Eosinophilic vacuolated tumour

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Eosinophilic vacuolated tumour
Diagnosis in short

Micrograph of a high-grade oncocytic tumour of the kidney. H&E stain.

LM

abundant oncocytic cytoplasm with prominent intracytoplasmic vacuoles,

round nuclei, prominent nucleoli (ISUP nucleolar grade 3), no perinuclear halos
LM DDx renal oncocytoma, renal hybrid oncocytic/chromophobe tumour, chromophobe renal cell carcinoma, other renal tumours with eosinophilic cytoplasm
IHC PAX8 +ve, CD117 +ve, CD10 +ve, SDHB +ve, TFE3 -ve
Site kidney - see kidney tumours

Syndromes tuberous sclerosis

Prevalence very rare? (evolving entity)
Prognosis unknown (evolving entity)
Clin. DDx other renal tumours
Treatment excision

High-grade oncocytic renal tumour, abbreviated HOT, is a kidney tumour type currently not recognized by the WHO classification as per the 2016 Blue Book.

General

Microscopic

Features:[2]

  • Abundant oncocytic cytoplasm with prominent intracytoplasmic vacuoles.
  • Round nuclei
  • Prominent nucleoli (ISUP nucleolar grade 3).
  • No perinuclear halos.

DDx:

Images

IHC

Features:[2]

  • PAX8 +ve.
  • AE1/AE3 +ve.
  • CK18 +ve.
  • SDHB +ve.
  • CD10 +ve (12 of 13 cases).
  • HMB45 -ve.
  • Melan A -ve.
  • TFE3 -ve.
  • CD117 +ve (9 of 14 cases).

See also

References

  1. Trpkov, K.; Bonert, M.; Gao, Y.; Kapoor, A.; He, H.; Yilmaz, A.; Gill, AJ.; Williamson, SR. et al. (Apr 2019). "High-grade oncocytic tumour (HOT) of kidney in a patient with tuberous sclerosis complex.". Histopathology. doi:10.1111/his.13876. PMID 31002177.
  2. 2.0 2.1 He, H.; Trpkov, K.; Martinek, P.; Isikci, OT.; Maggi-Galuzzi, C.; Alaghehbandan, R.; Gill, AJ.; Tretiakova, M. et al. (Dec 2018). ""High-grade oncocytic renal tumor": morphologic, immunohistochemical, and molecular genetic study of 14 cases.". Virchows Arch 473 (6): 725-738. doi:10.1007/s00428-018-2456-4. PMID 30232607.