48,466
edits
m (vauthors) |
|||
(7 intermediate revisions by 2 users not shown) | |||
Line 6: | Line 6: | ||
| Synonyms = enteropathy-type T-cell lymphoma | | Synonyms = enteropathy-type T-cell lymphoma | ||
| Micro = large or medium-sized lymphoid cells in the mucosa and submucosa | | Micro = large or medium-sized lymphoid cells in the mucosa and submucosa | ||
| Subtypes = | | Subtypes = Historical: pleomorphic anaplastic (type I), monomorphic (type II) | ||
| LMDDx = other lymphomas | | LMDDx = other lymphomas | ||
| Stains = | | Stains = | ||
Line 35: | Line 35: | ||
==General== | ==General== | ||
*T cell lymphoma due to [[celiac sprue]]. | *T cell lymphoma classically due to [[celiac sprue]]. | ||
* | *Historically subdivided into type I and type II.<ref name=pmid21566094>{{cite journal |author=Delabie J, et al |title=Enteropathy-associated T-cell lymphoma: clinical and histological findings from the International Peripheral T-Cell Lymphoma Project|journal=Blood |volume=118|issue=148|pages= 148|year=2011|month=July}}</ref> | ||
**''Pleomorphic anaplastic'' (type I) associated with celiac sprue.<ref name=pmid17511112/> - this is now referred to as EATL since the 2017 revision of the WHO blue book 4th edition. | |||
**''Monomorphic'' (type II) not associated with celiac sprue - this is separate entity known as [[monomorphic epitheliotropic intestinal T-cell lymphoma]] (MEITL); it is no longer referred to as EATL as it is not associated with an enteropathy. | |||
*Poor prognosis.<ref name=pmid23313469>{{Cite journal | last1 = Malamut | first1 = G. | last2 = Chandesris | first2 = O. | last3 = Verkarre | first3 = V. | last4 = Meresse | first4 = B. | last5 = Callens | first5 = C. | last6 = Macintyre | first6 = E. | last7 = Bouhnik | first7 = Y. | last8 = Gornet | first8 = JM. | last9 = Allez | first9 = M. | title = Enteropathy associated T cell lymphoma in celiac disease: a large retrospective study. | journal = Dig Liver Dis | volume = 45 | issue = 5 | pages = 377-84 | month = May | year = 2013 | doi = 10.1016/j.dld.2012.12.001 | PMID = 23313469 }}</ref> | *Poor prognosis.<ref name=pmid23313469>{{Cite journal | last1 = Malamut | first1 = G. | last2 = Chandesris | first2 = O. | last3 = Verkarre | first3 = V. | last4 = Meresse | first4 = B. | last5 = Callens | first5 = C. | last6 = Macintyre | first6 = E. | last7 = Bouhnik | first7 = Y. | last8 = Gornet | first8 = JM. | last9 = Allez | first9 = M. | title = Enteropathy associated T cell lymphoma in celiac disease: a large retrospective study. | journal = Dig Liver Dis | volume = 45 | issue = 5 | pages = 377-84 | month = May | year = 2013 | doi = 10.1016/j.dld.2012.12.001 | PMID = 23313469 }}</ref> | ||
**Five-year survival as low as 20%.<ref name=pmid24876396>{{Cite journal | last1 = Pun | first1 = AH. | last2 = Kasmeridis | first2 = H. | last3 = Rieger | first3 = N. | last4 = Loganathan | first4 = A. | title = Enteropathy associated T-cell lymphoma presenting with multiple episodes of small bowel haemorrhage and perforation. | journal = J Surg Case Rep | volume = 2014 | issue = 3 | pages = | month = | year = 2014 | doi = 10.1093/jscr/rju013 | PMID = 24876396 }}</ref> | **Five-year survival as low as 20%.<ref name=pmid24876396>{{Cite journal | last1 = Pun | first1 = AH. | last2 = Kasmeridis | first2 = H. | last3 = Rieger | first3 = N. | last4 = Loganathan | first4 = A. | title = Enteropathy associated T-cell lymphoma presenting with multiple episodes of small bowel haemorrhage and perforation. | journal = J Surg Case Rep | volume = 2014 | issue = 3 | pages = | month = | year = 2014 | doi = 10.1093/jscr/rju013 | PMID = 24876396 }}</ref> | ||
Line 73: | Line 75: | ||
==IHC== | ==IHC== | ||
Features - type 1:<ref name=pmid21323966/> | Features - type 1:<ref name=pmid21323966/><ref name=pmid17511112>{{cite journal |authors=Zettl A, deLeeuw R, Haralambieva E, Mueller-Hermelink HK |title=Enteropathy-type T-cell lymphoma |journal=Am. J. Clin. Pathol. |volume=127 |issue=5 |pages=701–6 |date=May 2007 |pmid=17511112 |doi=10.1309/nw2bk1dxb0eqg55h |url=}}</ref> | ||
*[[CD56]] | *[[CD56]] -ve. | ||
Features - type 2:<ref name=pmid21323966/><ref name=pmid21921780>{{Cite journal | last1 = Chan | first1 = JK. | last2 = Chan | first2 = AC. | last3 = Cheuk | first3 = W. | last4 = Wan | first4 = SK. | last5 = Lee | first5 = WK. | last6 = Lui | first6 = YH. | last7 = Chan | first7 = WK. | title = Type II enteropathy-associated T-cell lymphoma: a distinct aggressive lymphoma with frequent γδ T-cell receptor expression. | journal = Am J Surg Pathol | volume = 35 | issue = 10 | pages = 1557-69 | month = Oct | year = 2011 | doi = 10.1097/PAS.0b013e318222dfcd | PMID = 21921780 }}</ref> | Features - type 2:<ref name=pmid21323966/><ref name=pmid21921780>{{Cite journal | last1 = Chan | first1 = JK. | last2 = Chan | first2 = AC. | last3 = Cheuk | first3 = W. | last4 = Wan | first4 = SK. | last5 = Lee | first5 = WK. | last6 = Lui | first6 = YH. | last7 = Chan | first7 = WK. | title = Type II enteropathy-associated T-cell lymphoma: a distinct aggressive lymphoma with frequent γδ T-cell receptor expression. | journal = Am J Surg Pathol | volume = 35 | issue = 10 | pages = 1557-69 | month = Oct | year = 2011 | doi = 10.1097/PAS.0b013e318222dfcd | PMID = 21921780 }}</ref> | ||
Line 80: | Line 82: | ||
*CD5 -ve. | *CD5 -ve. | ||
*CD8 -ve/+ve. | *CD8 -ve/+ve. | ||
*CD56 | *CD56 +ve. | ||
*CD30 +ve. | *CD30 +ve. | ||
edits