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Difference between revisions of "Eosinophilic gastritis"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Stomach_with_eosinophilia_-_2_--_high_mag.jpg | |||
| Width = | |||
| Caption = Stomach with eosinophilia. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = abundant eosinophils (>=127 eosinophils/mm<sup>2</sup>) | |||
| Subtypes = | |||
| LMDDx = [[chronic gastritis]], [[Helicobacter gastritis]], [[Crohn's disease]] - see ''[[inflammatory bowel disease and the stomach]]'', eosinophilic myeloproliferative neoplasm, eosinophilic gastroenteritis | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[stomach]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = +/-abdominal pain | |||
| Prevalence = very rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign? | |||
| Other = | |||
| ClinDDx = other causes of [[gastritis]] | |||
| Tx = | |||
}} | |||
'''Eosinophilic gastritis''', abbreviated '''EG''', is an uncommon inflammatory process of [[stomach]] characterized by abundant [[eosinophil]]s. | |||
==General== | |||
*Rare. | |||
Clinical: | |||
*Abdominal pain.<ref name=pmid18693615>{{Cite journal | last1 = Ayyub | first1 = M. | last2 = Almenawi | first2 = L. | last3 = Mogharbel | first3 = MH. | title = Eosinophilic gastritis; an unusual and overlooked cause of chronic abdominal pain. | journal = J Ayub Med Coll Abbottabad | volume = 19 | issue = 4 | pages = 127-30 | month = | year = | doi = | PMID = 18693615 }}</ref> | |||
*May mimic a gastric tumour.<ref name=pmid20501003>{{Cite journal | last1 = Holroyd | first1 = DJ. | last2 = Banerjee | first2 = S. | last3 = Chaudhary | first3 = KS. | last4 = Reshamwalla | first4 = S. | last5 = Vijay | first5 = V. | last6 = Ward | first6 = MW. | title = Transmural eosinophilic gastritis with gastric outlet obstruction: case report and review of the literature. | journal = Ann R Coll Surg Engl | volume = 92 | issue = 4 | pages = W18-20 | month = May | year = 2010 | doi = 10.1308/147870810X12659688851915 | PMID = 20501003 }}</ref> | |||
==Gross== | |||
*+/-[[Gastric snakeskin appearance|Snakeskin appearance]]. | |||
DDx: | |||
*[[Portal hypertensive gastropathy]]. | |||
==Microscopic== | |||
Features: | |||
*Abundant [[eosinophil]]s -- >=127 eosinophils/mm<sup>2</sup>.<ref name=pmid21169993/> | |||
**30 eosinophils/[[HPF]], if the field diameter of 1 HPF is 0.55 mm. | |||
Notes: | |||
*Normal range:<ref name=pmid21169993>{{Cite journal | last1 = Lwin | first1 = T. | last2 = Melton | first2 = SD. | last3 = Genta | first3 = RM. | title = Eosinophilic gastritis: histopathological characterization and quantification of the normal gastric eosinophil content. | journal = Mod Pathol | volume = 24 | issue = 4 | pages = 556-63 | month = Apr | year = 2011 | doi = 10.1038/modpathol.2010.221 | PMID = 21169993 }}</ref> | |||
**<38 eosinophils/mm<sup>2</sup>. | |||
***Typically ~16 eosinophils/mm<sup>2</sup>. | |||
*Mild eosinophilia is seen in:<ref name=pmid21169993/> | |||
**[[Crohn's disease]] ~ 31 eosinophils/mm<sup>2</sup> (range: 0-203 eosinophils/mm<sup>2</sup>). | |||
**[[Helicobacter gastritis]] ~ 25 eosinophils/mm<sup>2</sup> (range: 0-219 eosinophils/mm<sup>2</sup>). | |||
DDx: | |||
*[[Chronic gastritis]]. | |||
*[[Helicobacter gastritis]]. | |||
*[[Crohn's disease]] - see ''[[inflammatory bowel disease and the stomach]]''. | |||
*Eosinophilic myeloproliferative neoplasm. | |||
*Eosinophilic gastroenteritis. | |||
*[[Inflammatory fibroid polyp]] - spindle cells. | |||
==Sign out== | |||
===Focal eosinophilia=== | |||
<pre> | |||
STOMACH, BIOPSY: | |||
- BODY AND ANTRAL-TYPE GASTRIC MUCOSA WITH MODERATE CHRONIC ACTIVE INFLAMMATION AND | |||
FOCAL EOSINOPHILIA. | |||
- NEGATIVE FOR HELICOBACTOR-LIKE ORGANISMS. | |||
- NEGATIVE FOR INTESTINAL METAPLASIA. | |||
- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY. | |||
COMMENT: | |||
One of four tissue fragments has eosinophilia, with 45 eosinophils/1 HPF (where 1 HPF | |||
is 0.2376 mm*mm). | |||
</pre> | |||
==See also== | |||
*[[Stomach]]. | |||
*[[Eosinophil]]. | |||
*[[Eosinophilic colitis]]. | |||
*[[Eosinophilic esophagitis]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Stomach]] | |||