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Difference between revisions of "Ewing sarcoma"
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = Ewing sarcoma - PAS - high mag.jpg | | Image = Ewing sarcoma - PAS - high mag.jpg | ||
| Width = | | Width = | ||
| Caption = Ewing sarcoma. [[ | | Caption = Ewing sarcoma. [[PAS stain]]. | ||
| Micro = [[small round cell tumour]], clear cytoplasm | | Micro = [[small round cell tumour]], clear cytoplasm | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[small round cell tumours]] ([[lymphoma]], [[small cell osteosarcoma]], others) | | LMDDx = [[Ewing-like tumours]] (e.g. [[CIC-DUX sarcoma]]), [[small round cell tumours]] ([[lymphoma]], [[small cell osteosarcoma]], others) | ||
| Stains = [[PAS stain]] +ve, [[PASD stain]] -ve | | Stains = [[PAS stain]] +ve, [[PASD stain]] -ve | ||
| IHC = CD99 +ve, FLI-1 +ve, CD45 -ve | | IHC = [[CD99]] +ve, FLI-1 +ve, CD45 -ve | ||
| EM = | | EM = | ||
| Molecular = EWS [[Chromosomal translocations|translocation]], EWS/FLI-1 fusion gene in 90% of cases | | Molecular = EWS [[Chromosomal translocations|translocation]], EWS/FLI-1 fusion gene in 90% of cases | ||
| Line 69: | Line 69: | ||
*It is a [[small round cell tumour]]. | *It is a [[small round cell tumour]]. | ||
*[[Rhabdomyosarcoma]] occasionally has cytoplasmic clearing (due to glycogen).<ref name=PST14feb11>PST. 14 February 2011.</ref> | *[[Rhabdomyosarcoma]] occasionally has cytoplasmic clearing (due to glycogen).<ref name=PST14feb11>PST. 14 February 2011.</ref> | ||
DDx: | |||
*[[Ewing-like tumours]] (e.g. [[CIC-DUX sarcoma]]). | |||
*Large cell [[lymphoma]]. | |||
*Other [[small round cell tumours]] (e.g. small cell [[osteosarcoma]]). | |||
====Images==== | ====Images==== | ||
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Notes:<ref>PST. 22 February 2010.</ref> | Notes:<ref>PST. 22 February 2010.</ref> | ||
*CD99 +ve | *[[CD99]] +ve | ||
**Plasma membrane staining tumours: | **Plasma membrane staining tumours: | ||
***[[Lymphoblastic lymphoma]]/leukemia. | ***[[Lymphoblastic lymphoma]]/leukemia. | ||