Difference between revisions of "Endometrial stromal sarcoma"
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| Caption = Endometrial stromal sarcoma. [[H&E stain]]. | | Caption = Endometrial stromal sarcoma. [[H&E stain]]. | ||
| Micro = | | Micro = highly cellular islands of (tumour) cells with a wavy irregular border -- benign uterine smooth muscle between; tumour cells: high [[NC ratio]] and epithelioid, pallisade around thin blood vessels within the tumour | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = [[leiomyoma]] (cellular), [[endometrial stromal nodule]], [[Uterine leiomyosarcoma]]. | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = CD10 +ve, H-caldesmin -ve, PR +/-ve, ER +/-ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = t(7;17) | ||
| IF = | | IF = | ||
| Gross = | | Gross = | ||
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==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*Highly cellular | *Highly cellular islands with a wavy irregular border. | ||
**Border has finger-like projections/[[tongue]]-like projections. | **Border has finger-like projections/[[tongue]]-like projections. | ||
**Benign uterine smooth muscle between islands of tumour cells. | **Benign uterine smooth muscle between islands of tumour cells. | ||
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Features:<ref name=pmid14751141>{{Cite journal | last1 = Zhu | first1 = XQ. | last2 = Shi | first2 = YF. | last3 = Cheng | first3 = XD. | last4 = Zhao | first4 = CL. | last5 = Wu | first5 = YZ. | title = Immunohistochemical markers in differential diagnosis of endometrial stromal sarcoma and cellular leiomyoma. | journal = Gynecol Oncol | volume = 92 | issue = 1 | pages = 71-9 | month = Jan | year = 2004 | doi = | PMID = 14751141 }}</ref> | Features:<ref name=pmid14751141>{{Cite journal | last1 = Zhu | first1 = XQ. | last2 = Shi | first2 = YF. | last3 = Cheng | first3 = XD. | last4 = Zhao | first4 = CL. | last5 = Wu | first5 = YZ. | title = Immunohistochemical markers in differential diagnosis of endometrial stromal sarcoma and cellular leiomyoma. | journal = Gynecol Oncol | volume = 92 | issue = 1 | pages = 71-9 | month = Jan | year = 2004 | doi = | PMID = 14751141 }}</ref> | ||
*CD10 +ve. | *CD10 +ve. | ||
* | *H-caldesmin -ve. | ||
**[[Leiomyoma]]s +ve. | **[[Leiomyoma]]s +ve. | ||
*PR +/-ve. | *PR +/-ve. | ||