Difference between revisions of "Extranodal NK/T-cell lymphoma, nasal type"
Jump to navigation
Jump to search
(tweaek) |
(→IHC: wikify) |
||
| (One intermediate revision by the same user not shown) | |||
| Line 4: | Line 4: | ||
*Common in east Asia.<ref name=pmid18283711>{{Cite journal | last1 = Suzuki | first1 = R. | last2 = Takeuchi | first2 = K. | last3 = Ohshima | first3 = K. | last4 = Nakamura | first4 = S. | title = Extranodal NK/T-cell lymphoma: diagnosis and treatment cues. | journal = Hematol Oncol | volume = 26 | issue = 2 | pages = 66-72 | month = Jun | year = 2008 | doi = 10.1002/hon.847 | PMID = 18283711 }}</ref> | *Common in east Asia.<ref name=pmid18283711>{{Cite journal | last1 = Suzuki | first1 = R. | last2 = Takeuchi | first2 = K. | last3 = Ohshima | first3 = K. | last4 = Nakamura | first4 = S. | title = Extranodal NK/T-cell lymphoma: diagnosis and treatment cues. | journal = Hematol Oncol | volume = 26 | issue = 2 | pages = 66-72 | month = Jun | year = 2008 | doi = 10.1002/hon.847 | PMID = 18283711 }}</ref> | ||
*Strong association with [[EBV]]. | *Strong association with [[EBV]]. | ||
*Poor prognosis.<ref name=pmid23652805>{{Cite journal | last1 = Tse | first1 = E. | last2 = Kwong | first2 = YL. | title = How I treat NK/T-cell lymphomas. | journal = Blood | volume = 121 | issue = 25 | pages = 4997-5005 | month = Jun | year = 2013 | doi = 10.1182/blood-2013-01-453233 | PMID = 23652805 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
| Line 26: | Line 27: | ||
*TIA-1 +ve. | *TIA-1 +ve. | ||
*CD7 +ve. | *CD7 +ve. | ||
*EBER +ve. | *[[EBER]] +ve. | ||
==See also== | ==See also== | ||
Latest revision as of 19:57, 26 December 2019
Extranodal NK/T-cell lymphoma, nasal type (abbreviated ENKTCL), also known as extranodal natural kill lymphoma (abbreviated ENKL) and angiocentric lymphoma, is a rare type of lymphoma.
General
Microscopic
Features:
- Atypical lymphoid cells:
- Nucleoli.
- Nuclear pleomorphism.
- Cells centered around vessels (angiocentric).
- May destroy small and medium sized arterioles.
Images:
- Extranodal NK/T-cell lymphoma, nasal type - case 1 - several images (upmc.edu).
- Extranodal NK/T-cell lymphoma, nasal type - case 2 - several images (upmc.edu).
IHC
Features:[3]
- CD2 +ve.
- CD3 +ve (cytoplasmic).
- CD56 +ve.
Others:[4]
- TIA-1 +ve.
- CD7 +ve.
- EBER +ve.
See also
References
- ↑ Suzuki, R.; Takeuchi, K.; Ohshima, K.; Nakamura, S. (Jun 2008). "Extranodal NK/T-cell lymphoma: diagnosis and treatment cues.". Hematol Oncol 26 (2): 66-72. doi:10.1002/hon.847. PMID 18283711.
- ↑ Tse, E.; Kwong, YL. (Jun 2013). "How I treat NK/T-cell lymphomas.". Blood 121 (25): 4997-5005. doi:10.1182/blood-2013-01-453233. PMID 23652805.
- ↑ Al-Hakeem, DA.; Fedele, S.; Carlos, R.; Porter, S. (Jan 2007). "Extranodal NK/T-cell lymphoma, nasal type.". Oral Oncol 43 (1): 4-14. doi:10.1016/j.oraloncology.2006.03.011. PMID 17064952.
- ↑ URL: http://path.upmc.edu/cases/case310.html. Accessed on: 14 January 2012.