Extramammary Paget disease

Extramammary Paget disease is a skin disease. As the name suggests, there is also a Paget disease of the breast.

There is also a Paget disease of the bone - just to make things confusing. This is dealt with in the bone article and has nothing (from a pathologic perspective) to do with the Paget disease discussed in this article

General

• Usually not associated with malignancy, unlike the Paget disease of the breast - important difference.
• Classically seen in the vulva.
• May afflict penis.

Microscopic

Features:

• Epitheliod morphology (round/ovoid).
• Cells nested or single.
• Clear/pale cytoplasm key feature - may also be eosinophilic.
• Large nucleoli.

Images:

• Paget's disease - low mag. (WC).
• Paget's disease - high mag. (WC).

DDx

• Benign Toker cell hyperplasia.
• Malignant melanoma.
• Bowen disease.
• Nipple (duct) adenoma (clinical DDx).

See also

• Paget disease.