Difference between revisions of "Eosinophilic, solid and cystic renal cell carcinoma"

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Eosinophilic, solid and cystic renal cell carcinoma (view source)

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| IHC        = [[PAX8]] +ve, [[CK20]] +ve, [[CK7]] -ve, CA9 -ve, CD117 -ve, HMB-45 -ve
| IHC        = [[PAX8]] +ve, [[CK20]] +ve, [[CK7]] -ve, CA9 -ve, CD117 -ve, HMB-45 -ve
| EM        =
| EM        =
| Molecular  =
| Molecular  = [[Renal neoplasms with TSC/mTOR pathway mutations|TSC/mTOR pathway mutations]]
| IF        =
| IF        =
| Gross      = solid and cystic
| Gross      = solid and cystic
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'''Eosinophilic, solid and cystic renal cell carcinoma''', abbreviated '''ESC-RCC''', is recently described, evolving [[kidney tumour]] that is presumed to be [[malignant]].<ref name=pmid26414221>{{Cite journal  | last1 = Trpkov | first1 = K. | last2 = Hes | first2 = O. | last3 = Bonert | first3 = M. | last4 = Lopez | first4 = JI. | last5 = Bonsib | first5 = SM. | last6 = Nesi | first6 = G. | last7 = Comperat | first7 = E. | last8 = Sibony | first8 = M. | last9 = Berney | first9 = DM. | title = Eosinophilic, Solid, and Cystic Renal Cell Carcinoma: Clinicopathologic Study of 16 Unique, Sporadic Neoplasms Occurring in Women. | journal = Am J Surg Pathol | volume =  | issue =  | pages =  | month = Sep | year = 2015 | doi = 10.1097/PAS.0000000000000508 | PMID = 26414221 }}</ref>
'''Eosinophilic, solid and cystic renal cell carcinoma''', abbreviated '''ESC-RCC''', is recently described, evolving [[kidney tumour]] that is presumed to be [[malignant]].<ref name=pmid26414221>{{Cite journal  | last1 = Trpkov | first1 = K. | last2 = Hes | first2 = O. | last3 = Bonert | first3 = M. | last4 = Lopez | first4 = JI. | last5 = Bonsib | first5 = SM. | last6 = Nesi | first6 = G. | last7 = Comperat | first7 = E. | last8 = Sibony | first8 = M. | last9 = Berney | first9 = DM. | title = Eosinophilic, Solid, and Cystic Renal Cell Carcinoma: Clinicopathologic Study of 16 Unique, Sporadic Neoplasms Occurring in Women. | journal = Am J Surg Pathol | volume =  | issue =  | pages =  | month = Sep | year = 2015 | doi = 10.1097/PAS.0000000000000508 | PMID = 26414221 }}</ref>


It is ''not'' within the [[Vancouver classification]] of [[renal tumours]].<ref name=pmid24025519>{{Cite journal  | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | last3 = Eble | first3 = JN. | last4 = Egevad | first4 = L. | last5 = Epstein | first5 = JI. | last6 = Grignon | first6 = D. | last7 = Hes | first7 = O. | last8 = Moch | first8 = H. | last9 = Montironi | first9 = R. | title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. | journal = Am J Surg Pathol | volume = 37 | issue = 10 | pages = 1469-89 | month = Oct | year = 2013 | doi = 10.1097/PAS.0b013e318299f2d1 | PMID = 24025519 }}</ref>
It is ''not'' within the WHO 2016 classification of [[renal tumours|renal neoplasia]].


==General==
==General==
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Image: Eosinophilic, solid and cystic renal cell carcinoma - 2 alt -- very high mag.jpg | ESC-RCC - very high mag.
Image: Eosinophilic, solid and cystic renal cell carcinoma - 2 alt -- very high mag.jpg | ESC-RCC - very high mag.
</gallery>
</gallery>
[[w:micrograph|Micrograph]] of '''eosinophilic, solid and cystic renal cell carcinoma''', abbreviated '''ESC-RCC'''. [[w:H&E stain|H&E stain]].
ESC-RCC is an evolving type of [[w:renal cell carcinoma|renal cell carcinoma]] that has a morphology similar to one seen in [[w:tuberous sclerosis|tuberous sclerosis]]-associated renal cell carcinoma.


====Case 3====
====Case 3====
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</gallery>
</gallery>


[[Category:Genitourinary pathology]]
====Case 4====
<gallery>
Image: Eosinophilic, solid and cystic renal cell carcinoma - 4 ~ intermed mag.jpg | ESC-RCC - intermed. mag.
Image: Eosinophilic, solid and cystic renal cell carcinoma - 4 ~ high mag.jpg | ESC-RCC - high mag.
Image: Eosinophilic, solid and cystic renal cell carcinoma - 4 ~ very high mag.jpg | ESC-RCC - very high mag.
</gallery>


==IHC==
==IHC==
Features:<ref name=pmid26414221/>
Features:<ref name=pmid26414221/>
*[[PAX8]] +ve.
*[[PAX8]] +ve.
*[[CK20]] +ve.
*[[CK20]] +ve (14/19 cases).<ref name=pmid28786877 >{{Cite journal  | last1 = Trpkov | first1 = K. | last2 = Abou-Ouf | first2 = H. | last3 = Hes | first3 = O. | last4 = Lopez | first4 = JI. | last5 = Nesi | first5 = G. | last6 = Comperat | first6 = E. | last7 = Sibony | first7 = M. | last8 = Osunkoya | first8 = AO. | last9 = Zhou | first9 = M. | title = Eosinophilic Solid and Cystic Renal Cell Carcinoma (ESC RCC): Further Morphologic and Molecular Characterization of ESC RCC as a Distinct Entity. | journal = Am J Surg Pathol | volume = 41 | issue = 10 | pages = 1299-1308 | month = Oct | year = 2017 | doi = 10.1097/PAS.0000000000000838 | PMID = 28786877 }}</ref>
*[[CK7]] -ve.
*[[CK7]] -ve.
*CD117 -ve.
*CD117 -ve.
*CA9 -ve.
*CA9 -ve.
*HMB-45 -ve.
*HMB-45 -ve.
==Molecular==
*[[Renal neoplasms with TSC/mTOR pathway mutations|TSC/mTOR pathway mutations]].<ref name=pmid35203531>{{cite journal |authors=Pivovarcikova K, Alaghehbandan R, Vanecek T, Ohashi R, Pitra T, Hes O |title=TSC/mTOR Pathway Mutation Associated Eosinophilic/Oncocytic Renal Neoplasms: A Heterogeneous Group of Tumors with Distinct Morphology, Immunohistochemical Profile, and Similar Genetic Background |journal=Biomedicines |volume=10 |issue=2 |pages= |date=January 2022 |pmid=35203531 |pmc=8869370 |doi=10.3390/biomedicines10020322 |url=}}</ref>


==See also==
==See also==
Michael
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