Difference between revisions of "Endometrium with changes due to selective progesterone receptor modulators"

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'''Selective progesterone receptor modulators''', abbreviated '''SPRMs''', are a class of drugs that block the action of progesterone.  They are used to treat [[uterine fibroids]].<ref name=pmid23018219>{{Cite journal  | last1 = Williams | first1 = AR. | last2 = Bergeron | first2 = C. | last3 = Barlow | first3 = DH. | last4 = Ferenczy | first4 = A. | title = Endometrial morphology after treatment of uterine fibroids with the selective progesterone receptor modulator, ulipristal acetate. | journal = Int J Gynecol Pathol | volume = 31 | issue = 6 | pages = 556-69 | month = Nov | year = 2012 | doi = 10.1097/PGP.0b013e318251035b | PMID = 23018219 }}</ref>
'''Selective progesterone receptor modulators''', abbreviated '''SPRMs''', are a class of drugs that block the action of progesterone.  They are used to treat [[uterine fibroids]].<ref name=pmid23018219>{{Cite journal  | last1 = Williams | first1 = AR. | last2 = Bergeron | first2 = C. | last3 = Barlow | first3 = DH. | last4 = Ferenczy | first4 = A. | title = Endometrial morphology after treatment of uterine fibroids with the selective progesterone receptor modulator, ulipristal acetate. | journal = Int J Gynecol Pathol | volume = 31 | issue = 6 | pages = 556-69 | month = Nov | year = 2012 | doi = 10.1097/PGP.0b013e318251035b | PMID = 23018219 }}</ref>
==Microscopic==
Features:<ref name=pmid23018219/>
*Glandular changes - extensive cystic dilatation.
*Inactive appearing glandular epithelium or abortive subnuclear vacuolization.
*Rare mitoses and apoptosis.
*Abnormal stromal vessels - common.
DDx:
*[[Simple endometrial hyperplasia]].


==See also==
==See also==

Revision as of 18:38, 3 January 2017

Selective progesterone receptor modulators, abbreviated SPRMs, are a class of drugs that block the action of progesterone. They are used to treat uterine fibroids.[1]

Microscopic

Features:[1]

  • Glandular changes - extensive cystic dilatation.
  • Inactive appearing glandular epithelium or abortive subnuclear vacuolization.
  • Rare mitoses and apoptosis.
  • Abnormal stromal vessels - common.

DDx:

See also

References

  1. ↑ 1.0 1.1 Williams, AR.; Bergeron, C.; Barlow, DH.; Ferenczy, A. (Nov 2012). "Endometrial morphology after treatment of uterine fibroids with the selective progesterone receptor modulator, ulipristal acetate.". Int J Gynecol Pathol 31 (6): 556-69. doi:10.1097/PGP.0b013e318251035b. PMID 23018219.
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