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The '''eye''' is rarely seen by pathologists.  Typically, they go to neuropathologists, as the eye is really part of the brain.  The article also covers lesions found around the eye.  The lacrimal gland is covered in the ''[[lacrimal gland]]'' article.   
[[Image:Gray888.png|thumb|300px|Illustration of the eye. (Gray's Anatomy/WC)]]
[[Image:Optic nerve head and retina -- low mag.jpg|thumb|300px|Micrograph showing the optic nerve head and retina. [[H&E stain]]. (WC)]]
The '''eye''' is rarely seen by pathologists.  Typically, they go to neuropathologists, as the eye is really part of the brain.  The article also covers many of the lesions found around the eye.  The lacrimal gland is covered in the ''[[lacrimal gland]]'' article.  Eyelid lesions are covered in the ''[[eyelid]]'' article.   


An introduction to neuropathology is in the ''[[neuropathology]]'' article.
An introduction to neuropathology is in the ''[[neuropathology]]'' article.
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*Surrounded by CSF.
*Surrounded by CSF.
*Covered by dura.
*Covered by dura.
====Images====
<gallery>
Image: Optic nerve -- very low mag.jpg | CN II - very low mag. (WC)
Image: Optic nerve -- low mag.jpg | CN II - low mag. (WC)
Image: Optic nerve -- intermed mag.jpg | CN II - intermed. mag. (WC)
Image: Optic nerve -- high mag.jpg | CN II - high mag. (WC)
</gallery>


===Inside to outside===
===Inside to outside===
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#Choroid.
#Choroid.
#Sclera.
#Sclera.
====Image====
<gallery>
Image:Optic nerve head and retina -- low mag.jpg| Optic nerve head and retina - low mag. (WC)
</gallery>


===Anterior angle===
===Anterior angle===
*Angle between cornea and iris.
*Angle between cornea and iris.
===Canthi===
The canthi are where the upper and lower eyelids meet:
*Medial canthus.
*Lateral canthus.
Note:
*The most common malignant canthus lesion is [[basal cell carcinoma]].<ref>URL: [https://iovs.arvojournals.org/article.aspx?articleid=2372910 https://iovs.arvojournals.org/article.aspx?articleid=2372910]. Accessed on: 2022 Nov 17.</ref>


=Histology=
=Histology=
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===Retina===
===Retina===
[[Image:Retina -- very high mag.jpg|thumb|right|300px|Retina. (WC)]]
Simplified structure - eosinophilic material separating:
Simplified structure - eosinophilic material separating:
#Intermediate size, round, pale-staining nuclei (ganglion cells).
#Intermediate size, round, pale-staining nuclei (ganglion cells).
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<gallery>
<gallery>
Image:Gray881.png | Retina - schematic. (WC/Gray's)
Image:Gray881.png | Retina - schematic. (WC/Gray's)
Image: Optic nerve head and retina -- low mag.jpg | Optic nerve & retina - low mag. (WC)
Image: Retina -- intermed mag.jpg | Retina - intermed. mag. (WC)
Image: Retina -- high mag.jpg | Retina - high mag. (WC)
</gallery>
</gallery>
www:
www:
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==Pterygium==
==Pterygium==
*[[AKA]] surfer eye.
*[[AKA]] surfer eye.
===General===
{{Main|Pterygium}}
*Pronounced: "tuh-rij-ee-uhm".<ref>URL: [http://dictionary.reference.com/browse/pterygium http://dictionary.reference.com/browse/pterygium]. Accessed on: 20 October 2011</ref>
*Conjunctiva lesion that covers part of the sclera.
**Sclera = white part of the eye.<ref>URL: [http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002006/ http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002006/]. Accessed on: 20 October 2011.</ref>
*Benign.
*Due to ultraviolet light exposure, i.e. sunlight.<ref name=pmid2695353>{{Cite journal  | last1 = Hill | first1 = JC. | last2 = Maske | first2 = R. | title = Pathogenesis of pterygium. | journal = Eye (Lond) | volume = 3 ( Pt 2) | issue =  | pages = 218-26 | month =  | year = 1989 | doi = 10.1038/eye.1989.31 | PMID = 2695353 | URL = http://www.nature.com/eye/journal/v3/n2/abs/eye198931a.html }}</ref>
 
===Gross===
*Medial aspect of eye - covers sclera (white part) and part of the iris (coloured part).
 
Image:
*[http://trialx.com/curebyte/2011/05/31/what-does-pterygium-look-like/ Pterygium - gross (trialx.com)].
 
===Microscopic===
Features:<ref name=pmid2695353>{{Cite journal  | last1 = Hill | first1 = JC. | last2 = Maske | first2 = R. | title = Pathogenesis of pterygium. | journal = Eye (Lond) | volume = 3 ( Pt 2) | issue =  | pages = 218-26 | month =  | year = 1989 | doi = 10.1038/eye.1989.31 | PMID = 2695353 | URL = http://www.nature.com/eye/journal/v3/n2/abs/eye198931a.html }}</ref>
*Hyaline material beneath epithelium.
*Elastic fibres beneath the hyaline material.
*+/-Inflammation.
*[[Solar elastosis]].<ref name=uic_edu>URL: [http://www.uic.edu/depts/mcpt/eyepath/specco4.htm http://www.uic.edu/depts/mcpt/eyepath/specco4.htm]. Accessed on: 25 October 2011.</ref>
**Dense gray/light brown acellular material.
*Dilated vessels.<ref name=uic_edu>URL: [http://www.uic.edu/depts/mcpt/eyepath/specco4.htm http://www.uic.edu/depts/mcpt/eyepath/specco4.htm]. Accessed on: 25 October 2011.</ref>
 
DDx:
*Squamous dysplasia.
*[[Squamous cell carcinoma]].<ref name=pmid427069>{{Cite journal  | last1 = Clear | first1 = AS. | last2 = Chirambo | first2 = MC. | last3 = Hutt | first3 = MS. | title = Solar keratosis, pterygium, and squamous cell carcinoma of the conjunctiva in Malawi. | journal = Br J Ophthalmol | volume = 63 | issue = 2 | pages = 102-9 | month = Feb | year = 1979 | doi =  | PMID = 427069 | PMC = 1043407 }}</ref>
 
====Images====
www:
*[http://www.uic.edu/depts/mcpt/eyepath/specco4.htm Pterygium (uic.edu)].
<gallery>
Image:Pterygium_-_intermed_mag.jpg | Pterygium - intermed. mag. (WC/Nephron)
Image:Pterygium_-_high_mag.jpg | Pterygium - high mag. (WC/Nephron)
</gallery>
===Sign out===
====Right eye====
<pre>
CONJUNCTIVA ("PTERYGIUM"), RIGHT EYE, EXCISION:
- CONJUNCTIVAL MUCOSA WITH SOLAR ELASTOSIS AND DILATED SUPERFICIAL BLOOD VESSELS -- CONSISTENT WITH PTERYGIUM.
- NEGATIVE FOR DYSPLASIA.
</pre>
 
=====Alternates=====
<pre>
CONJUNCTIVA ("PTERYGIUM"), RIGHT, EXCISION:
- CONJUNCTIVAL MUCOSA WITH STROMAL ACTINIC CHANGES -- CONSISTENT WITH PTERYGIUM.
</pre>
 
<pre>
CONJUNCTIVA ("PTERYGIUM"), RIGHT, EXCISION:
- CONJUNCTIVAL MUCOSA WITH STROMAL ACTINIC CHANGES -- CONSISTENT WITH PTERYGIUM.
- NEGATIVE FOR DYSPLASIA.
</pre>
====Left eye====
<pre>
CONJUNCTIVA ("PTERYGIUM"), LEFT EYE, EXCISION:
- CONJUNCTIVAL MUCOSA WITH SOLAR ELASTOSIS AND DILATED SUPERFICIAL BLOOD VESSELS -- CONSISTENT WITH PTERYGIUM.
- NEGATIVE FOR DYSPLASIA.
</pre>


==Eccrine hidrocystoma==
==Eccrine hidrocystoma==
*Occasionally spelled ''eccrine hydrocystoma''.<ref name=pmid10065300/>
*Occasionally spelled ''eccrine hydrocystoma''.<ref name=pmid10065300/>
===General===
{{Main|Eccrine hidrocystoma}}
*Benign.
*Eyelid lesion.
 
Clinical DDx:<ref name=pmid10065300/>
*Cystic [[BCC]].
 
===Microsopic===
Features:<ref name=pmid15205675>{{Cite journal  | last1 = Singh | first1 = AD. | last2 = McCloskey | first2 = L. | last3 = Parsons | first3 = MA. | last4 = Slater | first4 = DN. | title = Eccrine hidrocystoma of the eyelid. | journal = Eye (Lond) | volume = 19 | issue = 1 | pages = 77-9 | month = Jan | year = 2005 | doi = 10.1038/sj.eye.6701404 | PMID = 15205675 }}</ref><ref>{{Ref Derm|314}}</ref>
*Cyst lined by a bland bilayer.
**Inner lining cells have:
***Small, round nuclei - usu. basal.
***Moderate pale/greyish cytoplasm.
***No apocrine snouts - flat surface.
**Outer lining cells - spindled.
***May be difficult to see.
 
Note:
*According to the CMAJ, it has the histology of an [[epidermal inclusion cyst]].<ref name=pmid10065300>{{Cite journal  | last1 = Adams | first1 = SP. | title = Dermacase. Eccrine hydrocystoma. | journal = Can Fam Physician | volume = 45 | issue =  | pages = 297, 306 | month = Feb | year = 1999 | doi =  | PMID = 10065300 |PMC = 2328272 }}</ref>
 
DDx:
*[[Apocrine hidrocystoma]] - have apocrine snouts; surface is ''not'' flat.
*Cystadenoma - has epithelial proliferation.
 
====Image====
<gallery>
Image:SkinTumors-P7110453.JPG | Apocrine hidrocystoma (AH). AH looks similar to ''eccrine hidrocystoma''. (WC)
</gallery>
www:
*[http://www.nature.com/eye/journal/v19/n1/fig_tab/6701404f1.html Eccrine hidrocystoma (nature.com)].
*[http://www.dermnet.org.nz/pathology/apocrine-hidrocystoma-path.html Apocrine hidrocystoma (dermnet.org)].
*[http://www.flickr.com/photos/42574434@N03/9519309216 Apocrine hidrocystoma (flickr.com)].
 
===Sign out===
<pre>
SKIN LESION, ADJACENT TO RIGHT EYELID, EXCISION:
- ECCRINE HIDROCYSTOMA.
</pre>
 
====Micro====
The sections show hair bearing skin with a cyst lined by a bland bilayered epithelium.  The predominant lining cell has moderate pale grey cytoplasm and a small round nucleus. 
 
The lesion is excised in the plane of section.


==Chalazion==
==Chalazion==
===General===
{{Main|Chalazion}}
*Benign eye thingy that arises from the special sebaceous gland associated with the eyelid (Meibomian gland).
*Usually diagnosed based on clinical appearance - accuracy ~94% in one series.<ref name=pmid14762403>{{Cite journal  | last1 = Ozdal | first1 = PC. | last2 = Codère | first2 = F. | last3 = Callejo | first3 = S. | last4 = Caissie | first4 = AL. | last5 = Burnier | first5 = MN. | title = Accuracy of the clinical diagnosis of chalazion. | journal = Eye (Lond) | volume = 18 | issue = 2 | pages = 135-8 | month = Feb | year = 2004 | doi = 10.1038/sj.eye.6700603 | PMID = 14762403 | url = http://www.nature.com/eye/journal/v18/n2/full/6700603a.html }}</ref>
 
===Gross===
*Focal eyelid swelling - typically upper eyelid.
 
DDx (clinical):<ref name=pmid14762403/>
*[[Sebaceous cell carcinoma]].
*[[Basal cell carcinoma]].
 
====Images====
<gallery>
Image:Gradowka.jpg | Chalazion (WC)
</gallery>
www:
*[http://eyewiki.aao.org/File:Chalazion2_01242005.jpg Chalazion (eyewiki.aao.org)].
 
===Microscopic===
Features:
*Lipogranulomas - '''key feature'''.<ref name=pmid14762403/>
**[[Granuloma]]tous inflammation around clear spaces (lipid).<ref name=pmid15029054>{{Cite journal  | last1 = D'hermies | first1 = F. | last2 = Fayet | first2 = B. | last3 = Meyer | first3 = A. | last4 = Morel | first4 = X. | last5 = Halhal | first5 = M. | last6 = Elmaleh | first6 = C. | last7 = Azan | first7 = F. | last8 = Behar-Cohen | first8 = F. | last9 = Renard | first9 = G. | title = [Chalazion mimicking an eyelid tumor]. | journal = J Fr Ophtalmol | volume = 27 | issue = 2 | pages = 202-5 | month = Feb | year = 2004 | doi =  | PMID = 15029054 }}</ref>
**Multinucleated giant cells - common.
***+/-[[Touton giant cell]]s.<ref>URL: [http://emedicine.medscape.com/article/1212709-workup http://emedicine.medscape.com/article/1212709-workup]. Accessed on: 9 February 2012.</ref>
*Plasma cells - abundant - '''important'''.
 
====Images====
<gallery>
Image:Chalazion_of_the_Eyelid.jpg | Chalazion. (WC/euthman)
</gallery>
www:
*[http://www.nature.com/eye/journal/v18/n2/fig_tab/6700603f1.html#figure-title Chalazion and its clinical DDx (nature.com)].<ref name=pmid14762403/>
*[http://www.surgical-pathology.com/chala.JPG Chalazion (surgical-pathology.com)].<ref>URL: [http://www.surgical-pathology.com/chalazion.htm http://www.surgical-pathology.com/chalazion.htm]. Accessed on: 24 January 2012.</ref>
*[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=20080802170139555 Chalazion (surgicalpathologyatlas.com)].
 
===Sign out===
<pre>
EYELID LESION, RIGHT UPPER, BIOPSY:
- LIPOGRANULOMAS.
- LYMPHOPLASMACYTIC RICH INFLAMMATORY INFILTRATE.
- GRANULATION TISSUE.
- REACTIVE SQUAMOUS MUCOSA.
 
COMMENT:
The findings are consistent with a chalazion.
 
Special stains (ZN, PASD, GMS) did not demonstrate microorganisms.
</pre>
 
====Alternate====
<pre>
SKIN LESION, LEFT LOWER EYELID, PUNCH BIOPSY:
- LIPOGRANULOMAS WITH GIANT CELLS AND A LYMPHOPLASMACYTIC RICH INFLAMMATORY
  INFILTRATE -- CONSISTENT WITH CHALAZION.
- GRANULATION TISSUE.
- NEGATIVE FOR MALIGNANCY.
</pre>
 
====Micro====
The sections show a reactive squamous mucosa with palisading granulomas that surround clear spaces (lipid). This is accompanied by a lymphoplasmacytic rich inflammatory infiltrate. Granulation tissue is present. Rare multinucleated giant cells are identified. Neutrophils are numerous and seen in association with the histiocytes.
 
No significant nuclear atypia is apparent.


==Retinal hemorrhage==
==Retinal hemorrhage==
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Note:
Note:
*''Blepharochalasis'' may be the label given when an eyelid tuck is done.
*The term may be abused; it may be used when an eyelid tuck is done for other reasons.{{fact}}


===Microscopic===
===Microscopic===
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- SUBEPITHELIAL TISSUE WITH MILD EDEMA.
- SUBEPITHELIAL TISSUE WITH MILD EDEMA.
- SOLAR ELASTOSIS.
- SOLAR ELASTOSIS.
- NEGATIVE FOR MALIGNANCY.
</pre>
====Lower eyelids in an older individual labelled blepharochalasis====
<pre>
A. EYELID, LEFT LOWER, BLEPHAROPLASTY:
- BENIGN SKIN WITH MILD SOLAR ELASTOSIS.
- BENIGN SKELETAL MUSCLE AND ADIPOSE TISSUE.
- NEGATIVE FOR MALIGNANCY.
B. EYELID, RIGHT LOWER, BLEPHAROPLASTY:
- BENIGN SKIN WITH MILD SOLAR ELASTOSIS.
- BENIGN SKELETAL MUSCLE AND ADIPOSE TISSUE.
- NEGATIVE FOR MALIGNANCY.
- NEGATIVE FOR MALIGNANCY.
</pre>
</pre>


==Papilloma of the caruncle==
==Papilloma of the caruncle==
*[[AKA]] ''caruncle papilloma''.
{{Main|Eye papilloma}}
===General===
 
*Benign.
==Corneal ulcer==
*Second most common caruncle tumour ~ 15% of caruncle tumours.<ref name=pmid16935590>{{Cite journal  | last1 = Kaeser | first1 = PF. | last2 = Uffer | first2 = S. | last3 = Zografos | first3 = L. | last4 = Hamédani | first4 = M. | title = Tumors of the caruncle: a clinicopathologic correlation. | journal = Am J Ophthalmol | volume = 142 | issue = 3 | pages = 448-55 | month = Sep | year = 2006 | doi = 10.1016/j.ajo.2006.04.035 | PMID = 16935590 }}</ref>
{{Main|Corneal ulcer}}
**Most common is [[nevus]] ~ 50% of caruncle tumours.


===Gross===
==Keratoconus==
*Frond-like lesion.
{{Main|Keratoconus}}


Image:
==Corneal scar==
*[http://www.atlasophthalmology.com/atlas/photo.jsf?node=2748&locale=en Papilloma of caruncle (atlasophthalmology.com)].
===General===
*Trauma to the cornea.


===Microscopic===
===Microscopic===
Features:<ref name=pmid16935590/>
Features:
*Fibrovascular fronds in a cauliflower-like arrangement.
*Compact hyaline tissue - darker staining.
*No nuclear atypia.
*Fibroblasts.


Image:
DDx:
*[http://www.atlasophthalmology.com/atlas/photo.jsf?node=4686&locale=en Papilloma of caruncle - crappy image (atlasophthalmology.com)].  
*Squamous dysplasia.


===Sign out===
===Sign out===
<pre>
<pre>
LESION, RIGHT CARUNCLE, EXCISION:
Corneal Button, Right Eye, Keratoplasty:
- PAPILLOMA.
- Consistent with corneal scar.
- NEGATIVE FOR MALIGNANCY.
- NEGATIVE for dysplasia.
</pre>
</pre>


====Micro====
==Conjunctival nevus==
The sections show benign conjunctival mucosa and a lesion consisting of fibrovascular
{{Main|Conjunctival nevus}}
cores covered by a conjunctival epithelium with a cauliflower-like appearance at low
power. Parakeratosis is present. No significant nuclear atypia is identified. No koilocytic
change is seen. No mitotic activity is appreciated.


===External links===
=Tumours of the eye=
*[http://eyewiki.aao.org/Conjunctival_Papilloma Conjunctival papilloma (eyewiki.aao.org)].
==Optic glioma==
===General===
*Associated with [[Neurofibromatosis]] type 1.
* Often nerve sheath thickening or tortuosity.
* Approx 3% of all pediatric gliomas.
* Histology in most cases a [[pilocytic astrocytoma]].


=Malignant entities=
==Retinoblastoma==
==Retinoblastoma==
===General===
{{Main|Retinoblastoma}}
*Rare.
*Malignant.
*May be familial.<ref name=pmid20687510>{{cite journal |author=Lohmann D |title=Retinoblastoma |journal=Adv. Exp. Med. Biol. |volume=685 |issue= |pages=220–7 |year=2010 |pmid=20687510 |doi= |url=}}</ref>
 
===Gross===
*White, solid.
*Patterns:
**Endophytic - grow into the  vitreous cavity.
**Exophytic - grow toward choroid.
**Mixed - components of endophytic and exophytic.
 
Image:
*[http://radiopaedia.org/cases/retinoblastoma-gross-pathology Retinoblastoma (radiopaedia.org/AFIP)].
 
Note:
*Tumour is extremely friable.
 
===Microscopic===
Features:
*[[Small round cell tumour]]:
**Scant cytoplasm.
*Flexner-Wintersteiner [[rosette]] - '''key feature'''.
**Rosette with empty centre (donut hole).<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref>
*+/-Homer-Wright rosette.<ref>WH. 14 March 2011.</ref>
**Circular rosette with neuropil at the centre.<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref>
*Mitoses - common.
*+/-Necrosis.
*+/-Calcification.
 
DDx:
*Retinocytoma (retinoma) - benign counterpart of retinoblastoma.
 
Notes:
*DDx of Flexner-Wintersteiner rosette includes:
**Pineoblastoma.
**Medulloepithelioma.
 
Image:
*[http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/O0A001-PQ01-M.htm Retinoblastoma (ouhsc.edu)].
*[http://www.pathpedia.com/Education/eAtlas/Histopathology/eye_and_ocular_adnexa/retinoblastoma.aspx Retinoblastoma (pathpedia.com)].


==Malignant melanoma==
==Malignant melanoma==
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*[[Lacrimal gland]].
*[[Lacrimal gland]].
*[[Neuropathology]].
*[[Neuropathology]].
*[[Descemet's membrane]].


=References=
=References=
{{Reflist|2}}
{{Reflist|2}}


[[Category:Weird stuff]]
[[Category:Eye]]
[[Category:Neuropathology]]
[[Category:Neuropathology]]
Michael
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