Difference between revisions of "Extranodal NK/T-cell lymphoma, nasal type"

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#redirect [[Lymphoma#Extranodal_NK.2FT-cell_lymphoma.2C_nasal_type]]
'''Extranodal NK/T-cell lymphoma, nasal type''' (abbreviated '''ENKTCL'''), also known as '''extranodal natural kill lymphoma''' (abbreviated '''ENKL''') and '''angiocentric lymphoma''', is a rare type of [[lymphoma]].
 
==General==
*Common in east Asia.<ref name=pmid18283711>{{Cite journal  | last1 = Suzuki | first1 = R. | last2 = Takeuchi | first2 = K. | last3 = Ohshima | first3 = K. | last4 = Nakamura | first4 = S. | title = Extranodal NK/T-cell lymphoma: diagnosis and treatment cues. | journal = Hematol Oncol | volume = 26 | issue = 2 | pages = 66-72 | month = Jun | year = 2008 | doi = 10.1002/hon.847 | PMID = 18283711 }}</ref>
*Strong association with [[EBV]].
*Poor prognosis.<ref  name=pmid23652805>{{Cite journal  | last1 = Tse | first1 = E. | last2 = Kwong | first2 = YL. | title = How I treat NK/T-cell lymphomas. | journal = Blood | volume = 121 | issue = 25 | pages = 4997-5005 | month = Jun | year = 2013 | doi = 10.1182/blood-2013-01-453233 | PMID = 23652805 }}</ref>
 
==Microscopic==
Features:
*Atypical lymphoid cells:
**[[Nucleoli]].
**[[Nuclear pleomorphism]].
**Cells centered around vessels (angiocentric).
***May destroy small and medium sized arterioles.
 
Images:
*[http://path.upmc.edu/cases/case231/micro.html Extranodal NK/T-cell lymphoma, nasal type - case 1 - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case310.html Extranodal NK/T-cell lymphoma, nasal type - case 2 - several images (upmc.edu)].
 
==IHC==
Features:<ref name=pmid17064952>{{Cite journal  | last1 = Al-Hakeem | first1 = DA. | last2 = Fedele | first2 = S. | last3 = Carlos | first3 = R. | last4 = Porter | first4 = S. | title = Extranodal NK/T-cell lymphoma, nasal type. | journal = Oral Oncol | volume = 43 | issue = 1 | pages = 4-14 | month = Jan | year = 2007 | doi = 10.1016/j.oraloncology.2006.03.011 | PMID = 17064952 }}</ref>
*CD2 +ve.
*CD3 +ve (cytoplasmic).
*[[CD56]] +ve.
 
Others:<ref>URL: [http://path.upmc.edu/cases/case310.html http://path.upmc.edu/cases/case310.html]. Accessed on: 14 January 2012.</ref>
*TIA-1 +ve.
*CD7 +ve.
*[[EBER]] +ve.
 
==See also==
*[[Lymphoma]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]

Latest revision as of 19:57, 26 December 2019

Extranodal NK/T-cell lymphoma, nasal type (abbreviated ENKTCL), also known as extranodal natural kill lymphoma (abbreviated ENKL) and angiocentric lymphoma, is a rare type of lymphoma.

General

  • Common in east Asia.[1]
  • Strong association with EBV.
  • Poor prognosis.[2]

Microscopic

Features:

  • Atypical lymphoid cells:

Images:

IHC

Features:[3]

  • CD2 +ve.
  • CD3 +ve (cytoplasmic).
  • CD56 +ve.

Others:[4]

  • TIA-1 +ve.
  • CD7 +ve.
  • EBER +ve.

See also

References

  1. ↑ Suzuki, R.; Takeuchi, K.; Ohshima, K.; Nakamura, S. (Jun 2008). "Extranodal NK/T-cell lymphoma: diagnosis and treatment cues.". Hematol Oncol 26 (2): 66-72. doi:10.1002/hon.847. PMID 18283711.
  2. ↑ Tse, E.; Kwong, YL. (Jun 2013). "How I treat NK/T-cell lymphomas.". Blood 121 (25): 4997-5005. doi:10.1182/blood-2013-01-453233. PMID 23652805.
  3. ↑ Al-Hakeem, DA.; Fedele, S.; Carlos, R.; Porter, S. (Jan 2007). "Extranodal NK/T-cell lymphoma, nasal type.". Oral Oncol 43 (1): 4-14. doi:10.1016/j.oraloncology.2006.03.011. PMID 17064952.
  4. ↑ URL: http://path.upmc.edu/cases/case310.html. Accessed on: 14 January 2012.
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