End-stage kidney

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General

  • Many end-stage renal disease (ESRD) kidneys have a similar appearance.
    • Notable exception: polycystic kidney diseases have distinctive appearance, e.g. ADPKD.

Gross

  • Small kidneys.
  • Thinned renal cortex.
  • +/-Dilated renal calyces.
  • +/-Cysts.

Note:

  • Normal (adult) kidneys are ~11 cm from pole-to-pole.[1]

Microscopic

Features:

  • Global sclerosis of the glomeruli.
  • Interstitial fibrosis.
  • +/-Thyroidization - colloid-like hyaline cast formation that impart an appearance that mimics the thyroid gland:[2]

Image:

See also

References

  1. Glodny, B.; Unterholzner, V.; Taferner, B.; Hofmann, KJ.; Rehder, P.; Strasak, A.; Petersen, J. (2009). "Normal kidney size and its influencing factors - a 64-slice MDCT study of 1.040 asymptomatic patients.". BMC Urol 9: 19. doi:10.1186/1471-2490-9-19. PMID 20030823.
  2. Ito, S.; Kobayashi, A.; Tsuchiya, T.; Moriyama, Y.; Kikuchi, M.; Deguchi, T.; Yamaguchi, Y. (Aug 2009). "Thyroidization in renal allografts.". Clin Transplant 23 Suppl 20: 6-9. doi:10.1111/j.1399-0012.2009.01001.x. PMID 19594588.