Difference between revisions of "Eosinophilic, solid and cystic renal cell carcinoma"

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| IHC        = [[PAX8]] +ve, [[CK20]] +ve, [[CK7]] -ve, CA9 -ve, CD117 -ve, HMB-45 -ve
| IHC        = [[PAX8]] +ve, [[CK20]] +ve, [[CK7]] -ve, CA9 -ve, CD117 -ve, HMB-45 -ve
| EM        =
| EM        =
| Molecular  =
| Molecular  = [[Renal neoplasms with TSC/mTOR pathway mutations|TSC/mTOR pathway mutations]]
| IF        =
| IF        =
| Gross      = solid and cystic
| Gross      = solid and cystic
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'''Eosinophilic, solid and cystic renal cell carcinoma''', abbreviated '''ESC-RCC''', is recently described, evolving [[kidney tumour]] that is presumed to be [[malignant]].<ref name=pmid26414221>{{Cite journal  | last1 = Trpkov | first1 = K. | last2 = Hes | first2 = O. | last3 = Bonert | first3 = M. | last4 = Lopez | first4 = JI. | last5 = Bonsib | first5 = SM. | last6 = Nesi | first6 = G. | last7 = Comperat | first7 = E. | last8 = Sibony | first8 = M. | last9 = Berney | first9 = DM. | title = Eosinophilic, Solid, and Cystic Renal Cell Carcinoma: Clinicopathologic Study of 16 Unique, Sporadic Neoplasms Occurring in Women. | journal = Am J Surg Pathol | volume =  | issue =  | pages =  | month = Sep | year = 2015 | doi = 10.1097/PAS.0000000000000508 | PMID = 26414221 }}</ref>
'''Eosinophilic, solid and cystic renal cell carcinoma''', abbreviated '''ESC-RCC''', is recently described, evolving [[kidney tumour]] that is presumed to be [[malignant]].<ref name=pmid26414221>{{Cite journal  | last1 = Trpkov | first1 = K. | last2 = Hes | first2 = O. | last3 = Bonert | first3 = M. | last4 = Lopez | first4 = JI. | last5 = Bonsib | first5 = SM. | last6 = Nesi | first6 = G. | last7 = Comperat | first7 = E. | last8 = Sibony | first8 = M. | last9 = Berney | first9 = DM. | title = Eosinophilic, Solid, and Cystic Renal Cell Carcinoma: Clinicopathologic Study of 16 Unique, Sporadic Neoplasms Occurring in Women. | journal = Am J Surg Pathol | volume =  | issue =  | pages =  | month = Sep | year = 2015 | doi = 10.1097/PAS.0000000000000508 | PMID = 26414221 }}</ref>


It is ''not'' within the [[Vancouver classification]] of [[renal tumours]].<ref name=pmid24025519>{{Cite journal  | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | last3 = Eble | first3 = JN. | last4 = Egevad | first4 = L. | last5 = Epstein | first5 = JI. | last6 = Grignon | first6 = D. | last7 = Hes | first7 = O. | last8 = Moch | first8 = H. | last9 = Montironi | first9 = R. | title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. | journal = Am J Surg Pathol | volume = 37 | issue = 10 | pages = 1469-89 | month = Oct | year = 2013 | doi = 10.1097/PAS.0b013e318299f2d1 | PMID = 24025519 }}</ref>
It is ''not'' within the WHO 2016 classification of [[renal tumours|renal neoplasia]].


==General==
==General==
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Image: Eosinophilic, solid and cystic renal cell carcinoma - 2 alt -- very high mag.jpg | ESC-RCC - very high mag.
Image: Eosinophilic, solid and cystic renal cell carcinoma - 2 alt -- very high mag.jpg | ESC-RCC - very high mag.
</gallery>
</gallery>
[[w:micrograph|Micrograph]] of '''eosinophilic, solid and cystic renal cell carcinoma''', abbreviated '''ESC-RCC'''. [[w:H&E stain|H&E stain]].
ESC-RCC is an evolving type of [[w:renal cell carcinoma|renal cell carcinoma]] that has a morphology similar to one seen in [[w:tuberous sclerosis|tuberous sclerosis]]-associated renal cell carcinoma.


====Case 3====
====Case 3====
Line 99: Line 94:
</gallery>
</gallery>


[[Category:Genitourinary pathology]]
====Case 4====
<gallery>
Image: Eosinophilic, solid and cystic renal cell carcinoma - 4 ~ intermed mag.jpg | ESC-RCC - intermed. mag.
Image: Eosinophilic, solid and cystic renal cell carcinoma - 4 ~ high mag.jpg | ESC-RCC - high mag.
Image: Eosinophilic, solid and cystic renal cell carcinoma - 4 ~ very high mag.jpg | ESC-RCC - very high mag.
</gallery>


==IHC==
==IHC==
Features:<ref name=pmid26414221/>
Features:<ref name=pmid26414221/>
*[[PAX8]] +ve.
*[[PAX8]] +ve.
*[[CK20]] +ve.
*[[CK20]] +ve (14/19 cases).<ref name=pmid28786877 >{{Cite journal  | last1 = Trpkov | first1 = K. | last2 = Abou-Ouf | first2 = H. | last3 = Hes | first3 = O. | last4 = Lopez | first4 = JI. | last5 = Nesi | first5 = G. | last6 = Comperat | first6 = E. | last7 = Sibony | first7 = M. | last8 = Osunkoya | first8 = AO. | last9 = Zhou | first9 = M. | title = Eosinophilic Solid and Cystic Renal Cell Carcinoma (ESC RCC): Further Morphologic and Molecular Characterization of ESC RCC as a Distinct Entity. | journal = Am J Surg Pathol | volume = 41 | issue = 10 | pages = 1299-1308 | month = Oct | year = 2017 | doi = 10.1097/PAS.0000000000000838 | PMID = 28786877 }}</ref>
*[[CK7]] -ve.
*[[CK7]] -ve.
*CD117 -ve.
*CD117 -ve.
*CA9 -ve.
*CA9 -ve.
*HMB-45 -ve.
*HMB-45 -ve.
==Molecular==
*[[Renal neoplasms with TSC/mTOR pathway mutations|TSC/mTOR pathway mutations]].<ref name=pmid35203531>{{cite journal |authors=Pivovarcikova K, Alaghehbandan R, Vanecek T, Ohashi R, Pitra T, Hes O |title=TSC/mTOR Pathway Mutation Associated Eosinophilic/Oncocytic Renal Neoplasms: A Heterogeneous Group of Tumors with Distinct Morphology, Immunohistochemical Profile, and Similar Genetic Background |journal=Biomedicines |volume=10 |issue=2 |pages= |date=January 2022 |pmid=35203531 |pmc=8869370 |doi=10.3390/biomedicines10020322 |url=}}</ref>


==See also==
==See also==

Latest revision as of 03:16, 25 April 2024

Eosinophilic, solid and cystic renal cell carcinoma
Diagnosis in short

Eosinophilic, solid and cystic renal cell carcinoma. H&E stain.
LM epithelioid cells with abundant stippled eosinophilic cytoplasm +/- peripheral clearing, round nuclei with prominent nucleoli, nested or solid architecture +/- cystic spaces with hobnail lining cells, +/-scattered histiocytes (common), +/-multi-nucleation (common), +/-small intracytoplasmic globules
LM DDx chromophobe renal cell carcinoma (eosinophilic variant), clear cell renal cell carcinoma, t(6;11) renal cell carcinoma, other renal tumours with eosinophilic cytoplasm
IHC PAX8 +ve, CK20 +ve, CK7 -ve, CA9 -ve, CD117 -ve, HMB-45 -ve
Molecular TSC/mTOR pathway mutations
Gross solid and cystic
Site kidney - see kidney tumours
Clinical history women only
Prevalence rare
Prognosis good - data limited
Clin. DDx other kidney tumours

Eosinophilic, solid and cystic renal cell carcinoma, abbreviated ESC-RCC, is recently described, evolving kidney tumour that is presumed to be malignant.[1]

It is not within the WHO 2016 classification of renal neoplasia.

General

Gross

Features:[1]

  • Tan colour.
  • Solid and usually cystic.

Microscopic

Features:[1]

  • Epithelioid cells with abundant stippled eosinophilic cytoplasm +/- peripheral clearing.
  • Round nuclei with one prominent nucleolus.
  • Nested or solid architecture +/- cystic spaces with hobnail lining cells.
  • +/-Scattered histiocytes (common).
  • +/-Multi-nucleation (common).
  • +/-Small intracytoplasmic globules - usually seen but only present in a handful of cells.

DDx:

Images

Case 1

  • ESC-RCC - low mag.

  • ESC-RCC - intermed. mag.

  • ESC-RCC - high mag.

  • ESC-RCC - very high mag.

  • ESC-RCC - intermed. mag.

  • ESC-RCC - high mag.

  • ESC-RCC - very high mag.

  • ESC-RCC - intermed. mag.

  • ESC-RCC - high mag.

Case 2

  • ESC-RCC - low mag.

  • ESC-RCC - intermed. mag.

  • ESC-RCC - high mag.

  • ESC-RCC - very high mag.

  • ESC-RCC - high mag.

  • ESC-RCC - very high mag.

Case 3

  • ESC-RCC - low mag.

  • ESC-RCC - intermed. mag.

  • ESC-RCC - high mag.

  • ESC-RCC - very high mag.

Case 4

  • ESC-RCC - intermed. mag.

  • ESC-RCC - high mag.

  • ESC-RCC - very high mag.

IHC

Features:[1]

  • PAX8 +ve.
  • CK20 +ve (14/19 cases).[3]
  • CK7 -ve.
  • CD117 -ve.
  • CA9 -ve.
  • HMB-45 -ve.

Molecular

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 Trpkov, K.; Hes, O.; Bonert, M.; Lopez, JI.; Bonsib, SM.; Nesi, G.; Comperat, E.; Sibony, M. et al. (Sep 2015). "Eosinophilic, Solid, and Cystic Renal Cell Carcinoma: Clinicopathologic Study of 16 Unique, Sporadic Neoplasms Occurring in Women.". Am J Surg Pathol. doi:10.1097/PAS.0000000000000508. PMID 26414221.
  2. ↑ Guo, J.; Tretiakova, MS.; Troxell, ML.; Osunkoya, AO.; Fadare, O.; Sangoi, AR.; Shen, SS.; Lopez-Beltran, A. et al. (Nov 2014). "Tuberous Sclerosis-associated Renal Cell Carcinoma: A Clinicopathologic Study of 57 Separate Carcinomas in 18 Patients.". Am J Surg Pathol 38 (11): 1457-67. doi:10.1097/PAS.0000000000000248. PMID 25093518.
  3. ↑ Trpkov, K.; Abou-Ouf, H.; Hes, O.; Lopez, JI.; Nesi, G.; Comperat, E.; Sibony, M.; Osunkoya, AO. et al. (Oct 2017). "Eosinophilic Solid and Cystic Renal Cell Carcinoma (ESC RCC): Further Morphologic and Molecular Characterization of ESC RCC as a Distinct Entity.". Am J Surg Pathol 41 (10): 1299-1308. doi:10.1097/PAS.0000000000000838. PMID 28786877.
  4. ↑ Pivovarcikova K, Alaghehbandan R, Vanecek T, Ohashi R, Pitra T, Hes O (January 2022). "TSC/mTOR Pathway Mutation Associated Eosinophilic/Oncocytic Renal Neoplasms: A Heterogeneous Group of Tumors with Distinct Morphology, Immunohistochemical Profile, and Similar Genetic Background". Biomedicines 10 (2). doi:10.3390/biomedicines10020322. PMC 8869370. PMID 35203531. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869370/.
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