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Difference between revisions of "Epithelioid sarcoma"
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Epithelioid sarcoma (view source)
Revision as of 15:22, 28 September 2013
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| Micro = epithelioid morphology and spindle morphology (predominant pattern dependent on location), +/-prominent nucleolus, zonal necrosis with an irregular border | | Micro = epithelioid morphology and spindle morphology (predominant pattern dependent on location), +/-prominent nucleolus, zonal necrosis with an irregular border | ||
| Subtypes = proximal type, distal type | | Subtypes = proximal type, distal type | ||
| LMDDx = carcinoma, [[rheumatoid nodule]], [[granuloma annulare]] | | LMDDx = carcinoma, [[rheumatoid nodule]], [[granuloma annulare]], [[malignant rhabdoid tumour]] | ||
| Stains = | | Stains = | ||
| IHC = INI1 -ve | | IHC = INI1 -ve, CK7 +ve, vimentin +ve, S-100 -ve, CD34 +ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
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| Symptoms = mass lesion | | Symptoms = mass lesion | ||
| Prevalence = rare | | Prevalence = rare | ||
| Bloodwork = | | Bloodwork = CA-125 elevated | ||
| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
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:Sarcomas with an epithelioid morphology are covered in ''[[epithelioid sarcomas]]''. | :Sarcomas with an epithelioid morphology are covered in ''[[epithelioid sarcomas]]''. | ||
==General== | |||
*Rare. | *Rare. | ||
*Adolescents, young adults. | *Adolescents, young adults. | ||
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*Distal type: | *Distal type: | ||
==Microscopic== | |||
Features:<ref>{{Ref WHOSTAB|205}}</ref> | Features:<ref>{{Ref WHOSTAB|205}}</ref> | ||
*Epithelioid morphology and spindle morphology - which predominates is dependent on location (see subclassification). | *Epithelioid morphology and spindle morphology - which predominates is dependent on location (see subclassification). | ||
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*[[Rheumatoid nodule]]. | *[[Rheumatoid nodule]]. | ||
*[[Granuloma annulare]]. | *[[Granuloma annulare]]. | ||
*[[Malignant rhabdoid tumour]]. | |||
===Images=== | |||
<gallery> | <gallery> | ||
Image:Epithelioid_sarcoma_-_intermed_mag.jpg | ES - intermed. mag. (WC/Nephron) | Image:Epithelioid_sarcoma_-_intermed_mag.jpg | ES - intermed. mag. (WC/Nephron) | ||
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*[http://path.upmc.edu/cases/case594.html ES - several images (upmc.edu)]. | *[http://path.upmc.edu/cases/case594.html ES - several images (upmc.edu)]. | ||
==IHC== | |||
Features:<ref name=pmid10452506>{{cite journal |author=Miettinen M, Fanburg-Smith JC, Virolainen M, Shmookler BM, Fetsch JF |title=Epithelioid sarcoma: an immunohistochemical analysis of 112 classical and variant cases and a discussion of the differential diagnosis |journal=Hum. Pathol. |volume=30 |issue=8 |pages=934–42 |year=1999 |month=August |pmid=10452506 |doi= |url=}}</ref> | Features:<ref name=pmid10452506>{{cite journal |author=Miettinen M, Fanburg-Smith JC, Virolainen M, Shmookler BM, Fetsch JF |title=Epithelioid sarcoma: an immunohistochemical analysis of 112 classical and variant cases and a discussion of the differential diagnosis |journal=Hum. Pathol. |volume=30 |issue=8 |pages=934–42 |year=1999 |month=August |pmid=10452506 |doi= |url=}}</ref> | ||
*INI1 (SMARCB1<ref>{{OMIM|601607}}</ref>) -ve.<ref name=pmid19997734>{{cite journal |author=Mentzel T |title=[Epithelioid sarcoma: morphologic variants and differential diagnosis] |language=German |journal=Pathologe |volume=31 |issue=2 |pages=135–41 |year=2010 |month=March |pmid=19997734 |doi=10.1007/s00292-009-1250-0 |url=}}</ref> | *INI1 (SMARCB1<ref>{{OMIM|601607}}</ref>) -ve.<ref name=pmid19997734>{{cite journal |author=Mentzel T |title=[Epithelioid sarcoma: morphologic variants and differential diagnosis] |language=German |journal=Pathologe |volume=31 |issue=2 |pages=135–41 |year=2010 |month=March |pmid=19997734 |doi=10.1007/s00292-009-1250-0 |url=}}</ref> | ||
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*CK7 +ve / CK20 -ve.<ref name=pmid12680954>{{Cite journal | last1 = Humble | first1 = SD. | last2 = Prieto | first2 = VG. | last3 = Horenstein | first3 = MG. | title = Cytokeratin 7 and 20 expression in epithelioid sarcoma. | journal = J Cutan Pathol | volume = 30 | issue = 4 | pages = 242-6 | month = Apr | year = 2003 | doi = | PMID = 12680954 }}</ref> | *CK7 +ve / CK20 -ve.<ref name=pmid12680954>{{Cite journal | last1 = Humble | first1 = SD. | last2 = Prieto | first2 = VG. | last3 = Horenstein | first3 = MG. | title = Cytokeratin 7 and 20 expression in epithelioid sarcoma. | journal = J Cutan Pathol | volume = 30 | issue = 4 | pages = 242-6 | month = Apr | year = 2003 | doi = | PMID = 12680954 }}</ref> | ||
*CA-125 +ve.<ref name=pmid19756736/><ref name=pmid16740043>{{Cite journal | last1 = Lee | first1 = HI. | last2 = Kang | first2 = KH. | last3 = Cho | first3 = YM. | last4 = Lee | first4 = OJ. | last5 = Ro | first5 = JY. | title = Proximal-type epithelioid sarcoma with elevated serum CA 125: report of a case with CA 125 immunoreactivity. | journal = Arch Pathol Lab Med | volume = 130 | issue = 6 | pages = 871-4 | month = Jun | year = 2006 | doi = 10.1043/1543-2165(2006)130[871:PESWES]2.0.CO;2 | PMID = 16740043 }}</ref> | *CA-125 +ve.<ref name=pmid19756736/><ref name=pmid16740043>{{Cite journal | last1 = Lee | first1 = HI. | last2 = Kang | first2 = KH. | last3 = Cho | first3 = YM. | last4 = Lee | first4 = OJ. | last5 = Ro | first5 = JY. | title = Proximal-type epithelioid sarcoma with elevated serum CA 125: report of a case with CA 125 immunoreactivity. | journal = Arch Pathol Lab Med | volume = 130 | issue = 6 | pages = 871-4 | month = Jun | year = 2006 | doi = 10.1043/1543-2165(2006)130[871:PESWES]2.0.CO;2 | PMID = 16740043 }}</ref> | ||
==See also== | ==See also== | ||