Difference between revisions of "Exaggerated placental site"

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#redirect [[Gestational_trophoblastic_disease#Exaggerated_placental_site]]
'''Exaggerated placental site''', abbreviated '''EPS''', is an uncommon benign pathology that is a
[[gestational trophoblastic disease]].
 
It was previously known as '''syncytial endometritis'''.<ref>URL: [http://www.webpathology.com/image.asp?case=565&n=7 http://www.webpathology.com/image.asp?case=565&n=7]. Accessed on: 22 May 2014.</ref><ref name=pmid7014653>{{cite journal |author=Heyderman E, Gibbons AR, Rosen SW |title=Immunoperoxidase localisation of human placental lactogen: a marker for the placental origin of the giant cells in 'syncytial endometritis' of pregnancy |journal=J. Clin. Pathol. |volume=34 |issue=3 |pages=303–7 |year=1981 |month=March |pmid=7014653 |pmc=1146481 |doi= |url=}}</ref>
 
==General==
*Benign.
 
Definition:
*"Increased number" of implantation-site [[Intermediate trophoblast|intermediate trophoblastic cells]].
 
Note:
*Used to go by a terrible old term: ''syncytial endometritis'':<ref name=ouhsc_kfung>URL: [http://moon.ouhsc.edu/kfung/IACP-OLP/TC-Text/TC-01-Supp.pdf http://moon.ouhsc.edu/kfung/IACP-OLP/TC-Text/TC-01-Supp.pdf]. Accessed on: 15 August 2011.</ref>
**Not syncytial -- mostly.
**Not inflammatory.
==Microscopic==
Features:<ref name=ouhsc_kfung/>
*Intermediate trophoblast:
**Abundant (eosinophilic) cytoplasm.
*Usu. adjacent to:
**[[Chorionic villi]].
**Decidua - endometrial stromal cells with a nucleus central, eosinphilic cytoplasm, well-defined cell borders.
*No mitotic activity.
*Ectatic blood vessels.
 
DDx:
*[[PSTT]].
 
===Image===
*[http://www.webpathology.com/image.asp?case=565&n=7 EPS (webpathology.com)].
 
==IHC==
*MIB1 ~0%.
**Used to differentiate from [[PSTT]].
*hPL +ve.<ref name=pmid7014653>{{cite journal |author=Heyderman E, Gibbons AR, Rosen SW |title=Immunoperoxidase localisation of human placental lactogen: a marker for the placental origin of the giant cells in 'syncytial endometritis' of pregnancy |journal=J. Clin. Pathol. |volume=34 |issue=3 |pages=303–7 |year=1981 |month=March |pmid=7014653 |pmc=1146481 |doi= |url=}}</ref><ref name=pmid15498215/>
*CK18 +ve.<ref name=pmid15498215>{{cite journal |author=Shen DH, Liao XY, Liu YL, Wang H, Yu YZ |title=[Clinicopathological study of intermediate trophoblastic non-tumor lesions: exaggerated placental site and placental site nodule] |language=Chinese |journal=Zhonghua Bing Li Xue Za Zhi |volume=33 |issue=5 |pages=441–4 |year=2004 |month=October |pmid=15498215 |doi= |url=}}</ref>
 
==See also==
*[[Gestational trophoblastic disease]].
*[[Endometritis]].
 
==References==
{{Reflist|2}}
 
[[Category:Gestational trophoblastic disease]]
[[Category:Diagnosis]]

Latest revision as of 11:12, 7 July 2014

Exaggerated placental site, abbreviated EPS, is an uncommon benign pathology that is a gestational trophoblastic disease.

It was previously known as syncytial endometritis.[1][2]

General

  • Benign.

Definition:

Note:

  • Used to go by a terrible old term: syncytial endometritis:[3]
    • Not syncytial -- mostly.
    • Not inflammatory.

Microscopic

Features:[3]

  • Intermediate trophoblast:
    • Abundant (eosinophilic) cytoplasm.
  • Usu. adjacent to:
    • Chorionic villi.
    • Decidua - endometrial stromal cells with a nucleus central, eosinphilic cytoplasm, well-defined cell borders.
  • No mitotic activity.
  • Ectatic blood vessels.

DDx:

Image

IHC

  • MIB1 ~0%.
    • Used to differentiate from PSTT.
  • hPL +ve.[2][4]
  • CK18 +ve.[4]

See also

References

  1. ↑ URL: http://www.webpathology.com/image.asp?case=565&n=7. Accessed on: 22 May 2014.
  2. ↑ 2.0 2.1 Heyderman E, Gibbons AR, Rosen SW (March 1981). "Immunoperoxidase localisation of human placental lactogen: a marker for the placental origin of the giant cells in 'syncytial endometritis' of pregnancy". J. Clin. Pathol. 34 (3): 303–7. PMC 1146481. PMID 7014653. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1146481/.
  3. ↑ 3.0 3.1 URL: http://moon.ouhsc.edu/kfung/IACP-OLP/TC-Text/TC-01-Supp.pdf. Accessed on: 15 August 2011.
  4. ↑ 4.0 4.1 Shen DH, Liao XY, Liu YL, Wang H, Yu YZ (October 2004). "[Clinicopathological study of intermediate trophoblastic non-tumor lesions: exaggerated placental site and placental site nodule]" (in Chinese). Zhonghua Bing Li Xue Za Zhi 33 (5): 441–4. PMID 15498215.
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