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Difference between revisions of "Ewing sarcoma"
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Ewing sarcoma - PAS - high mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Ewing sarcoma. [[H&E stain]]. | ||
| Micro = | | Micro = [[small round cell tumour]], clear cytoplasm | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[small round cell tumours]] | | LMDDx = [[small round cell tumours]] ([[lymphoma]], [[small cell osteosarcoma]], others) | ||
| Stains = [[PAS stain]] +ve, [[PASD stain]] -ve | | Stains = [[PAS stain]] +ve, [[PASD stain]] -ve | ||
| IHC = | | IHC = CD99 +ve, FLI-1 +ve, CD45 -ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = EWS [[molecular translocation|translocation]], EWS/FLI-1 fusion gene in 90% of cases | ||
| IF = | | IF = | ||
| Gross = | | Gross = | ||
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| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = | | Clinicalhx = usually <20 years old | ||
| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = | | Prevalence = uncommon | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = | ||
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*Usually younger than 20 years. | *Usually younger than 20 years. | ||
*Second most common malignant bone tumour in children. | *Second most common malignant bone tumour in children. | ||
**Most common malignant bone tumour = osteosarcoma (AKA osteogenic sarcoma). | **Most common malignant bone tumour = [[osteosarcoma]] ([[AKA]] ''osteogenic sarcoma''). | ||
Poor prognostic factors:<ref>PST. 14 February 2011.</ref> | Poor prognostic factors:<ref>PST. 14 February 2011.</ref> | ||
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*CD45 -ve. | *CD45 -ve. | ||
**Done to r/o [[lymphoma]]. | **Done to r/o [[lymphoma]]. | ||
*+/-Neural markers (NSE, synaptophysin, CD57 (??? CD56 ???), | *+/-Neural markers (NSE, synaptophysin, CD57 (??? CD56 ???), S-100). | ||
*+/-Cytokeratins. | *+/-Cytokeratins. | ||
*Caveolin-1 +ve in ~ 85% of EWS.<ref>PST. 14 February 2011.</ref> | *Caveolin-1 +ve in ~ 85% of EWS.<ref>PST. 14 February 2011.</ref> | ||