<ref name=pmid9670823/><ref name=Ref_Sternberg4_161>{{Ref Sternberg4|161}}</ref> | ||
*Spindle cells ''or'' stellate cells without nuclear atypia. | |||
*Acellular stroma with abundant collagen - '''key feature'''. | *Acellular stroma with abundant collagen - '''key feature'''. | ||
* | *+/-Myxoid areas. | ||
*+/-Rare mitoses. | |||
DDx: | DDx: | ||
| Line 271: | Line 273: | ||
===IHC=== | ===IHC=== | ||
Features:<ref name=pmid9670823>{{Cite journal | last1 = Miettinen | first1 = M. | last2 = Fetsch | first2 = JF. | title = Collagenous fibroma (desmoplastic fibroblastoma): a clinicopathologic analysis of 63 cases of a distinctive soft tissue lesion with stellate-shaped fibroblasts. | journal = Hum Pathol | volume = 29 | issue = 7 | pages = 676-82 | month = Jul | year = 1998 | doi = | PMID = 9670823 }}</ref> | |||
*Beta-catenin -ve.<ref name=pmid18544056>{{Cite journal | last1 = Takahara | first1 = M. | last2 = Ichikawa | first2 = R. | last3 = Oda | first3 = Y. | last4 = Uchi | first4 = H. | last5 = Takeuchi | first5 = S. | last6 = Moroi | first6 = Y. | last7 = Kiryu | first7 = H. | last8 = Furue | first8 = M. | title = Desmoplastic fibroblastoma: a case presenting as a protruding nodule in the dermis. | journal = J Cutan Pathol | volume = 35 Suppl 1 | issue = | pages = 70-3 | month = Oct | year = 2008 | doi = 10.1111/j.1600-0560.2007.00964.x | PMID = 18544056 }} | *Beta-catenin -ve.<ref name=pmid18544056>{{Cite journal | last1 = Takahara | first1 = M. | last2 = Ichikawa | first2 = R. | last3 = Oda | first3 = Y. | last4 = Uchi | first4 = H. | last5 = Takeuchi | first5 = S. | last6 = Moroi | first6 = Y. | last7 = Kiryu | first7 = H. | last8 = Furue | first8 = M. | title = Desmoplastic fibroblastoma: a case presenting as a protruding nodule in the dermis. | journal = J Cutan Pathol | volume = 35 Suppl 1 | issue = | pages = 70-3 | month = Oct | year = 2008 | doi = 10.1111/j.1600-0560.2007.00964.x | PMID = 18544056 }} | ||
</ref> | </ref> | ||
**+ve in [[desmoid-type fibromatosis]]. | **+ve in [[desmoid-type fibromatosis]]. | ||
*Desmin -ve. | |||
*S-100 -ve. | |||
*CD34 -ve. | |||
*MSA +ve (focal). | |||
*alpha-SMA +ve (focal). | |||
===Molecular=== | ===Molecular=== | ||