Difference between revisions of "Epidermal growth factor receptor inhibitors"
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Jensflorian (talk | contribs) (EGFR) |
Jensflorian (talk | contribs) (mutations) |
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*EGFR (aka. ErbB1 or HER1) is a membranous receptor expressed in epithelial cells. | *EGFR (aka. ErbB1 or HER1) is a membranous receptor expressed in epithelial cells. | ||
*Most of activating mutations in [[NSCLC]] are in Exon 18-21 (kinase domain). | *Most of activating mutations in [[NSCLC]] are in Exon 18-21 (kinase domain). | ||
*45% of the mutations are p.DEL19, approx 40-45% are p.L858R, approx 2% are p.T790M. | |||
==Drugs== | ==Drugs== | ||