Endometrium with squamous morules

From Libre Pathology
Revision as of 19:44, 18 December 2013 by Michael (talk | contribs)
Jump to navigation Jump to search

Endometrium with squamous morules is important to recognize as squamous morules are strongly associated with malignancy.

Endometrium with squamous morules
Diagnosis in short

Squamous morule. H&E stain.

LM well-circumscribed ball of squamoid cells -- cells have a whorled arrangement, moderate eosinophilic cytoplasm and a bland nucleus
LM DDx endometrial hyperplasia, endometrial carcinoma - esp. endometrioid endometrial carcinoma, uterine leiomyoma
Gross +/-endometrial thickening
Site endometrium

Associated Dx endometrial hyperplasia, endometrial carcinoma - esp. endometrioid endometrial carcinoma
Prognosis benign in itself, strong assoc. with malignancy
Squamous morules redirects here.

General

  • Benign finding in itself.
  • Strong association with malignancy.[1]
    • Associated with glandular lesions, i.e. endometrial hyperplasia and adenocarcinoma, not neoplastic squamous lesions.[2]

Microscopic

Features:

  • Well-circumscribed ball of squamoid cells:
    • Cells have a whorled arrangement.
    • Moderate eosinophilic cytoplasm.
    • Bland nucleus.
      • Smooth nuclear membrane.
      • Pale nuclear staining.
      • Fine chromatin pattern.

DDx:

Images

See also

References

  1. Nicolae, A.; Preda, O.; Nogales, FF. (Feb 2011). "Endometrial metaplasias and reactive changes: a spectrum of altered differentiation.". J Clin Pathol 64 (2): 97-106. doi:10.1136/jcp.2010.085555. PMID 21126963.
  2. Lin, MC.; Lomo, L.; Baak, JP.; Eng, C.; Ince, TA.; Crum, CP.; Mutter, GL. (Feb 2009). "Squamous morules are functionally inert elements of premalignant endometrial neoplasia.". Mod Pathol 22 (2): 167-74. doi:10.1038/modpathol.2008.146. PMID 19180120.