Difference between revisions of "Endometrium with changes due to selective progesterone receptor modulators"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Endometrium_with_SPRM_changes_-_b_--_very_low_mag.jpg | |||
| Width = | |||
| Caption = [[Micrograph]] showing [[endometrium]] with changes due to a SPRM. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = glandular changes - extensive cystic dilatation, inactive appearing glandular epithelium or abortive subnuclear vacuolization, rare mitoses or apoptotic cells, abnormal stromal vessels (common) | |||
| Subtypes = | |||
| LMDDx = [[endometrial hyperplasia]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Staging = | |||
| Site = [[endometrium]] | |||
| Assdx = [[uterine leiomyoma]]s | |||
| Syndromes = | |||
| Clinicalhx = use of SPRM | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = (none) | |||
}} | |||
'''Endometrium with changes due to selective progesterone receptor modulator''' may mimic [[endometrial hyperplasia]]. | '''Endometrium with changes due to selective progesterone receptor modulator''' may mimic [[endometrial hyperplasia]]. | ||
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DDx: | DDx: | ||
*[[Simple endometrial hyperplasia]]. | *[[Simple endometrial hyperplasia]]. | ||
===Images=== | |||
<gallery> | |||
Image: Endometrium with SPRM changes - a -- extremely low mag.jpg | SPRM endometrium - extremely low mag. (WC) | |||
Image: Endometrium with SPRM changes - a -- very low mag.jpg | SPRM endometrium - very low mag. (WC) | |||
Image: Endometrium with SPRM changes - b -- very low mag.jpg | SPRM endometrium - very low mag. (WC) | |||
Image: Endometrium with SPRM changes - b -- low mag.jpg | SPRM endometrium - low mag. (WC) | |||
Image: Endometrium with SPRM changes - c -- very low mag.jpg | SPRM endometrium - very low mag. (WC) | |||
Image: Endometrium with SPRM changes - c -- low mag.jpg | SPRM endometrium - low mag. (WC) | |||
Image: Endometrium with SPRM changes - c1 -- intermed mag.jpg | SPRM endometrium - intermed. mag. (WC) | |||
Image: Endometrium with SPRM changes - c2 -- intermed mag.jpg | SPRM endometrium - intermed. mag. (WC) | |||
Image: Endometrium with SPRM changes - c -- high mag.jpg | SPRM endometrium - high mag. (WC) | |||
Image: Endometrium with SPRM changes - c1 -- very high mag.jpg | SPRM endometrium - very high mag. (WC) | |||
Image: Endometrium with SPRM changes - c2 -- very high mag.jpg | SPRM endometrium - very high mag. (WC) | |||
</gallery> | |||
==See also== | ==See also== | ||
*[[Uterine fibroids]]. | *[[Uterine fibroids]]. | ||
*[[Tamoxifen]]. | |||
==References== | ==References== |
Latest revision as of 18:29, 30 August 2023
Endometrium with changes due to selective progesterone receptor modulators | |
---|---|
Diagnosis in short | |
Micrograph showing endometrium with changes due to a SPRM. H&E stain. | |
| |
LM | glandular changes - extensive cystic dilatation, inactive appearing glandular epithelium or abortive subnuclear vacuolization, rare mitoses or apoptotic cells, abnormal stromal vessels (common) |
LM DDx | endometrial hyperplasia |
Site | endometrium |
| |
Associated Dx | uterine leiomyomas |
Clinical history | use of SPRM |
Prognosis | benign |
Treatment | (none) |
Endometrium with changes due to selective progesterone receptor modulator may mimic endometrial hyperplasia.
Selective progesterone receptor modulators, abbreviated SPRMs, are a class of drugs that block the action of progesterone. They are used to treat uterine fibroids.[1]
General
- Ulipristal - trade name Fibristal.
- May be used as an emergency contraceptive.[2]
Microscopic
Features:[1]
- Glandular changes - extensive cystic dilatation.
- Inactive appearing glandular epithelium or abortive subnuclear vacuolization.
- Rare mitoses and apoptosis.
- Abnormal stromal vessels - common.
DDx:
Images
See also
References
- ↑ 1.0 1.1 Williams, AR.; Bergeron, C.; Barlow, DH.; Ferenczy, A. (Nov 2012). "Endometrial morphology after treatment of uterine fibroids with the selective progesterone receptor modulator, ulipristal acetate.". Int J Gynecol Pathol 31 (6): 556-69. doi:10.1097/PGP.0b013e318251035b. PMID 23018219.
- ↑ Whitaker, LH.; Williams, AR.; Critchley, HO. (Aug 2014). "Selective progesterone receptor modulators.". Curr Opin Obstet Gynecol 26 (4): 237-42. doi:10.1097/GCO.0000000000000082. PMID 24950125.