Difference between revisions of "Fetal autopsy"

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====Adrenal fetal fat pattern====
====Adrenal fetal fat pattern====
*Can be access with ''oil red O'' staining.
*Can be assessed with ''oil red O'' staining.


The pattern of adrenal fat is informative about duration of stress prior to (intrauterine) demise:<ref>{{cite journal |author=Becker MJ, Becker AE |title=Fat distribution in the adrenal cortex as an indication of the mode of intrauterine death |journal=Hum. Pathol. |volume=7 |issue=5 |pages=495–504 |year=1976 |month=September |pmid=964978 |doi= |url=}}</ref>
The pattern of adrenal fat is informative about duration of stress prior to (intrauterine) demise:<ref>{{cite journal |author=Becker MJ, Becker AE |title=Fat distribution in the adrenal cortex as an indication of the mode of intrauterine death |journal=Hum. Pathol. |volume=7 |issue=5 |pages=495–504 |year=1976 |month=September |pmid=964978 |doi= |url=}}</ref>
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Additional ref.: [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1545415/pdf/archdisch00800-0007.pdf http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1545415/pdf/archdisch00800-0007.pdf].
Additional ref.: [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1545415/pdf/archdisch00800-0007.pdf http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1545415/pdf/archdisch00800-0007.pdf].
===Kidney===
===Kidney===
*Cortex regresses.
*Cortex regresses.
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===Gross===
===Gross===
Features:
*Autoamputation of appendages and body wall defects +/- anomalies of internal organs.
*Autoamputation of appendages and body wall defects +/- anomalies of internal organs.
*Fibrous bands - '''key feature''' for ''amniotic band syndrome''.  
*+/-Fibrous bands (seen cases labelled ''amniotic band syndrome'').  


Images:
Images:
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==Developmental stuff==
==Developmental stuff==
===Chiari malformations===
===Neural tube defects===
Numbered from least severe to most severe:
*Anencephaly - no brain, top of head missing.
*Chiari type I - tonsils herniated<ref>URL: [http://rarediseases.info.nih.gov/GARD/Disease.aspx?diseaseID=9230 http://rarediseases.info.nih.gov/GARD/Disease.aspx?diseaseID=9230]. Accessed on: 6 May 2011.</ref> (radiologic definition: 4-6 mm below the plane of the foramen magnum).
*Spina bifida.
**Associated with: sudden death, sleep apnea, cerebellar ataxia.
**Spina bifida cystica.
*Chiari type II - often assoc. with hydrocephaly at birth.
***Meningocele - less severe, herniation of only the membrane.
*Chiari type III - cerebellum + brain stem herniate through foramen magnum +/- encephalocele.<ref>URL: [http://www.ninds.nih.gov/disorders/chiari/detail_chiari.htm http://www.ninds.nih.gov/disorders/chiari/detail_chiari.htm]. Accessed on: 6 May 2011.</ref>
***Myelomeningocele - more sever, herniation of membranes and cord.
*Chiari type IV - cerebellar hypoplasia or no cerebellum.
**Spina bifida occulta.
 
===Chiari malformation===
{{Main|Chiari malformation}}


===Dandy-Walker syndrome===
===Dandy-Walker syndrome===
1

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