Difference between revisions of "Eosinophilic vacuolated tumour"
Jump to navigation
Jump to search
| Line 6: | Line 6: | ||
==Microscopic== | ==Microscopic== | ||
Features:<ref name=pmid30232607>{{Cite journal | last1 = He | first1 = H. | last2 = Trpkov | first2 = K. | last3 = Martinek | first3 = P. | last4 = Isikci | first4 = OT. | last5 = Maggi-Galuzzi | first5 = C. | last6 = Alaghehbandan | first6 = R. | last7 = Gill | first7 = AJ. | last8 = Tretiakova | first8 = M. | last9 = Lopez | first9 = JI. | title = "High-grade oncocytic renal tumor": morphologic, immunohistochemical, and molecular genetic study of 14 cases. | journal = Virchows Arch | volume = 473 | issue = 6 | pages = 725-738 | month = Dec | year = 2018 | doi = 10.1007/s00428-018-2456-4 | PMID = 30232607 }}</ref> | Features:<ref name=pmid30232607>{{Cite journal | last1 = He | first1 = H. | last2 = Trpkov | first2 = K. | last3 = Martinek | first3 = P. | last4 = Isikci | first4 = OT. | last5 = Maggi-Galuzzi | first5 = C. | last6 = Alaghehbandan | first6 = R. | last7 = Gill | first7 = AJ. | last8 = Tretiakova | first8 = M. | last9 = Lopez | first9 = JI. | title = "High-grade oncocytic renal tumor": morphologic, immunohistochemical, and molecular genetic study of 14 cases. | journal = Virchows Arch | volume = 473 | issue = 6 | pages = 725-738 | month = Dec | year = 2018 | doi = 10.1007/s00428-018-2456-4 | PMID = 30232607 }}</ref> | ||
* | *Abundant oncocytic cytoplasm with prominent intracytoplasmic vacuoles. | ||
*Prominent nucleoli. | *Round nuclei | ||
**No "raisinoid" nuclei typical of chromophobe RCC. | |||
*Prominent nucleoli ([[ISUP nucleolar grade]] 3). | |||
*No perinuclear halos. | |||
DDx: | DDx: | ||
*[[Renal oncocytoma]]. | *[[Renal oncocytoma]]. | ||
*[[Renal hybrid oncocytic/chromophobe tumour]]. | *[[Renal hybrid oncocytic/chromophobe tumour]]. | ||
*[[ | *[[Chromophobe renal cell carcinoma]]. | ||
*Other [[renal tumours with eosinophilic cytoplasm]]. | |||
==See also== | ==See also== | ||
Revision as of 14:00, 6 February 2019
High-grade oncocytic renal tumour, abbreviated HOT, is a kidney tumour type currently not recognized by the WHO classification as per the 2016 Blue Book.
General
- Previously lumped into renal hybrid oncocytic/chromophobe tumour.
Microscopic
Features:[1]
- Abundant oncocytic cytoplasm with prominent intracytoplasmic vacuoles.
- Round nuclei
- No "raisinoid" nuclei typical of chromophobe RCC.
- Prominent nucleoli (ISUP nucleolar grade 3).
- No perinuclear halos.
DDx:
- Renal oncocytoma.
- Renal hybrid oncocytic/chromophobe tumour.
- Chromophobe renal cell carcinoma.
- Other renal tumours with eosinophilic cytoplasm.
See also
References
- ↑ He, H.; Trpkov, K.; Martinek, P.; Isikci, OT.; Maggi-Galuzzi, C.; Alaghehbandan, R.; Gill, AJ.; Tretiakova, M. et al. (Dec 2018). ""High-grade oncocytic renal tumor": morphologic, immunohistochemical, and molecular genetic study of 14 cases.". Virchows Arch 473 (6): 725-738. doi:10.1007/s00428-018-2456-4. PMID 30232607.