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Difference between revisions of "Female adnexal tumour of probable Wolffian origin"
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Female adnexal tumour of probable Wolffian origin (view source)
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Female adnexal tumour of probable Wolffian origin - very high mag.jpg | |||
| Width = | |||
| Caption = FATWO. [[H&E stain]]. | |||
| Micro = | |||
| Subtypes = | |||
| LMDDx = | |||
| Stains = | |||
| IHC = vimentin +ve, AE1/AE3 +ve, CAM5.2 +ve, AR +ve (~80% of cases) | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = adnexa ([[ovary]]) | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = very rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = usu. benign | |||
| Other = | |||
| ClinDDx = | |||
}} | |||
'''Female adnexal tumour of probable Wolffian origin''', abbreviated '''FATWO''', is a rare usually benign tumour. | |||
It is also known as '''Wolffian adnexal tumour''', abbreviated '''WAT'''. | |||
==General== | |||
*Super rare.<ref name=pmid22611973>{{Cite journal | last1 = Tianmin | first1 = X. | last2 = Weiqim | first2 = C. | last3 = Mianhua | first3 = C. | last4 = Xiaocui | first4 = L. | last5 = Hongwen | first5 = G. | last6 = Min | first6 = Y. | title = Tumor of the mesosalpinx: case report of a female adnexal tumor of probable Wolffian origin. | journal = Eur J Gynaecol Oncol | volume = 33 | issue = 2 | pages = 233-5 | month = | year = 2012 | doi = | PMID = 22611973 }}</ref> | |||
*Usually benign. | |||
**May be malignant.<ref name=pmid21542539>{{Cite journal | last1 = Heller | first1 = DS. | last2 = Kadire | first2 = B. | last3 = Cracchiolo | first3 = B. | title = Malignant female adnexal tumor of probable Wolffian origin: a case report. | journal = J Reprod Med | volume = 56 | issue = 3-4 | pages = 175-7 | month = | year = | doi = | PMID = 21542539 }}</ref> | |||
==Gross== | |||
Adnexal location - as the name suggests:<ref name=pmid10414506/> | |||
*Broad ligament of ovary. | |||
*Mesosalpinx. | |||
*Ovarian hilus - less common. | |||
==Microscopic== | |||
Features:<ref name=pmid10414506/> | |||
*Variable architecture: | |||
**Tubular or glandular. | |||
**Solid - spindle cells. | |||
**Multicystic. | |||
DDx: | |||
*[[Brenner tumour]]. | |||
===Images=== | |||
<gallery> | |||
Image: Female adnexal tumour of probable Wolffian origin - intermed mag.jpg | FATWO - intermed. mag. | |||
Image: Female adnexal tumour of probable Wolffian origin - high mag.jpg | FATWO - high mag. | |||
Image: Female adnexal tumour of probable Wolffian origin - very high mag.jpg | FATWO - very high mag. | |||
</gallery> | |||
==IHC== | |||
Features:<ref name=pmid10414506>{{Cite journal | last1 = Devouassoux-Shisheboran | first1 = M. | last2 = Silver | first2 = SA. | last3 = Tavassoli | first3 = FA. | title = Wolffian adnexal tumor, so-called female adnexal tumor of probable Wolffian origin (FATWO): immunohistochemical evidence in support of a Wolffian origin. | journal = Hum Pathol | volume = 30 | issue = 7 | pages = 856-63 | month = Jul | year = 1999 | doi = | PMID = 10414506 }}</ref> | |||
*Vimentin +ve. | |||
*AE1/AE3 +ve. | |||
*CAM5.2 +ve. | |||
*CK7 +ve -- focal, sometimes -ve. | |||
*AR +ve ~80% of cases. | |||
*Inhibin +ve ~70% of cases. | |||
Others:<ref name=pmid10414506/> | |||
*CK20 -ve. | |||
*mCEA -ve. | |||
==See also== | |||
*[[Gynecologic pathology]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Gynecologic pathology]] | |||